Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs

Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs

Simpson, McTiernan et al. develop fully synthetic corneal implants. The resulting CLP-PEG-MPC implants show reduced corneal swelling, haze, and neovascularization compared to CLP-PEG only implants when grafted into a mini-pig cornea alkali burn model of inflammation over 12 months. This study sugges...

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Autores principales: Fiona C. Simpson, Christopher D. McTiernan, Mohammad Mirazul Islam, Oleksiy Buznyk, Philip N. Lewis, Keith M. Meek, Michel Haagdorens, Cindy Audiger, Sylvie Lesage, François-Xavier Gueriot, Isabelle Brunette, Marie-Claude Robert, David Olsen, Laura Koivusalo, Aneta Liszka, Per Fagerholm, Miguel Gonzalez-Andrades, May Griffith
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/da52745a8e174b3fb69db4effa395084
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spelling oai:doaj.org-article:da52745a8e174b3fb69db4effa3950842021-12-02T14:58:32ZCollagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs10.1038/s42003-021-02108-y2399-3642https://doaj.org/article/da52745a8e174b3fb69db4effa3950842021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02108-yhttps://doaj.org/toc/2399-3642Simpson, McTiernan et al. develop fully synthetic corneal implants. The resulting CLP-PEG-MPC implants show reduced corneal swelling, haze, and neovascularization compared to CLP-PEG only implants when grafted into a mini-pig cornea alkali burn model of inflammation over 12 months. This study suggests the superiority of CLP-PEG-MPC implants over the CLP-PEG only implants.Fiona C. SimpsonChristopher D. McTiernanMohammad Mirazul IslamOleksiy BuznykPhilip N. LewisKeith M. MeekMichel HaagdorensCindy AudigerSylvie LesageFrançois-Xavier GueriotIsabelle BrunetteMarie-Claude RobertDavid OlsenLaura KoivusaloAneta LiszkaPer FagerholmMiguel Gonzalez-AndradesMay GriffithNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Fiona C. Simpson
Christopher D. McTiernan
Mohammad Mirazul Islam
Oleksiy Buznyk
Philip N. Lewis
Keith M. Meek
Michel Haagdorens
Cindy Audiger
Sylvie Lesage
François-Xavier Gueriot
Isabelle Brunette
Marie-Claude Robert
David Olsen
Laura Koivusalo
Aneta Liszka
Per Fagerholm
Miguel Gonzalez-Andrades
May Griffith
Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs
description Simpson, McTiernan et al. develop fully synthetic corneal implants. The resulting CLP-PEG-MPC implants show reduced corneal swelling, haze, and neovascularization compared to CLP-PEG only implants when grafted into a mini-pig cornea alkali burn model of inflammation over 12 months. This study suggests the superiority of CLP-PEG-MPC implants over the CLP-PEG only implants.
format article
author Fiona C. Simpson
Christopher D. McTiernan
Mohammad Mirazul Islam
Oleksiy Buznyk
Philip N. Lewis
Keith M. Meek
Michel Haagdorens
Cindy Audiger
Sylvie Lesage
François-Xavier Gueriot
Isabelle Brunette
Marie-Claude Robert
David Olsen
Laura Koivusalo
Aneta Liszka
Per Fagerholm
Miguel Gonzalez-Andrades
May Griffith
author_facet Fiona C. Simpson
Christopher D. McTiernan
Mohammad Mirazul Islam
Oleksiy Buznyk
Philip N. Lewis
Keith M. Meek
Michel Haagdorens
Cindy Audiger
Sylvie Lesage
François-Xavier Gueriot
Isabelle Brunette
Marie-Claude Robert
David Olsen
Laura Koivusalo
Aneta Liszka
Per Fagerholm
Miguel Gonzalez-Andrades
May Griffith
author_sort Fiona C. Simpson
title Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs
title_short Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs
title_full Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs
title_fullStr Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs
title_full_unstemmed Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs
title_sort collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/da52745a8e174b3fb69db4effa395084
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