The importance of norepinephrine in depression

Chantal Moret, Mike BrileyNeuroBiz Consulting and Communication, Castres, FranceAbstract: Depression is one of the most common psychological diseases with significant potential morbidity and mortality. Although the underlying pathophysiology of depression has not been clearly defined, preclinical an...

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Autores principales:	Moret C, Briley M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/da4ef1f7eefc4c66b41dd34418c9ddcf
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spelling	oai:doaj.org-article:da4ef1f7eefc4c66b41dd34418c9ddcf2021-12-02T06:02:06ZThe importance of norepinephrine in depression1176-63281178-2021https://doaj.org/article/da4ef1f7eefc4c66b41dd34418c9ddcf2011-05-01T00:00:00Zhttp://www.dovepress.com/the-importance-of-norepinephrine-in-depression-a7567https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Chantal Moret, Mike BrileyNeuroBiz Consulting and Communication, Castres, FranceAbstract: Depression is one of the most common psychological diseases with significant potential morbidity and mortality. Although the underlying pathophysiology of depression has not been clearly defined, preclinical and clinical evidence suggest disturbances in serotonin (5-HT), norepinephrine (NE), and dopamine (DA) neurotransmission in the central nervous system. Virtually all currently available antidepressants act on one or more of the following mechanisms: inhibition of reuptake of 5-HT or NE (and DA), antagonism of inhibitory presynaptic 5-HT or NE receptors, or inhibition of monoamine oxidase. All of these mechanisms result in an enhanced neurotransmission of 5-HT and/or NE. Evidence for the involvement of NE in depression is abundant, and recent studies on neuronal pathways and symptoms highlight the specific role of NE in this disorder. NE plays a determinant role in executive functioning regulating cognition, motivation, and intellect, which are fundamental in social relationships. Social dysfunction is possibly one of the most important factors affecting the quality of life in depressed patients.Keywords: serotonin, antidepressants, neurotransmission, symptomsMoret CBriley MDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2011, Iss Supplement 1, Pp 9-13 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Moret C Briley M The importance of norepinephrine in depression
description	Chantal Moret, Mike BrileyNeuroBiz Consulting and Communication, Castres, FranceAbstract: Depression is one of the most common psychological diseases with significant potential morbidity and mortality. Although the underlying pathophysiology of depression has not been clearly defined, preclinical and clinical evidence suggest disturbances in serotonin (5-HT), norepinephrine (NE), and dopamine (DA) neurotransmission in the central nervous system. Virtually all currently available antidepressants act on one or more of the following mechanisms: inhibition of reuptake of 5-HT or NE (and DA), antagonism of inhibitory presynaptic 5-HT or NE receptors, or inhibition of monoamine oxidase. All of these mechanisms result in an enhanced neurotransmission of 5-HT and/or NE. Evidence for the involvement of NE in depression is abundant, and recent studies on neuronal pathways and symptoms highlight the specific role of NE in this disorder. NE plays a determinant role in executive functioning regulating cognition, motivation, and intellect, which are fundamental in social relationships. Social dysfunction is possibly one of the most important factors affecting the quality of life in depressed patients.Keywords: serotonin, antidepressants, neurotransmission, symptoms
format	article
author	Moret C Briley M
author_facet	Moret C Briley M
author_sort	Moret C
title	The importance of norepinephrine in depression
title_short	The importance of norepinephrine in depression
title_full	The importance of norepinephrine in depression
title_fullStr	The importance of norepinephrine in depression
title_full_unstemmed	The importance of norepinephrine in depression
title_sort	importance of norepinephrine in depression
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/da4ef1f7eefc4c66b41dd34418c9ddcf
work_keys_str_mv	AT moretc theimportanceofnorepinephrineindepression AT brileym theimportanceofnorepinephrineindepression AT moretc importanceofnorepinephrineindepression AT brileym importanceofnorepinephrineindepression
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The importance of norepinephrine in depression

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