Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs

Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs

Simpson, McTiernan et al. develop fully synthetic corneal implants. The resulting CLP-PEG-MPC implants show reduced corneal swelling, haze, and neovascularization compared to CLP-PEG only implants when grafted into a mini-pig cornea alkali burn model of inflammation over 12 months. This study sugges...

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Autores principales: Fiona C. Simpson, Christopher D. McTiernan, Mohammad Mirazul Islam, Oleksiy Buznyk, Philip N. Lewis, Keith M. Meek, Michel Haagdorens, Cindy Audiger, Sylvie Lesage, François-Xavier Gueriot, Isabelle Brunette, Marie-Claude Robert, David Olsen, Laura Koivusalo, Aneta Liszka, Per Fagerholm, Miguel Gonzalez-Andrades, May Griffith
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/da52745a8e174b3fb69db4effa395084
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Sumario:Simpson, McTiernan et al. develop fully synthetic corneal implants. The resulting CLP-PEG-MPC implants show reduced corneal swelling, haze, and neovascularization compared to CLP-PEG only implants when grafted into a mini-pig cornea alkali burn model of inflammation over 12 months. This study suggests the superiority of CLP-PEG-MPC implants over the CLP-PEG only implants.

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