APOE ɛ4 Is Associated with Postprandial Inflammation in Older Adults with Metabolic Syndrome Traits

The apolipoprotein E (<i>APOE</i>) polymorphism impacts blood lipids and biomarkers of oxidation and inflammation, contributing to an isoform-dependent disease risk. We investigated the effect of the <i>APOE</i> genotype on postprandial metabolism after consumption of three d...

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Autores principales:	Yannik Bernd Schönknecht, Silke Crommen, Birgit Stoffel-Wagner, Martin Coenen, Rolf Fimmers, Peter Stehle, Alfredo Ramirez, Sarah Egert
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	apolipoprotein E gene polymorphism dietary pattern inflammation oxidative stress postprandial state Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/da3e177c14074d6a8a943c18eb731598
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spelling	oai:doaj.org-article:da3e177c14074d6a8a943c18eb7315982021-11-25T18:35:21ZAPOE ɛ4 Is Associated with Postprandial Inflammation in Older Adults with Metabolic Syndrome Traits10.3390/nu131139242072-6643https://doaj.org/article/da3e177c14074d6a8a943c18eb7315982021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3924https://doaj.org/toc/2072-6643The apolipoprotein E (<i>APOE</i>) polymorphism impacts blood lipids and biomarkers of oxidation and inflammation, contributing to an isoform-dependent disease risk. We investigated the effect of the <i>APOE</i> genotype on postprandial metabolism after consumption of three different isoenergetic (4200 kJ) meals in older adults with a CVD risk phenotype. In a randomized crossover study, participants with metabolic syndrome traits (<i>APOE</i> E3, n = 39; E4, n = 10; mean age, 70 ± 5 years; BMI 31.3 ± 3.0 kg/m<sup>2</sup>) consumed a Western-like diet high-fat (WDHF), Western-like diet high-carbohydrate (WDHC), or Mediterranean-like diet (MED) meal. Parameters of lipid and glucose metabolism, inflammatory, and oxidative parameters were analyzed in blood samples collected at fasting and 1–5 h postprandially. Data were analyzed by linear mixed models. The magnitude of the IL-6 increase after the WDHF meal was significantly higher in E4 than in E3 carriers (iAUC: E4 = 7.76 vs. E3 = 2.81 pg/mL × h). The time to detect the IL-6 increase was shorter in the E4 group. All meals produced postprandial glycemia, insulinemia, and lipidemia, without differences between the E3 and the E4 groups. IL-1β and oxidized LDL levels did not change postprandially. In conclusion, APOE E4 carriers display increased postprandial inflammation, indicated by higher postprandial IL-6 increase, when compared to non-carriers.Yannik Bernd SchönknechtSilke CrommenBirgit Stoffel-WagnerMartin CoenenRolf FimmersPeter StehleAlfredo RamirezSarah EgertMDPI AGarticleapolipoprotein E gene polymorphismdietary patterninflammationoxidative stresspostprandial stateNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3924, p 3924 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	apolipoprotein E gene polymorphism dietary pattern inflammation oxidative stress postprandial state Nutrition. Foods and food supply TX341-641
spellingShingle	apolipoprotein E gene polymorphism dietary pattern inflammation oxidative stress postprandial state Nutrition. Foods and food supply TX341-641 Yannik Bernd Schönknecht Silke Crommen Birgit Stoffel-Wagner Martin Coenen Rolf Fimmers Peter Stehle Alfredo Ramirez Sarah Egert APOE ɛ4 Is Associated with Postprandial Inflammation in Older Adults with Metabolic Syndrome Traits
description	The apolipoprotein E (<i>APOE</i>) polymorphism impacts blood lipids and biomarkers of oxidation and inflammation, contributing to an isoform-dependent disease risk. We investigated the effect of the <i>APOE</i> genotype on postprandial metabolism after consumption of three different isoenergetic (4200 kJ) meals in older adults with a CVD risk phenotype. In a randomized crossover study, participants with metabolic syndrome traits (<i>APOE</i> E3, n = 39; E4, n = 10; mean age, 70 ± 5 years; BMI 31.3 ± 3.0 kg/m<sup>2</sup>) consumed a Western-like diet high-fat (WDHF), Western-like diet high-carbohydrate (WDHC), or Mediterranean-like diet (MED) meal. Parameters of lipid and glucose metabolism, inflammatory, and oxidative parameters were analyzed in blood samples collected at fasting and 1–5 h postprandially. Data were analyzed by linear mixed models. The magnitude of the IL-6 increase after the WDHF meal was significantly higher in E4 than in E3 carriers (iAUC: E4 = 7.76 vs. E3 = 2.81 pg/mL × h). The time to detect the IL-6 increase was shorter in the E4 group. All meals produced postprandial glycemia, insulinemia, and lipidemia, without differences between the E3 and the E4 groups. IL-1β and oxidized LDL levels did not change postprandially. In conclusion, APOE E4 carriers display increased postprandial inflammation, indicated by higher postprandial IL-6 increase, when compared to non-carriers.
format	article
author	Yannik Bernd Schönknecht Silke Crommen Birgit Stoffel-Wagner Martin Coenen Rolf Fimmers Peter Stehle Alfredo Ramirez Sarah Egert
author_facet	Yannik Bernd Schönknecht Silke Crommen Birgit Stoffel-Wagner Martin Coenen Rolf Fimmers Peter Stehle Alfredo Ramirez Sarah Egert
author_sort	Yannik Bernd Schönknecht
title	APOE ɛ4 Is Associated with Postprandial Inflammation in Older Adults with Metabolic Syndrome Traits
title_short	APOE ɛ4 Is Associated with Postprandial Inflammation in Older Adults with Metabolic Syndrome Traits
title_full	APOE ɛ4 Is Associated with Postprandial Inflammation in Older Adults with Metabolic Syndrome Traits
title_fullStr	APOE ɛ4 Is Associated with Postprandial Inflammation in Older Adults with Metabolic Syndrome Traits
title_full_unstemmed	APOE ɛ4 Is Associated with Postprandial Inflammation in Older Adults with Metabolic Syndrome Traits
title_sort	apoe ɛ4 is associated with postprandial inflammation in older adults with metabolic syndrome traits
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/da3e177c14074d6a8a943c18eb731598
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APOE ɛ4 Is Associated with Postprandial Inflammation in Older Adults with Metabolic Syndrome Traits

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