Probiotics maintain the gut microbiome homeostasis during Indian Antarctic expedition by ship

Abstract Ship voyage to Antarctica is a stressful journey for expedition members. The response of human gut microbiota to ship voyage and a feasible approach to maintain gut health, is still unexplored. The present findings describe a 24-day long longitudinal study involving 19 members from 38th Ind...

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Autores principales:	Ashish Kumar Srivastava, Vishwajeet Rohil, Brij Bhushan, Malleswara Rao Eslavath, Harshita Gupta, Sudipta Chanda, Bhuvnesh Kumar, Rajeev Varshney, Lilly Ganju
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/da4d96cfec544cb18e65259be37b0a1e
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spelling	oai:doaj.org-article:da4d96cfec544cb18e65259be37b0a1e2021-12-02T18:14:16ZProbiotics maintain the gut microbiome homeostasis during Indian Antarctic expedition by ship10.1038/s41598-021-97890-42045-2322https://doaj.org/article/da4d96cfec544cb18e65259be37b0a1e2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97890-4https://doaj.org/toc/2045-2322Abstract Ship voyage to Antarctica is a stressful journey for expedition members. The response of human gut microbiota to ship voyage and a feasible approach to maintain gut health, is still unexplored. The present findings describe a 24-day long longitudinal study involving 19 members from 38th Indian Antarctic Expedition, to investigate the impact of ship voyage and effect of probiotic intervention on gut microbiota. Fecal samples collected on day 0 as baseline and at the end of ship voyage (day 24), were analyzed using whole genome shotgun sequencing. Probiotic intervention reduced the sea sickness by 10% compared to 44% in placebo group. The gut microbiome in placebo group members on day 0 and day 24, indicated significant alteration compared to a marginal change in the microbial composition in probiotic group. Functional analysis revealed significant alterations in carbohydrate and amino acid metabolism. Carbohydrate-active enzymes analysis represented functional genes involved in glycoside hydrolases, glycosyltransferases and carbohydrate binding modules, for maintaining gut microbiome homeostasis. Suggesting thereby the possible mechanism of probiotic in stabilizing and restoring gut microflora during stressful ship journey. The present study is first of its kind, providing a feasible approach for protecting gut health during Antarctic expedition involving ship voyage.Ashish Kumar SrivastavaVishwajeet RohilBrij BhushanMalleswara Rao EslavathHarshita GuptaSudipta ChandaBhuvnesh KumarRajeev VarshneyLilly GanjuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ashish Kumar Srivastava Vishwajeet Rohil Brij Bhushan Malleswara Rao Eslavath Harshita Gupta Sudipta Chanda Bhuvnesh Kumar Rajeev Varshney Lilly Ganju Probiotics maintain the gut microbiome homeostasis during Indian Antarctic expedition by ship
description	Abstract Ship voyage to Antarctica is a stressful journey for expedition members. The response of human gut microbiota to ship voyage and a feasible approach to maintain gut health, is still unexplored. The present findings describe a 24-day long longitudinal study involving 19 members from 38th Indian Antarctic Expedition, to investigate the impact of ship voyage and effect of probiotic intervention on gut microbiota. Fecal samples collected on day 0 as baseline and at the end of ship voyage (day 24), were analyzed using whole genome shotgun sequencing. Probiotic intervention reduced the sea sickness by 10% compared to 44% in placebo group. The gut microbiome in placebo group members on day 0 and day 24, indicated significant alteration compared to a marginal change in the microbial composition in probiotic group. Functional analysis revealed significant alterations in carbohydrate and amino acid metabolism. Carbohydrate-active enzymes analysis represented functional genes involved in glycoside hydrolases, glycosyltransferases and carbohydrate binding modules, for maintaining gut microbiome homeostasis. Suggesting thereby the possible mechanism of probiotic in stabilizing and restoring gut microflora during stressful ship journey. The present study is first of its kind, providing a feasible approach for protecting gut health during Antarctic expedition involving ship voyage.
format	article
author	Ashish Kumar Srivastava Vishwajeet Rohil Brij Bhushan Malleswara Rao Eslavath Harshita Gupta Sudipta Chanda Bhuvnesh Kumar Rajeev Varshney Lilly Ganju
author_facet	Ashish Kumar Srivastava Vishwajeet Rohil Brij Bhushan Malleswara Rao Eslavath Harshita Gupta Sudipta Chanda Bhuvnesh Kumar Rajeev Varshney Lilly Ganju
author_sort	Ashish Kumar Srivastava
title	Probiotics maintain the gut microbiome homeostasis during Indian Antarctic expedition by ship
title_short	Probiotics maintain the gut microbiome homeostasis during Indian Antarctic expedition by ship
title_full	Probiotics maintain the gut microbiome homeostasis during Indian Antarctic expedition by ship
title_fullStr	Probiotics maintain the gut microbiome homeostasis during Indian Antarctic expedition by ship
title_full_unstemmed	Probiotics maintain the gut microbiome homeostasis during Indian Antarctic expedition by ship
title_sort	probiotics maintain the gut microbiome homeostasis during indian antarctic expedition by ship
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/da4d96cfec544cb18e65259be37b0a1e
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Probiotics maintain the gut microbiome homeostasis during Indian Antarctic expedition by ship

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