Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming

Abstract Protein SUMOylation is a dynamic post-translational modification shown to be involved in a diverse set of physiologic processes throughout the cell. SUMOylation has also been shown to play a role in the pathobiology of myriad cancers, one of which is glioblastoma multiforme (GBM). As such,...

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Autores principales: Joshua D. Bernstock, Daniel Ye, Florian A. Gessler, Yang-ja Lee, Luca Peruzzotti-Jametti, Peter Baumgarten, Kory R. Johnson, Dragan Maric, Wei Yang, Donat Kögel, Stefano Pluchino, John M. Hallenbeck
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/da4f8bc42ef147c6a124478a1b68ce27
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