Gut-associated IgA+ immune cells regulate obesity-related insulin resistance

The effect of diet-induced obesity on intestinal B cell populations is not well understood despite emerging evidence of a critical role for the intestinal immune system in contributing to insulin resistance. Here, the authors show important functions of IgA in regulating metabolic disease and for in...

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Autores principales:	Helen Luck, Saad Khan, Justin H. Kim, Julia K. Copeland, Xavier S. Revelo, Sue Tsai, Mainak Chakraborty, Kathleen Cheng, Yi Tao Chan, Mark K. Nøhr, Xavier Clemente-Casares, Marie-Christine Perry, Magar Ghazarian, Helena Lei, Yi-Hsuan Lin, Bryan Coburn, Allan Okrainec, Timothy Jackson, Susan Poutanen, Herbert Gaisano, Johane P. Allard, David S. Guttman, Margaret E. Conner, Shawn Winer, Daniel A. Winer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/da441e250e21423db8dd1a9346ba29eb
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spelling	oai:doaj.org-article:da441e250e21423db8dd1a9346ba29eb2021-12-02T17:02:07ZGut-associated IgA+ immune cells regulate obesity-related insulin resistance10.1038/s41467-019-11370-y2041-1723https://doaj.org/article/da441e250e21423db8dd1a9346ba29eb2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11370-yhttps://doaj.org/toc/2041-1723The effect of diet-induced obesity on intestinal B cell populations is not well understood despite emerging evidence of a critical role for the intestinal immune system in contributing to insulin resistance. Here, the authors show important functions of IgA in regulating metabolic disease and for intestinal immunity in modulating systemic glucose metabolism.Helen LuckSaad KhanJustin H. KimJulia K. CopelandXavier S. ReveloSue TsaiMainak ChakrabortyKathleen ChengYi Tao ChanMark K. NøhrXavier Clemente-CasaresMarie-Christine PerryMagar GhazarianHelena LeiYi-Hsuan LinBryan CoburnAllan OkrainecTimothy JacksonSusan PoutanenHerbert GaisanoJohane P. AllardDavid S. GuttmanMargaret E. ConnerShawn WinerDaniel A. WinerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Helen Luck Saad Khan Justin H. Kim Julia K. Copeland Xavier S. Revelo Sue Tsai Mainak Chakraborty Kathleen Cheng Yi Tao Chan Mark K. Nøhr Xavier Clemente-Casares Marie-Christine Perry Magar Ghazarian Helena Lei Yi-Hsuan Lin Bryan Coburn Allan Okrainec Timothy Jackson Susan Poutanen Herbert Gaisano Johane P. Allard David S. Guttman Margaret E. Conner Shawn Winer Daniel A. Winer Gut-associated IgA+ immune cells regulate obesity-related insulin resistance
description	The effect of diet-induced obesity on intestinal B cell populations is not well understood despite emerging evidence of a critical role for the intestinal immune system in contributing to insulin resistance. Here, the authors show important functions of IgA in regulating metabolic disease and for intestinal immunity in modulating systemic glucose metabolism.
format	article
author	Helen Luck Saad Khan Justin H. Kim Julia K. Copeland Xavier S. Revelo Sue Tsai Mainak Chakraborty Kathleen Cheng Yi Tao Chan Mark K. Nøhr Xavier Clemente-Casares Marie-Christine Perry Magar Ghazarian Helena Lei Yi-Hsuan Lin Bryan Coburn Allan Okrainec Timothy Jackson Susan Poutanen Herbert Gaisano Johane P. Allard David S. Guttman Margaret E. Conner Shawn Winer Daniel A. Winer
author_facet	Helen Luck Saad Khan Justin H. Kim Julia K. Copeland Xavier S. Revelo Sue Tsai Mainak Chakraborty Kathleen Cheng Yi Tao Chan Mark K. Nøhr Xavier Clemente-Casares Marie-Christine Perry Magar Ghazarian Helena Lei Yi-Hsuan Lin Bryan Coburn Allan Okrainec Timothy Jackson Susan Poutanen Herbert Gaisano Johane P. Allard David S. Guttman Margaret E. Conner Shawn Winer Daniel A. Winer
author_sort	Helen Luck
title	Gut-associated IgA+ immune cells regulate obesity-related insulin resistance
title_short	Gut-associated IgA+ immune cells regulate obesity-related insulin resistance
title_full	Gut-associated IgA+ immune cells regulate obesity-related insulin resistance
title_fullStr	Gut-associated IgA+ immune cells regulate obesity-related insulin resistance
title_full_unstemmed	Gut-associated IgA+ immune cells regulate obesity-related insulin resistance
title_sort	gut-associated iga+ immune cells regulate obesity-related insulin resistance
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/da441e250e21423db8dd1a9346ba29eb
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Gut-associated IgA+ immune cells regulate obesity-related insulin resistance

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