Deficit in hippocampal ripples does not preclude spatial memory formation in APP/PS1 mice

Abstract General theory of declarative memory formation posits a cortical-hippocampal dialog during which hippocampal ripple oscillations support information transfer and long-term consolidation of hippocampus dependent memories. Brain dementia, as Alzheimer disease (AD), is accompanied by memory lo...

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Autores principales:	Bartosz Jura, Nathalie Macrez, Pierre Meyrand, Tiaza Bem
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/da591211962046feba59a0edfdcc8caf
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spelling	oai:doaj.org-article:da591211962046feba59a0edfdcc8caf2021-12-02T13:35:03ZDeficit in hippocampal ripples does not preclude spatial memory formation in APP/PS1 mice10.1038/s41598-019-56582-w2045-2322https://doaj.org/article/da591211962046feba59a0edfdcc8caf2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-56582-whttps://doaj.org/toc/2045-2322Abstract General theory of declarative memory formation posits a cortical-hippocampal dialog during which hippocampal ripple oscillations support information transfer and long-term consolidation of hippocampus dependent memories. Brain dementia, as Alzheimer disease (AD), is accompanied by memory loss and inability to form new memories. A large body of work has shown variety of mechanisms acting at cellular and molecular levels which can putatively play an important role in the impairment of memory formation. However, far less is known about changes occurring at the network-level activity patterns that support memory processing. Using freely moving APP/PS1 mice, a model of AD, we undertook a study to unravel the alterations of the activity of hippocampal and cortical circuits during generation of ripples in the transgenic and wild-type mice undergoing encoding and consolidation of spatial information. We report that APP/PS1 animals are able to consolidate spatial memory despite a major deficit of hippocampal ripples occurrence rate and learning dependent dynamics. We propose that these impairments may be compensated by an increase of the occurrence of cortical ripples and reorganization of cortical-hippocampal interaction.Bartosz JuraNathalie MacrezPierre MeyrandTiaza BemNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bartosz Jura Nathalie Macrez Pierre Meyrand Tiaza Bem Deficit in hippocampal ripples does not preclude spatial memory formation in APP/PS1 mice
description	Abstract General theory of declarative memory formation posits a cortical-hippocampal dialog during which hippocampal ripple oscillations support information transfer and long-term consolidation of hippocampus dependent memories. Brain dementia, as Alzheimer disease (AD), is accompanied by memory loss and inability to form new memories. A large body of work has shown variety of mechanisms acting at cellular and molecular levels which can putatively play an important role in the impairment of memory formation. However, far less is known about changes occurring at the network-level activity patterns that support memory processing. Using freely moving APP/PS1 mice, a model of AD, we undertook a study to unravel the alterations of the activity of hippocampal and cortical circuits during generation of ripples in the transgenic and wild-type mice undergoing encoding and consolidation of spatial information. We report that APP/PS1 animals are able to consolidate spatial memory despite a major deficit of hippocampal ripples occurrence rate and learning dependent dynamics. We propose that these impairments may be compensated by an increase of the occurrence of cortical ripples and reorganization of cortical-hippocampal interaction.
format	article
author	Bartosz Jura Nathalie Macrez Pierre Meyrand Tiaza Bem
author_facet	Bartosz Jura Nathalie Macrez Pierre Meyrand Tiaza Bem
author_sort	Bartosz Jura
title	Deficit in hippocampal ripples does not preclude spatial memory formation in APP/PS1 mice
title_short	Deficit in hippocampal ripples does not preclude spatial memory formation in APP/PS1 mice
title_full	Deficit in hippocampal ripples does not preclude spatial memory formation in APP/PS1 mice
title_fullStr	Deficit in hippocampal ripples does not preclude spatial memory formation in APP/PS1 mice
title_full_unstemmed	Deficit in hippocampal ripples does not preclude spatial memory formation in APP/PS1 mice
title_sort	deficit in hippocampal ripples does not preclude spatial memory formation in app/ps1 mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/da591211962046feba59a0edfdcc8caf
work_keys_str_mv	AT bartoszjura deficitinhippocampalripplesdoesnotprecludespatialmemoryformationinappps1mice AT nathaliemacrez deficitinhippocampalripplesdoesnotprecludespatialmemoryformationinappps1mice AT pierremeyrand deficitinhippocampalripplesdoesnotprecludespatialmemoryformationinappps1mice AT tiazabem deficitinhippocampalripplesdoesnotprecludespatialmemoryformationinappps1mice
_version_	1718392704803536896

Deficit in hippocampal ripples does not preclude spatial memory formation in APP/PS1 mice

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