Gut-associated IgA+ immune cells regulate obesity-related insulin resistance

Gut-associated IgA+ immune cells regulate obesity-related insulin resistance

The effect of diet-induced obesity on intestinal B cell populations is not well understood despite emerging evidence of a critical role for the intestinal immune system in contributing to insulin resistance. Here, the authors show important functions of IgA in regulating metabolic disease and for in...

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Autores principales: Helen Luck, Saad Khan, Justin H. Kim, Julia K. Copeland, Xavier S. Revelo, Sue Tsai, Mainak Chakraborty, Kathleen Cheng, Yi Tao Chan, Mark K. Nøhr, Xavier Clemente-Casares, Marie-Christine Perry, Magar Ghazarian, Helena Lei, Yi-Hsuan Lin, Bryan Coburn, Allan Okrainec, Timothy Jackson, Susan Poutanen, Herbert Gaisano, Johane P. Allard, David S. Guttman, Margaret E. Conner, Shawn Winer, Daniel A. Winer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/da441e250e21423db8dd1a9346ba29eb
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Sumario:The effect of diet-induced obesity on intestinal B cell populations is not well understood despite emerging evidence of a critical role for the intestinal immune system in contributing to insulin resistance. Here, the authors show important functions of IgA in regulating metabolic disease and for intestinal immunity in modulating systemic glucose metabolism.

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