Modulating testosterone pathway: a new strategy to tackle male skin aging?

Philippe Bernard1, Thomas Scior2, Quoc Tuan Do11Greenpharma SAS, Orléans, France; 2Pharmacy Department, Benemerita Universidad Autonoma de Puebla, Puebla, MexicoAbstract: In men, the level of testosterone decreases with age. At the skin level, the result is observed as a decrease in densi...

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Autores principales:	Bernard P, Scior T, Do QT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Reverse pharmacognosy honokiol testosterone man cosmetics dermopharmacy Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/da3a326c3bdc4ab08f6c204895b24e3a
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spelling	oai:doaj.org-article:da3a326c3bdc4ab08f6c204895b24e3a2021-12-02T01:47:33ZModulating testosterone pathway: a new strategy to tackle male skin aging?1178-1998https://doaj.org/article/da3a326c3bdc4ab08f6c204895b24e3a2012-09-01T00:00:00Zhttps://www.dovepress.com/modulating-testosterone-pathway-a-new-strategy-to-tackle-male-skin-agi-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Philippe Bernard1, Thomas Scior2, Quoc Tuan Do11Greenpharma SAS, Orléans, France; 2Pharmacy Department, Benemerita Universidad Autonoma de Puebla, Puebla, MexicoAbstract: In men, the level of testosterone decreases with age. At the skin level, the result is observed as a decrease in density and in a lower elasticity. Identifying compounds that are able to increase the level of testosterone appears to be an attractive strategy to develop new antiaging bioactive ingredients for men. Reverse pharmacognosy was successfully applied to identify new natural compounds able to modulate testosterone levels. Among several in silico hits, honokiol was retained as a candidate as it has the greatest potential to become an active ingredient. This result was then validated in vitro on aromatase and 5-alpha-reductase type 1 and 2, which are two types of enzymes implicated in the degradation of free testosterone. Indeed, honokiol was identified as an inhibitor of aromatase, with a half-maximal inhibitory concentration (IC50) of about 50 µM. In addition, honokiol was shown to be an inhibitor of 5-alpha-reductase type 1, with an IC50 of about 75 µM. Taken together, these data indicate that honokiol modulates testosterone levels, and its structure has the potential to serve as a lead for future designs of highly selective inhibitors of 5-alpha-reductase type 1.Keywords: reverse pharmacognosy, honokiol, testosterone, man cosmetics, dermopharmacyBernard PScior TDo QTDove Medical PressarticleReverse pharmacognosyhonokioltestosteroneman cosmeticsdermopharmacyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 7, Pp 351-361 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Reverse pharmacognosy honokiol testosterone man cosmetics dermopharmacy Geriatrics RC952-954.6
spellingShingle	Reverse pharmacognosy honokiol testosterone man cosmetics dermopharmacy Geriatrics RC952-954.6 Bernard P Scior T Do QT Modulating testosterone pathway: a new strategy to tackle male skin aging?
description	Philippe Bernard1, Thomas Scior2, Quoc Tuan Do11Greenpharma SAS, Orléans, France; 2Pharmacy Department, Benemerita Universidad Autonoma de Puebla, Puebla, MexicoAbstract: In men, the level of testosterone decreases with age. At the skin level, the result is observed as a decrease in density and in a lower elasticity. Identifying compounds that are able to increase the level of testosterone appears to be an attractive strategy to develop new antiaging bioactive ingredients for men. Reverse pharmacognosy was successfully applied to identify new natural compounds able to modulate testosterone levels. Among several in silico hits, honokiol was retained as a candidate as it has the greatest potential to become an active ingredient. This result was then validated in vitro on aromatase and 5-alpha-reductase type 1 and 2, which are two types of enzymes implicated in the degradation of free testosterone. Indeed, honokiol was identified as an inhibitor of aromatase, with a half-maximal inhibitory concentration (IC50) of about 50 µM. In addition, honokiol was shown to be an inhibitor of 5-alpha-reductase type 1, with an IC50 of about 75 µM. Taken together, these data indicate that honokiol modulates testosterone levels, and its structure has the potential to serve as a lead for future designs of highly selective inhibitors of 5-alpha-reductase type 1.Keywords: reverse pharmacognosy, honokiol, testosterone, man cosmetics, dermopharmacy
format	article
author	Bernard P Scior T Do QT
author_facet	Bernard P Scior T Do QT
author_sort	Bernard P
title	Modulating testosterone pathway: a new strategy to tackle male skin aging?
title_short	Modulating testosterone pathway: a new strategy to tackle male skin aging?
title_full	Modulating testosterone pathway: a new strategy to tackle male skin aging?
title_fullStr	Modulating testosterone pathway: a new strategy to tackle male skin aging?
title_full_unstemmed	Modulating testosterone pathway: a new strategy to tackle male skin aging?
title_sort	modulating testosterone pathway: a new strategy to tackle male skin aging?
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/da3a326c3bdc4ab08f6c204895b24e3a
work_keys_str_mv	AT bernardp modulatingtestosteronepathwayanewstrategytotacklemaleskinaging AT sciort modulatingtestosteronepathwayanewstrategytotacklemaleskinaging AT doqt modulatingtestosteronepathwayanewstrategytotacklemaleskinaging
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Modulating testosterone pathway: a new strategy to tackle male skin aging?

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