Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation

Abstract Background The incidence of kidney transplantation performed in elderly patients has increased steadily recently. Higher risk of infection and mortality, but lower rate of rejection, are reported in older kidney transplant patients. This study aims to analyze the effect of transplantation o...

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Autores principales:	Lei Wang, Christien Rondaan, Anoek A. E. de Joode, Elisabeth Raveling-Eelsing, Nicolaas A. Bos, Johanna Westra
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Kidney transplant Ageing CMV Senescent T cells Age associated B cells Immunologic diseases. Allergy RC581-607 Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/da3dff3333ef43ba80ca2b01f4a673d5
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spelling	oai:doaj.org-article:da3dff3333ef43ba80ca2b01f4a673d52021-11-14T12:10:05ZChanges in T and B cell subsets in end stage renal disease patients before and after kidney transplantation10.1186/s12979-021-00254-91742-4933https://doaj.org/article/da3dff3333ef43ba80ca2b01f4a673d52021-11-01T00:00:00Zhttps://doi.org/10.1186/s12979-021-00254-9https://doaj.org/toc/1742-4933Abstract Background The incidence of kidney transplantation performed in elderly patients has increased steadily recently. Higher risk of infection and mortality, but lower rate of rejection, are reported in older kidney transplant patients. This study aims to analyze the effect of transplantation on aging of T and B cells in kidney transplant patients, with the emphasis on age and Cytomegalovirus (CMV) latency. Results We included 36 patients before and after (median 2.7 years) kidney transplantation and 27 age- and sex-matched healthy controls (HC). T and B cell subsets were measured by flow cytometry, with a focus on aged T cells (CD28-), and age associated B cells (ABCs, CD19 + CD21-CD11c+). Three years after transplantation a significant increase of total T cells among the lymphocytes was found compared to pre-transplantation and HC. Among the T cells CD4+ cells were decreased, especially naïve CD4+ cells and regulatory T cells. Total CD8+ cell proportions were increased, and proportions of naïve CD8+ cells were significantly decreased after transplantation, while CD8+ effector memory T cells re-expressing CD45RA were increased. CD28− T cells were significantly higher compared to HC after transplantation, especially in CMV seropositive patients. B cells were significantly decreased, while among B cells memory B cells and especially ABCs were increased after transplantation. Conclusions After transplantation T and B cell subsets change towards more terminally differentiated memory cells compared to age-matched HC. Proportions of aged T cells and ABCs were associated with CMV serostatus.Lei WangChristien RondaanAnoek A. E. de JoodeElisabeth Raveling-EelsingNicolaas A. BosJohanna WestraBMCarticleKidney transplantAgeingCMVSenescent T cellsAge associated B cellsImmunologic diseases. AllergyRC581-607GeriatricsRC952-954.6ENImmunity & Ageing, Vol 18, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Kidney transplant Ageing CMV Senescent T cells Age associated B cells Immunologic diseases. Allergy RC581-607 Geriatrics RC952-954.6
spellingShingle	Kidney transplant Ageing CMV Senescent T cells Age associated B cells Immunologic diseases. Allergy RC581-607 Geriatrics RC952-954.6 Lei Wang Christien Rondaan Anoek A. E. de Joode Elisabeth Raveling-Eelsing Nicolaas A. Bos Johanna Westra Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation
description	Abstract Background The incidence of kidney transplantation performed in elderly patients has increased steadily recently. Higher risk of infection and mortality, but lower rate of rejection, are reported in older kidney transplant patients. This study aims to analyze the effect of transplantation on aging of T and B cells in kidney transplant patients, with the emphasis on age and Cytomegalovirus (CMV) latency. Results We included 36 patients before and after (median 2.7 years) kidney transplantation and 27 age- and sex-matched healthy controls (HC). T and B cell subsets were measured by flow cytometry, with a focus on aged T cells (CD28-), and age associated B cells (ABCs, CD19 + CD21-CD11c+). Three years after transplantation a significant increase of total T cells among the lymphocytes was found compared to pre-transplantation and HC. Among the T cells CD4+ cells were decreased, especially naïve CD4+ cells and regulatory T cells. Total CD8+ cell proportions were increased, and proportions of naïve CD8+ cells were significantly decreased after transplantation, while CD8+ effector memory T cells re-expressing CD45RA were increased. CD28− T cells were significantly higher compared to HC after transplantation, especially in CMV seropositive patients. B cells were significantly decreased, while among B cells memory B cells and especially ABCs were increased after transplantation. Conclusions After transplantation T and B cell subsets change towards more terminally differentiated memory cells compared to age-matched HC. Proportions of aged T cells and ABCs were associated with CMV serostatus.
format	article
author	Lei Wang Christien Rondaan Anoek A. E. de Joode Elisabeth Raveling-Eelsing Nicolaas A. Bos Johanna Westra
author_facet	Lei Wang Christien Rondaan Anoek A. E. de Joode Elisabeth Raveling-Eelsing Nicolaas A. Bos Johanna Westra
author_sort	Lei Wang
title	Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation
title_short	Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation
title_full	Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation
title_fullStr	Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation
title_full_unstemmed	Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation
title_sort	changes in t and b cell subsets in end stage renal disease patients before and after kidney transplantation
publisher	BMC
publishDate	2021
url	https://doaj.org/article/da3dff3333ef43ba80ca2b01f4a673d5
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Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation

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