Abnormal position of lymph nodes in a freemartin sheep

Angela M Gonella-Diaza, Luz Zoraya Duarte, Sergio Dominguez, Pedro A SalazarCl&iacute;nica de Grandes Animales, Facultad de Medicina Veterinaria y de Zootecnia, Universidad Cooperativa de Colombia, Bucaramanga, Santander, ColombiaAbstract: In this freemartin case report the authors present t...

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Autores principales:	Salazar PA, Dominguez S, Duarte LZ, Gonella-Diaza AM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/da42d30c1b6744e4a54c1c50f7f14dd0
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spelling	oai:doaj.org-article:da42d30c1b6744e4a54c1c50f7f14dd02021-12-02T02:38:12ZAbnormal position of lymph nodes in a freemartin sheep2230-2034https://doaj.org/article/da42d30c1b6744e4a54c1c50f7f14dd02012-03-01T00:00:00Zhttp://www.dovepress.com/abnormal-position-of-lymph-nodes-in-a-freemartin-sheep-a9385https://doaj.org/toc/2230-2034Angela M Gonella-Diaza, Luz Zoraya Duarte, Sergio Dominguez, Pedro A SalazarCl&iacute;nica de Grandes Animales, Facultad de Medicina Veterinaria y de Zootecnia, Universidad Cooperativa de Colombia, Bucaramanga, Santander, ColombiaAbstract: In this freemartin case report the authors present the clinical and morphological findings of a freemartin ewe with an abnormal position of two lymph nodes. Freemartins, infertile females from mixed-sex twin pregnancies, are chimeras, having two cell populations: one of their own (XX DNA) and one from their male twin (XY DNA). Freemartins can have varying degrees of phenotypic masculinization, including, in some cases, having active male gonads and exhibiting male behaviors such as heat detection and aggressiveness. During the clinical examination of the freemartin ewe, a morphological abnormality of the vulva, the presence of scrotal sacs, and a lack of mammary tissue development were noted. On inspection of the vaginal channel, an extremely enlarged clitoris, resembling a penis, was found. The clinical evidence suggested freemartinism. After the karyotyping diagnosis confirmation, a necropsy was performed and samples were taken for histology and immunohistochemistry. There were two structures found in the scrotal sacs; however, these were found to be lymph nodes, not testicles, and this was confirmed by CD3 lymph protein coloration. On histological study, the phallic structure showed corpus cavernosum and tunica albuginea. The testicles were found retained inside the abdominal cavity, with the presence of atrophic seminiferous tubules. Although the position of the testicles in freemartins has been reported as highly variable, this is the first time, to the best of the authors&#39; knowledge, that a case has been reported where lymph nodes have been found inside the scrotal sacs. It is possible that these were the inguinal lymph nodes, trapped inside the scrotum during fetal growth and development.Keywords: freemartinism, chimera, ewe, vulva, testesSalazar PADominguez SDuarte LZGonella-Diaza AMDove Medical PressarticleVeterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol 2012, Iss default, Pp 1-6 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Veterinary medicine SF600-1100
spellingShingle	Veterinary medicine SF600-1100 Salazar PA Dominguez S Duarte LZ Gonella-Diaza AM Abnormal position of lymph nodes in a freemartin sheep
description	Angela M Gonella-Diaza, Luz Zoraya Duarte, Sergio Dominguez, Pedro A SalazarCl&iacute;nica de Grandes Animales, Facultad de Medicina Veterinaria y de Zootecnia, Universidad Cooperativa de Colombia, Bucaramanga, Santander, ColombiaAbstract: In this freemartin case report the authors present the clinical and morphological findings of a freemartin ewe with an abnormal position of two lymph nodes. Freemartins, infertile females from mixed-sex twin pregnancies, are chimeras, having two cell populations: one of their own (XX DNA) and one from their male twin (XY DNA). Freemartins can have varying degrees of phenotypic masculinization, including, in some cases, having active male gonads and exhibiting male behaviors such as heat detection and aggressiveness. During the clinical examination of the freemartin ewe, a morphological abnormality of the vulva, the presence of scrotal sacs, and a lack of mammary tissue development were noted. On inspection of the vaginal channel, an extremely enlarged clitoris, resembling a penis, was found. The clinical evidence suggested freemartinism. After the karyotyping diagnosis confirmation, a necropsy was performed and samples were taken for histology and immunohistochemistry. There were two structures found in the scrotal sacs; however, these were found to be lymph nodes, not testicles, and this was confirmed by CD3 lymph protein coloration. On histological study, the phallic structure showed corpus cavernosum and tunica albuginea. The testicles were found retained inside the abdominal cavity, with the presence of atrophic seminiferous tubules. Although the position of the testicles in freemartins has been reported as highly variable, this is the first time, to the best of the authors&#39; knowledge, that a case has been reported where lymph nodes have been found inside the scrotal sacs. It is possible that these were the inguinal lymph nodes, trapped inside the scrotum during fetal growth and development.Keywords: freemartinism, chimera, ewe, vulva, testes
format	article
author	Salazar PA Dominguez S Duarte LZ Gonella-Diaza AM
author_facet	Salazar PA Dominguez S Duarte LZ Gonella-Diaza AM
author_sort	Salazar PA
title	Abnormal position of lymph nodes in a freemartin sheep
title_short	Abnormal position of lymph nodes in a freemartin sheep
title_full	Abnormal position of lymph nodes in a freemartin sheep
title_fullStr	Abnormal position of lymph nodes in a freemartin sheep
title_full_unstemmed	Abnormal position of lymph nodes in a freemartin sheep
title_sort	abnormal position of lymph nodes in a freemartin sheep
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/da42d30c1b6744e4a54c1c50f7f14dd0
work_keys_str_mv	AT salazarpa abnormalpositionoflymphnodesinafreemartinsheep AT dominguezs abnormalpositionoflymphnodesinafreemartinsheep AT duartelz abnormalpositionoflymphnodesinafreemartinsheep AT gonelladiazaam abnormalpositionoflymphnodesinafreemartinsheep
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Abnormal position of lymph nodes in a freemartin sheep

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