Exploring the role of stromal osmoregulation in cancer and disease using executable modelling

Aberrant ion transporter expression disrupts osmoregulation in many cancers. Here, the authors introduce an executable model of osmotic regulation and membrane transport, illuminating the mechanistic basis of multiple cellular cancer phenotypes and suggesting therapeutic avenues.

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Detalles Bibliográficos
Autores principales:	David Shorthouse, Angela Riedel, Emma Kerr, Luisa Pedro, Dóra Bihary, Shamith Samarajiwa, Carla P. Martins, Jacqueline Shields, Benjamin A. Hall
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/da32886ecfdc4f129d741fa8e63bc987
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spelling	oai:doaj.org-article:da32886ecfdc4f129d741fa8e63bc9872021-12-02T14:39:46ZExploring the role of stromal osmoregulation in cancer and disease using executable modelling10.1038/s41467-018-05414-y2041-1723https://doaj.org/article/da32886ecfdc4f129d741fa8e63bc9872018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05414-yhttps://doaj.org/toc/2041-1723Aberrant ion transporter expression disrupts osmoregulation in many cancers. Here, the authors introduce an executable model of osmotic regulation and membrane transport, illuminating the mechanistic basis of multiple cellular cancer phenotypes and suggesting therapeutic avenues.David ShorthouseAngela RiedelEmma KerrLuisa PedroDóra BiharyShamith SamarajiwaCarla P. MartinsJacqueline ShieldsBenjamin A. HallNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David Shorthouse Angela Riedel Emma Kerr Luisa Pedro Dóra Bihary Shamith Samarajiwa Carla P. Martins Jacqueline Shields Benjamin A. Hall Exploring the role of stromal osmoregulation in cancer and disease using executable modelling
description	Aberrant ion transporter expression disrupts osmoregulation in many cancers. Here, the authors introduce an executable model of osmotic regulation and membrane transport, illuminating the mechanistic basis of multiple cellular cancer phenotypes and suggesting therapeutic avenues.
format	article
author	David Shorthouse Angela Riedel Emma Kerr Luisa Pedro Dóra Bihary Shamith Samarajiwa Carla P. Martins Jacqueline Shields Benjamin A. Hall
author_facet	David Shorthouse Angela Riedel Emma Kerr Luisa Pedro Dóra Bihary Shamith Samarajiwa Carla P. Martins Jacqueline Shields Benjamin A. Hall
author_sort	David Shorthouse
title	Exploring the role of stromal osmoregulation in cancer and disease using executable modelling
title_short	Exploring the role of stromal osmoregulation in cancer and disease using executable modelling
title_full	Exploring the role of stromal osmoregulation in cancer and disease using executable modelling
title_fullStr	Exploring the role of stromal osmoregulation in cancer and disease using executable modelling
title_full_unstemmed	Exploring the role of stromal osmoregulation in cancer and disease using executable modelling
title_sort	exploring the role of stromal osmoregulation in cancer and disease using executable modelling
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/da32886ecfdc4f129d741fa8e63bc987
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Exploring the role of stromal osmoregulation in cancer and disease using executable modelling

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