Selenium as a pleiotropic agent for medical discovery and drug delivery

Baozhang Guan,1,* Ruiling Yan,2,* Ruiman Li,3 Xingwang Zhang4 1Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, China; 2Fetal Medicine Department, The First Affiliated Hospital of Jinan University, Guangzhou, China; 3Department of Gynecology and Obstetrics, Th...

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Autores principales:	Guan BZ, Yan RL, Li RM, Zhang X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Selenium selenium nanoparticles nanomedicine biomedical applications drug delivery oncotherapy diabetes. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/da4943a492904b438a449150d6350ae3
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spelling	oai:doaj.org-article:da4943a492904b438a449150d6350ae32021-12-02T07:56:32ZSelenium as a pleiotropic agent for medical discovery and drug delivery1178-2013https://doaj.org/article/da4943a492904b438a449150d6350ae32018-11-01T00:00:00Zhttps://www.dovepress.com/selenium-as-a-pleiotropic-agent-for-medical-discovery-and-drug-deliver-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Baozhang Guan,1,* Ruiling Yan,2,* Ruiman Li,3 Xingwang Zhang4 1Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, China; 2Fetal Medicine Department, The First Affiliated Hospital of Jinan University, Guangzhou, China; 3Department of Gynecology and Obstetrics, The First Affiliated Hospital of Jinan University, Guangzhou, China; 4Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou, China *These authors contributed equally to this work Abstract: Selenium as a biologically active element lends much support to health maintenance and disease prevention. It is now presenting pleiotropic effects on therapy and drug delivery. In this study, a profiling on the physiological functions, therapeutic significances, clinical/preclinical performances, and biomedical and drug delivery applications of selenium in different modalities was carried out. Major interests focused on selenium-based nanomedicines in confronting various diseases pertaining to selenium or not, especially in antitumor and antidiabetes. Furthermore, the article exclusively discusses selenium nanoparticles featured by ameliorative functions with emphasis on their applications in medical practice and drug delivery. The state-of-the-art in medical discovery as well as research and development on selenium and nano-selenium is discussed in this review. Keywords: selenium, selenium nanoparticles, nanomedicine, biomedical applications, drug delivery, oncotherapy, diabetesGuan BZYan RLLi RMZhang XDove Medical PressarticleSeleniumselenium nanoparticlesnanomedicinebiomedical applicationsdrug deliveryoncotherapydiabetes.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 7473-7490 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Selenium selenium nanoparticles nanomedicine biomedical applications drug delivery oncotherapy diabetes. Medicine (General) R5-920
spellingShingle	Selenium selenium nanoparticles nanomedicine biomedical applications drug delivery oncotherapy diabetes. Medicine (General) R5-920 Guan BZ Yan RL Li RM Zhang X Selenium as a pleiotropic agent for medical discovery and drug delivery
description	Baozhang Guan,1,* Ruiling Yan,2,* Ruiman Li,3 Xingwang Zhang4 1Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, China; 2Fetal Medicine Department, The First Affiliated Hospital of Jinan University, Guangzhou, China; 3Department of Gynecology and Obstetrics, The First Affiliated Hospital of Jinan University, Guangzhou, China; 4Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou, China *These authors contributed equally to this work Abstract: Selenium as a biologically active element lends much support to health maintenance and disease prevention. It is now presenting pleiotropic effects on therapy and drug delivery. In this study, a profiling on the physiological functions, therapeutic significances, clinical/preclinical performances, and biomedical and drug delivery applications of selenium in different modalities was carried out. Major interests focused on selenium-based nanomedicines in confronting various diseases pertaining to selenium or not, especially in antitumor and antidiabetes. Furthermore, the article exclusively discusses selenium nanoparticles featured by ameliorative functions with emphasis on their applications in medical practice and drug delivery. The state-of-the-art in medical discovery as well as research and development on selenium and nano-selenium is discussed in this review. Keywords: selenium, selenium nanoparticles, nanomedicine, biomedical applications, drug delivery, oncotherapy, diabetes
format	article
author	Guan BZ Yan RL Li RM Zhang X
author_facet	Guan BZ Yan RL Li RM Zhang X
author_sort	Guan BZ
title	Selenium as a pleiotropic agent for medical discovery and drug delivery
title_short	Selenium as a pleiotropic agent for medical discovery and drug delivery
title_full	Selenium as a pleiotropic agent for medical discovery and drug delivery
title_fullStr	Selenium as a pleiotropic agent for medical discovery and drug delivery
title_full_unstemmed	Selenium as a pleiotropic agent for medical discovery and drug delivery
title_sort	selenium as a pleiotropic agent for medical discovery and drug delivery
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/da4943a492904b438a449150d6350ae3
work_keys_str_mv	AT guanbz seleniumasapleiotropicagentformedicaldiscoveryanddrugdelivery AT yanrl seleniumasapleiotropicagentformedicaldiscoveryanddrugdelivery AT lirm seleniumasapleiotropicagentformedicaldiscoveryanddrugdelivery AT zhangx seleniumasapleiotropicagentformedicaldiscoveryanddrugdelivery
_version_	1718399132273475584

Selenium as a pleiotropic agent for medical discovery and drug delivery

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