GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons

The molecular mechanism controlling the trafficking and function of AMPARs at synapses are not fully understood. Here the authors show that GSG1L, a membrane protein, negatively regulates AMPAR-mediated synaptic transmission and represents a new class of AMPAR auxiliary subunit.

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Autores principales:	Xinglong Gu, Xia Mao, Marc P. Lussier, Mary Anne Hutchison, Liang Zhou, F. Kent Hamra, Katherine W. Roche, Wei Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/da577629600d4e19af92086f063fbc57
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spelling	oai:doaj.org-article:da577629600d4e19af92086f063fbc572021-12-02T15:34:11ZGSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons10.1038/ncomms108732041-1723https://doaj.org/article/da577629600d4e19af92086f063fbc572016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10873https://doaj.org/toc/2041-1723The molecular mechanism controlling the trafficking and function of AMPARs at synapses are not fully understood. Here the authors show that GSG1L, a membrane protein, negatively regulates AMPAR-mediated synaptic transmission and represents a new class of AMPAR auxiliary subunit.Xinglong GuXia MaoMarc P. LussierMary Anne HutchisonLiang ZhouF. Kent HamraKatherine W. RocheWei LuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xinglong Gu Xia Mao Marc P. Lussier Mary Anne Hutchison Liang Zhou F. Kent Hamra Katherine W. Roche Wei Lu GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons
description	The molecular mechanism controlling the trafficking and function of AMPARs at synapses are not fully understood. Here the authors show that GSG1L, a membrane protein, negatively regulates AMPAR-mediated synaptic transmission and represents a new class of AMPAR auxiliary subunit.
format	article
author	Xinglong Gu Xia Mao Marc P. Lussier Mary Anne Hutchison Liang Zhou F. Kent Hamra Katherine W. Roche Wei Lu
author_facet	Xinglong Gu Xia Mao Marc P. Lussier Mary Anne Hutchison Liang Zhou F. Kent Hamra Katherine W. Roche Wei Lu
author_sort	Xinglong Gu
title	GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons
title_short	GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons
title_full	GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons
title_fullStr	GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons
title_full_unstemmed	GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons
title_sort	gsg1l suppresses ampa receptor-mediated synaptic transmission and uniquely modulates ampa receptor kinetics in hippocampal neurons
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/da577629600d4e19af92086f063fbc57
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GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons

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