Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma

Kras activation and p16 inactivation cooperatively promote pancreatic cancer progression. Here, the authors show that such cooperation depends upon an increased expression of the NAD(P)H oxidase NOX4 achieved through transcription factors independently regulated by the two oncogenic genetic alterati...

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Autores principales:	Huai-Qiang Ju, Haoqiang Ying, Tian Tian, Jianhua Ling, Jie Fu, Yu Lu, Min Wu, Lifeng Yang, Abhinav Achreja, Gang Chen, Zhuonan Zhuang, Huamin Wang, Deepak Nagrath, Jun Yao, Mien-Chie Hung, Ronald A. DePinho, Peng Huang, Rui-Hua Xu, Paul J. Chiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/da3fdd9ee37641f7b1f60225dc58f787
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spelling	oai:doaj.org-article:da3fdd9ee37641f7b1f60225dc58f7872021-12-02T14:42:19ZMutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma10.1038/ncomms144372041-1723https://doaj.org/article/da3fdd9ee37641f7b1f60225dc58f7872017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14437https://doaj.org/toc/2041-1723Kras activation and p16 inactivation cooperatively promote pancreatic cancer progression. Here, the authors show that such cooperation depends upon an increased expression of the NAD(P)H oxidase NOX4 achieved through transcription factors independently regulated by the two oncogenic genetic alterations.Huai-Qiang JuHaoqiang YingTian TianJianhua LingJie FuYu LuMin WuLifeng YangAbhinav AchrejaGang ChenZhuonan ZhuangHuamin WangDeepak NagrathJun YaoMien-Chie HungRonald A. DePinhoPeng HuangRui-Hua XuPaul J. ChiaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huai-Qiang Ju Haoqiang Ying Tian Tian Jianhua Ling Jie Fu Yu Lu Min Wu Lifeng Yang Abhinav Achreja Gang Chen Zhuonan Zhuang Huamin Wang Deepak Nagrath Jun Yao Mien-Chie Hung Ronald A. DePinho Peng Huang Rui-Hua Xu Paul J. Chiao Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma
description	Kras activation and p16 inactivation cooperatively promote pancreatic cancer progression. Here, the authors show that such cooperation depends upon an increased expression of the NAD(P)H oxidase NOX4 achieved through transcription factors independently regulated by the two oncogenic genetic alterations.
format	article
author	Huai-Qiang Ju Haoqiang Ying Tian Tian Jianhua Ling Jie Fu Yu Lu Min Wu Lifeng Yang Abhinav Achreja Gang Chen Zhuonan Zhuang Huamin Wang Deepak Nagrath Jun Yao Mien-Chie Hung Ronald A. DePinho Peng Huang Rui-Hua Xu Paul J. Chiao
author_facet	Huai-Qiang Ju Haoqiang Ying Tian Tian Jianhua Ling Jie Fu Yu Lu Min Wu Lifeng Yang Abhinav Achreja Gang Chen Zhuonan Zhuang Huamin Wang Deepak Nagrath Jun Yao Mien-Chie Hung Ronald A. DePinho Peng Huang Rui-Hua Xu Paul J. Chiao
author_sort	Huai-Qiang Ju
title	Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma
title_short	Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma
title_full	Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma
title_fullStr	Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma
title_full_unstemmed	Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma
title_sort	mutant kras- and p16-regulated nox4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/da3fdd9ee37641f7b1f60225dc58f787
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Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma

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