Effects of Calcitonin-Gene-Related-Peptide on Auditory Nerve Activity

Calcitonin-gene-related peptide (CGRP) is a lateral olivocochlear (LOC) efferent neurotransmitter. Depression of sound-driven auditory brainstem response amplitude in CGRP-null mice suggests the potential for endogenous CGRP release to upregulate spontaneous and/or sound-driven auditory nerve (AN) a...

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Autores principales:	Colleen G. Le Prell, Larry F. Hughes, David F. Dolan, Sanford C. Bledsoe
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cochlea CGRP auditory nerve auditory brainstem response lateral olivocochlear efferent Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/da331045411241ee9f706217ac1aa598
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spelling	oai:doaj.org-article:da331045411241ee9f706217ac1aa5982021-11-12T06:11:10ZEffects of Calcitonin-Gene-Related-Peptide on Auditory Nerve Activity2296-634X10.3389/fcell.2021.752963https://doaj.org/article/da331045411241ee9f706217ac1aa5982021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.752963/fullhttps://doaj.org/toc/2296-634XCalcitonin-gene-related peptide (CGRP) is a lateral olivocochlear (LOC) efferent neurotransmitter. Depression of sound-driven auditory brainstem response amplitude in CGRP-null mice suggests the potential for endogenous CGRP release to upregulate spontaneous and/or sound-driven auditory nerve (AN) activity. We chronically infused CGRP into the guinea pig cochlea and evaluated changes in AN activity as well as outer hair cell (OHC) function. The amplitude of both round window noise (a measure of ensemble spontaneous activity) and the synchronous whole-nerve response to sound (compound action potential, CAP) were enhanced. Lack of change in both onset adaptation and steady state amplitude of sound-evoked distortion product otoacoustic emission (DPOAE) responses indicated CGRP had no effect on OHCs, suggesting the origin of the observed changes was neural. Combined with results from the CGRP-null mice, these results appear to confirm that endogenous CGRP enhances auditory nerve activity when released by the LOC neurons. However, infusion of the CGRP receptor antagonist CGRP (8–37) did not reliably influence spontaneous or sound-driven AN activity, or OHC function, results that contrast with the decreased ABR amplitude measured in CGRP-null mice.Colleen G. Le PrellColleen G. Le PrellLarry F. HughesDavid F. DolanSanford C. BledsoeFrontiers Media S.A.articlecochleaCGRPauditory nerveauditory brainstem responselateral olivocochlear efferentBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cochlea CGRP auditory nerve auditory brainstem response lateral olivocochlear efferent Biology (General) QH301-705.5
spellingShingle	cochlea CGRP auditory nerve auditory brainstem response lateral olivocochlear efferent Biology (General) QH301-705.5 Colleen G. Le Prell Colleen G. Le Prell Larry F. Hughes David F. Dolan Sanford C. Bledsoe Effects of Calcitonin-Gene-Related-Peptide on Auditory Nerve Activity
description	Calcitonin-gene-related peptide (CGRP) is a lateral olivocochlear (LOC) efferent neurotransmitter. Depression of sound-driven auditory brainstem response amplitude in CGRP-null mice suggests the potential for endogenous CGRP release to upregulate spontaneous and/or sound-driven auditory nerve (AN) activity. We chronically infused CGRP into the guinea pig cochlea and evaluated changes in AN activity as well as outer hair cell (OHC) function. The amplitude of both round window noise (a measure of ensemble spontaneous activity) and the synchronous whole-nerve response to sound (compound action potential, CAP) were enhanced. Lack of change in both onset adaptation and steady state amplitude of sound-evoked distortion product otoacoustic emission (DPOAE) responses indicated CGRP had no effect on OHCs, suggesting the origin of the observed changes was neural. Combined with results from the CGRP-null mice, these results appear to confirm that endogenous CGRP enhances auditory nerve activity when released by the LOC neurons. However, infusion of the CGRP receptor antagonist CGRP (8–37) did not reliably influence spontaneous or sound-driven AN activity, or OHC function, results that contrast with the decreased ABR amplitude measured in CGRP-null mice.
format	article
author	Colleen G. Le Prell Colleen G. Le Prell Larry F. Hughes David F. Dolan Sanford C. Bledsoe
author_facet	Colleen G. Le Prell Colleen G. Le Prell Larry F. Hughes David F. Dolan Sanford C. Bledsoe
author_sort	Colleen G. Le Prell
title	Effects of Calcitonin-Gene-Related-Peptide on Auditory Nerve Activity
title_short	Effects of Calcitonin-Gene-Related-Peptide on Auditory Nerve Activity
title_full	Effects of Calcitonin-Gene-Related-Peptide on Auditory Nerve Activity
title_fullStr	Effects of Calcitonin-Gene-Related-Peptide on Auditory Nerve Activity
title_full_unstemmed	Effects of Calcitonin-Gene-Related-Peptide on Auditory Nerve Activity
title_sort	effects of calcitonin-gene-related-peptide on auditory nerve activity
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/da331045411241ee9f706217ac1aa598
work_keys_str_mv	AT colleengleprell effectsofcalcitoningenerelatedpeptideonauditorynerveactivity AT colleengleprell effectsofcalcitoningenerelatedpeptideonauditorynerveactivity AT larryfhughes effectsofcalcitoningenerelatedpeptideonauditorynerveactivity AT davidfdolan effectsofcalcitoningenerelatedpeptideonauditorynerveactivity AT sanfordcbledsoe effectsofcalcitoningenerelatedpeptideonauditorynerveactivity
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Effects of Calcitonin-Gene-Related-Peptide on Auditory Nerve Activity

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