Optimization of Magneto-thermally Controlled Release Kinetics by Tuning of Magnetoliposome Composition and Structure

Abstract Stealth (PEGylated) liposomes have taken a central role in drug formulation and delivery combining efficient transport with low nonspecific interactions. Controlling rapid release at a certain location and time remains a challenge dependent on environmental factors. We demonstrate a highly...

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Autores principales:	Behzad Shirmardi Shaghasemi, Mudassar Mumtaz Virk, Erik Reimhult
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/da4f6f0bcceb495da9b134fcc79c6739
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spelling	oai:doaj.org-article:da4f6f0bcceb495da9b134fcc79c67392021-12-02T16:07:57ZOptimization of Magneto-thermally Controlled Release Kinetics by Tuning of Magnetoliposome Composition and Structure10.1038/s41598-017-06980-92045-2322https://doaj.org/article/da4f6f0bcceb495da9b134fcc79c67392017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06980-9https://doaj.org/toc/2045-2322Abstract Stealth (PEGylated) liposomes have taken a central role in drug formulation and delivery combining efficient transport with low nonspecific interactions. Controlling rapid release at a certain location and time remains a challenge dependent on environmental factors. We demonstrate a highly efficient and scalable way to produce liposomes of any lipid composition containing homogeneously dispersed monodisperse superparamagnetic iron oxide nanoparticles in the membrane interior. We investigate the effect of lipid composition, particle concentration and magnetic field actuation on colloidal stability, magneto-thermally actuated release and passive release rates. We show that the rate and amount of encapsulated hydrophilic compound released by actuation using alternating magnetic fields can be precisely controlled from stealth liposomes with high membrane melting temperature. Extraordinarily low passive release and temperature sensitivity at body temperature makes this a promising encapsulation and external-trigger-on-demand release system. The introduced feature can be used as an add-on to existing stealth liposome drug delivery technology.Behzad Shirmardi ShaghasemiMudassar Mumtaz VirkErik ReimhultNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Behzad Shirmardi Shaghasemi Mudassar Mumtaz Virk Erik Reimhult Optimization of Magneto-thermally Controlled Release Kinetics by Tuning of Magnetoliposome Composition and Structure
description	Abstract Stealth (PEGylated) liposomes have taken a central role in drug formulation and delivery combining efficient transport with low nonspecific interactions. Controlling rapid release at a certain location and time remains a challenge dependent on environmental factors. We demonstrate a highly efficient and scalable way to produce liposomes of any lipid composition containing homogeneously dispersed monodisperse superparamagnetic iron oxide nanoparticles in the membrane interior. We investigate the effect of lipid composition, particle concentration and magnetic field actuation on colloidal stability, magneto-thermally actuated release and passive release rates. We show that the rate and amount of encapsulated hydrophilic compound released by actuation using alternating magnetic fields can be precisely controlled from stealth liposomes with high membrane melting temperature. Extraordinarily low passive release and temperature sensitivity at body temperature makes this a promising encapsulation and external-trigger-on-demand release system. The introduced feature can be used as an add-on to existing stealth liposome drug delivery technology.
format	article
author	Behzad Shirmardi Shaghasemi Mudassar Mumtaz Virk Erik Reimhult
author_facet	Behzad Shirmardi Shaghasemi Mudassar Mumtaz Virk Erik Reimhult
author_sort	Behzad Shirmardi Shaghasemi
title	Optimization of Magneto-thermally Controlled Release Kinetics by Tuning of Magnetoliposome Composition and Structure
title_short	Optimization of Magneto-thermally Controlled Release Kinetics by Tuning of Magnetoliposome Composition and Structure
title_full	Optimization of Magneto-thermally Controlled Release Kinetics by Tuning of Magnetoliposome Composition and Structure
title_fullStr	Optimization of Magneto-thermally Controlled Release Kinetics by Tuning of Magnetoliposome Composition and Structure
title_full_unstemmed	Optimization of Magneto-thermally Controlled Release Kinetics by Tuning of Magnetoliposome Composition and Structure
title_sort	optimization of magneto-thermally controlled release kinetics by tuning of magnetoliposome composition and structure
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/da4f6f0bcceb495da9b134fcc79c6739
work_keys_str_mv	AT behzadshirmardishaghasemi optimizationofmagnetothermallycontrolledreleasekineticsbytuningofmagnetoliposomecompositionandstructure AT mudassarmumtazvirk optimizationofmagnetothermallycontrolledreleasekineticsbytuningofmagnetoliposomecompositionandstructure AT erikreimhult optimizationofmagnetothermallycontrolledreleasekineticsbytuningofmagnetoliposomecompositionandstructure
_version_	1718384687137685504

Optimization of Magneto-thermally Controlled Release Kinetics by Tuning of Magnetoliposome Composition and Structure

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