A Systematic Review and Meta-Analysis of the Effect of Statins on Glutathione Peroxidase, Superoxide Dismutase, and Catalase

Statins may exert protective effects against oxidative stress by upregulating specific antioxidant mechanisms. We conducted a systematic review and meta-analysis of the effect of statins on three key antioxidant enzymes: glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase. The ele...

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Autores principales:	Angelo Zinellu, Arduino A. Mangoni
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	statins glutathione peroxidase superoxide dismutase catalase oxidative stress pleiotropic effects Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/da4a300899094cc29f31355a9831f8f9
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spelling	oai:doaj.org-article:da4a300899094cc29f31355a9831f8f92021-11-25T16:29:41ZA Systematic Review and Meta-Analysis of the Effect of Statins on Glutathione Peroxidase, Superoxide Dismutase, and Catalase10.3390/antiox101118412076-3921https://doaj.org/article/da4a300899094cc29f31355a9831f8f92021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1841https://doaj.org/toc/2076-3921Statins may exert protective effects against oxidative stress by upregulating specific antioxidant mechanisms. We conducted a systematic review and meta-analysis of the effect of statins on three key antioxidant enzymes: glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase. The electronic databases PubMed, Web of Science, and Scopus were searched from inception to July 2021. The risk of bias was assessed with the Joanna Briggs Institute Critical Appraisal Checklist and certainty of evidence was assessed using the GRADE framework. In 15 studies, reporting 17 treatment arms in 773 patients (mean age 53 years, 54% males), statins significantly increased the concentrations of both GPx (standardized mean difference, SMD = 0.80, 95% confidence interval, CI 0.13 to 1.46, <i>p</i> = 0.018; high certainty of evidence) and SOD (SMD = 1.54, 95% CI 0.71 to 2.36, <i>p</i> < 0.001; high certainty of evidence), but not catalase (SMD = −0.16, 95% CI −0.51 to 0.20, <i>p</i> = 0.394; very low certainty of evidence). The pooled SMD values were not altered in sensitivity analysis. There was no publication bias. In conclusion, statin treatment significantly increases the circulating concentrations of GPx and SOD, suggesting an antioxidant effect of these agents (PROSPERO registration number: CRD42021271589).Angelo ZinelluArduino A. MangoniMDPI AGarticlestatinsglutathione peroxidasesuperoxide dismutasecatalaseoxidative stresspleiotropic effectsTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1841, p 1841 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	statins glutathione peroxidase superoxide dismutase catalase oxidative stress pleiotropic effects Therapeutics. Pharmacology RM1-950
spellingShingle	statins glutathione peroxidase superoxide dismutase catalase oxidative stress pleiotropic effects Therapeutics. Pharmacology RM1-950 Angelo Zinellu Arduino A. Mangoni A Systematic Review and Meta-Analysis of the Effect of Statins on Glutathione Peroxidase, Superoxide Dismutase, and Catalase
description	Statins may exert protective effects against oxidative stress by upregulating specific antioxidant mechanisms. We conducted a systematic review and meta-analysis of the effect of statins on three key antioxidant enzymes: glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase. The electronic databases PubMed, Web of Science, and Scopus were searched from inception to July 2021. The risk of bias was assessed with the Joanna Briggs Institute Critical Appraisal Checklist and certainty of evidence was assessed using the GRADE framework. In 15 studies, reporting 17 treatment arms in 773 patients (mean age 53 years, 54% males), statins significantly increased the concentrations of both GPx (standardized mean difference, SMD = 0.80, 95% confidence interval, CI 0.13 to 1.46, <i>p</i> = 0.018; high certainty of evidence) and SOD (SMD = 1.54, 95% CI 0.71 to 2.36, <i>p</i> < 0.001; high certainty of evidence), but not catalase (SMD = −0.16, 95% CI −0.51 to 0.20, <i>p</i> = 0.394; very low certainty of evidence). The pooled SMD values were not altered in sensitivity analysis. There was no publication bias. In conclusion, statin treatment significantly increases the circulating concentrations of GPx and SOD, suggesting an antioxidant effect of these agents (PROSPERO registration number: CRD42021271589).
format	article
author	Angelo Zinellu Arduino A. Mangoni
author_facet	Angelo Zinellu Arduino A. Mangoni
author_sort	Angelo Zinellu
title	A Systematic Review and Meta-Analysis of the Effect of Statins on Glutathione Peroxidase, Superoxide Dismutase, and Catalase
title_short	A Systematic Review and Meta-Analysis of the Effect of Statins on Glutathione Peroxidase, Superoxide Dismutase, and Catalase
title_full	A Systematic Review and Meta-Analysis of the Effect of Statins on Glutathione Peroxidase, Superoxide Dismutase, and Catalase
title_fullStr	A Systematic Review and Meta-Analysis of the Effect of Statins on Glutathione Peroxidase, Superoxide Dismutase, and Catalase
title_full_unstemmed	A Systematic Review and Meta-Analysis of the Effect of Statins on Glutathione Peroxidase, Superoxide Dismutase, and Catalase
title_sort	systematic review and meta-analysis of the effect of statins on glutathione peroxidase, superoxide dismutase, and catalase
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/da4a300899094cc29f31355a9831f8f9
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A Systematic Review and Meta-Analysis of the Effect of Statins on Glutathione Peroxidase, Superoxide Dismutase, and Catalase

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