Delayed fractional dose regimen of the RTS,S/AS01 malaria vaccine candidate enhances an IgG4 response that inhibits serum opsonophagocytosis

Delayed fractional dose regimen of the RTS,S/AS01 malaria vaccine candidate enhances an IgG4 response that inhibits serum opsonophagocytosis

Abstract A recent study of the RTS,S malaria vaccine, which is based on the circumsporozoite protein (CSP), demonstrated an increase in efficacy from 50–60% to 80% when using a delayed fractional dose regimen, in which the standard 0–1–2 month immunization schedule was modified to a 0–1–7 month sche...

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Bibliographic Details
Main Authors: Sidhartha Chaudhury, Jason A. Regules, Christian A. Darko, Sheetij Dutta, Anders Wallqvist, Norman C. Waters, Erik Jongert, Franck Lemiale, Elke S. Bergmann-Leitner
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/da43572f2ab14d5da906e3ca77074fd9
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https://doaj.org/article/da43572f2ab14d5da906e3ca77074fd9

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