Association of proportion of the HDL-cholesterol subclasses HDL-2b and HDL-3 and macrovascular events among patients undergoing hemodialysis

Abstract Altered high-density lipoprotein cholesterol (HDL-C) subclass distribution in hemodialysis (HD) patients is well documented. Aim of this study is to investigate the relationship between HDL-C subclass distribution and macrovascular events in patients undergoing HD. A total of 164 prevalent...

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Autores principales:	Wen-Chin Lee, Jin-Bor Chen, Sin-Hua Moi, Cheng-Hong Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/da440c059c8c47deaa28df931cfe889e
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spelling	oai:doaj.org-article:da440c059c8c47deaa28df931cfe889e2021-12-02T15:23:39ZAssociation of proportion of the HDL-cholesterol subclasses HDL-2b and HDL-3 and macrovascular events among patients undergoing hemodialysis10.1038/s41598-021-81636-32045-2322https://doaj.org/article/da440c059c8c47deaa28df931cfe889e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81636-3https://doaj.org/toc/2045-2322Abstract Altered high-density lipoprotein cholesterol (HDL-C) subclass distribution in hemodialysis (HD) patients is well documented. Aim of this study is to investigate the relationship between HDL-C subclass distribution and macrovascular events in patients undergoing HD. A total of 164 prevalent HD patients and 71 healthy individuals in one hospital-facilitated clinic were enrolled from May 2019 to July 2019 and individual HD patients was follow-up for one year. Macrovascular events (cerebral stroke, coronary heart disease) were recorded in the study period. The HDL-2b, HDL-3 proportions and biochemical parameters were measured. Pearson correlation test and logistic regression analysis were used to examine correlation and odds ratio (OR). 144 HD patients completed one-year follow-up. Cohort with macrovascular events revealed significantly lower HDL-2b and higher HDL-3 subclass proportions compared to those without events. By multivariable adjustment, HDL-3 subclass proportion revealed significantly increase risk for these events (OR 1.17, 95% CI 1.02–1.41, P = 0.044). HDL-2b subclass was significantly higher and HDL-3 subclass was significantly lower in the HD cohort under the hs-CRP level of < 3 mg/L compared to higher hs-CRP level. In conclusion, HDL-2b and HDL-3 subclasses distributions were associated with macrovascular events in HD patients. Proinflammatory status influences the distribution of HDL-2b and HDL-3 subclasses in HD patients.Wen-Chin LeeJin-Bor ChenSin-Hua MoiCheng-Hong YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wen-Chin Lee Jin-Bor Chen Sin-Hua Moi Cheng-Hong Yang Association of proportion of the HDL-cholesterol subclasses HDL-2b and HDL-3 and macrovascular events among patients undergoing hemodialysis
description	Abstract Altered high-density lipoprotein cholesterol (HDL-C) subclass distribution in hemodialysis (HD) patients is well documented. Aim of this study is to investigate the relationship between HDL-C subclass distribution and macrovascular events in patients undergoing HD. A total of 164 prevalent HD patients and 71 healthy individuals in one hospital-facilitated clinic were enrolled from May 2019 to July 2019 and individual HD patients was follow-up for one year. Macrovascular events (cerebral stroke, coronary heart disease) were recorded in the study period. The HDL-2b, HDL-3 proportions and biochemical parameters were measured. Pearson correlation test and logistic regression analysis were used to examine correlation and odds ratio (OR). 144 HD patients completed one-year follow-up. Cohort with macrovascular events revealed significantly lower HDL-2b and higher HDL-3 subclass proportions compared to those without events. By multivariable adjustment, HDL-3 subclass proportion revealed significantly increase risk for these events (OR 1.17, 95% CI 1.02–1.41, P = 0.044). HDL-2b subclass was significantly higher and HDL-3 subclass was significantly lower in the HD cohort under the hs-CRP level of < 3 mg/L compared to higher hs-CRP level. In conclusion, HDL-2b and HDL-3 subclasses distributions were associated with macrovascular events in HD patients. Proinflammatory status influences the distribution of HDL-2b and HDL-3 subclasses in HD patients.
format	article
author	Wen-Chin Lee Jin-Bor Chen Sin-Hua Moi Cheng-Hong Yang
author_facet	Wen-Chin Lee Jin-Bor Chen Sin-Hua Moi Cheng-Hong Yang
author_sort	Wen-Chin Lee
title	Association of proportion of the HDL-cholesterol subclasses HDL-2b and HDL-3 and macrovascular events among patients undergoing hemodialysis
title_short	Association of proportion of the HDL-cholesterol subclasses HDL-2b and HDL-3 and macrovascular events among patients undergoing hemodialysis
title_full	Association of proportion of the HDL-cholesterol subclasses HDL-2b and HDL-3 and macrovascular events among patients undergoing hemodialysis
title_fullStr	Association of proportion of the HDL-cholesterol subclasses HDL-2b and HDL-3 and macrovascular events among patients undergoing hemodialysis
title_full_unstemmed	Association of proportion of the HDL-cholesterol subclasses HDL-2b and HDL-3 and macrovascular events among patients undergoing hemodialysis
title_sort	association of proportion of the hdl-cholesterol subclasses hdl-2b and hdl-3 and macrovascular events among patients undergoing hemodialysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/da440c059c8c47deaa28df931cfe889e
work_keys_str_mv	AT wenchinlee associationofproportionofthehdlcholesterolsubclasseshdl2bandhdl3andmacrovasculareventsamongpatientsundergoinghemodialysis AT jinborchen associationofproportionofthehdlcholesterolsubclasseshdl2bandhdl3andmacrovasculareventsamongpatientsundergoinghemodialysis AT sinhuamoi associationofproportionofthehdlcholesterolsubclasseshdl2bandhdl3andmacrovasculareventsamongpatientsundergoinghemodialysis AT chenghongyang associationofproportionofthehdlcholesterolsubclasseshdl2bandhdl3andmacrovasculareventsamongpatientsundergoinghemodialysis
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Association of proportion of the HDL-cholesterol subclasses HDL-2b and HDL-3 and macrovascular events among patients undergoing hemodialysis

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