Nationwide Glaucoma incidence in end stage renal disease patients and kidney transplant recipients

Abstract Glaucoma shares common risk factors with chronic kidney disease (CKD) but previous cross-sectional studies have demonstrated discrepancies in the risk of glaucoma in CKD patients. This study enrolled kidney transplantation recipients (KTRs) (n = 10,955), end stage renal disease (ESRD) patie...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jong Joo Moon, Yong Woo Kim, Baek-Lok Oh, Kyungdo Han, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Ki Ho Park, Hajeong Lee, Yong Chul Kim, Jin Wook Jeoung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/da5fa494abf148a683c6366097b30eda
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:da5fa494abf148a683c6366097b30eda
record_format	dspace
spelling	oai:doaj.org-article:da5fa494abf148a683c6366097b30eda2021-12-02T14:23:05ZNationwide Glaucoma incidence in end stage renal disease patients and kidney transplant recipients10.1038/s41598-021-86846-32045-2322https://doaj.org/article/da5fa494abf148a683c6366097b30eda2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86846-3https://doaj.org/toc/2045-2322Abstract Glaucoma shares common risk factors with chronic kidney disease (CKD) but previous cross-sectional studies have demonstrated discrepancies in the risk of glaucoma in CKD patients. This study enrolled kidney transplantation recipients (KTRs) (n = 10,955), end stage renal disease (ESRD) patients (n = 10,955) and healthy controls (n = 10,955) from National Health Insurance Service database of the Republic of Korea. A Cox proportional hazard regression model was used to calculate the hazard ratios (HR) for primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) incidences. The incidence of POAG was higher in ESRD patients (3.36/1,000 person-years, P < 0.0001) and KTRs (3.22 /1,000 person-years, P < 0.0001), than in healthy controls (1.20/1,000 person-years). However, POAG risk showed no significant increase in either ESRD patients (P = 0.07) or KTRs (P = 0.08) when adjusted for the confounding factors. The incidence of PACG was significantly higher in ESRD patients (0.41/1,000 person-years) than in healthy controls (0.14/1,000 person-years, P = 0.008). The PACG incidence was significantly lower in KTRs than in ESRD patients (HR = 0.35, P = 0.015). In conclusion, this nationwide cohort study demonstrated that kidney transplantation can reduce the risk of PACG but not POAG in ESRD patients.Jong Joo MoonYong Woo KimBaek-Lok OhKyungdo HanDong Ki KimKwon Wook JooYon Su KimKi Ho ParkHajeong LeeYong Chul KimJin Wook JeoungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jong Joo Moon Yong Woo Kim Baek-Lok Oh Kyungdo Han Dong Ki Kim Kwon Wook Joo Yon Su Kim Ki Ho Park Hajeong Lee Yong Chul Kim Jin Wook Jeoung Nationwide Glaucoma incidence in end stage renal disease patients and kidney transplant recipients
description	Abstract Glaucoma shares common risk factors with chronic kidney disease (CKD) but previous cross-sectional studies have demonstrated discrepancies in the risk of glaucoma in CKD patients. This study enrolled kidney transplantation recipients (KTRs) (n = 10,955), end stage renal disease (ESRD) patients (n = 10,955) and healthy controls (n = 10,955) from National Health Insurance Service database of the Republic of Korea. A Cox proportional hazard regression model was used to calculate the hazard ratios (HR) for primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) incidences. The incidence of POAG was higher in ESRD patients (3.36/1,000 person-years, P < 0.0001) and KTRs (3.22 /1,000 person-years, P < 0.0001), than in healthy controls (1.20/1,000 person-years). However, POAG risk showed no significant increase in either ESRD patients (P = 0.07) or KTRs (P = 0.08) when adjusted for the confounding factors. The incidence of PACG was significantly higher in ESRD patients (0.41/1,000 person-years) than in healthy controls (0.14/1,000 person-years, P = 0.008). The PACG incidence was significantly lower in KTRs than in ESRD patients (HR = 0.35, P = 0.015). In conclusion, this nationwide cohort study demonstrated that kidney transplantation can reduce the risk of PACG but not POAG in ESRD patients.
format	article
author	Jong Joo Moon Yong Woo Kim Baek-Lok Oh Kyungdo Han Dong Ki Kim Kwon Wook Joo Yon Su Kim Ki Ho Park Hajeong Lee Yong Chul Kim Jin Wook Jeoung
author_facet	Jong Joo Moon Yong Woo Kim Baek-Lok Oh Kyungdo Han Dong Ki Kim Kwon Wook Joo Yon Su Kim Ki Ho Park Hajeong Lee Yong Chul Kim Jin Wook Jeoung
author_sort	Jong Joo Moon
title	Nationwide Glaucoma incidence in end stage renal disease patients and kidney transplant recipients
title_short	Nationwide Glaucoma incidence in end stage renal disease patients and kidney transplant recipients
title_full	Nationwide Glaucoma incidence in end stage renal disease patients and kidney transplant recipients
title_fullStr	Nationwide Glaucoma incidence in end stage renal disease patients and kidney transplant recipients
title_full_unstemmed	Nationwide Glaucoma incidence in end stage renal disease patients and kidney transplant recipients
title_sort	nationwide glaucoma incidence in end stage renal disease patients and kidney transplant recipients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/da5fa494abf148a683c6366097b30eda
work_keys_str_mv	AT jongjoomoon nationwideglaucomaincidenceinendstagerenaldiseasepatientsandkidneytransplantrecipients AT yongwookim nationwideglaucomaincidenceinendstagerenaldiseasepatientsandkidneytransplantrecipients AT baeklokoh nationwideglaucomaincidenceinendstagerenaldiseasepatientsandkidneytransplantrecipients AT kyungdohan nationwideglaucomaincidenceinendstagerenaldiseasepatientsandkidneytransplantrecipients AT dongkikim nationwideglaucomaincidenceinendstagerenaldiseasepatientsandkidneytransplantrecipients AT kwonwookjoo nationwideglaucomaincidenceinendstagerenaldiseasepatientsandkidneytransplantrecipients AT yonsukim nationwideglaucomaincidenceinendstagerenaldiseasepatientsandkidneytransplantrecipients AT kihopark nationwideglaucomaincidenceinendstagerenaldiseasepatientsandkidneytransplantrecipients AT hajeonglee nationwideglaucomaincidenceinendstagerenaldiseasepatientsandkidneytransplantrecipients AT yongchulkim nationwideglaucomaincidenceinendstagerenaldiseasepatientsandkidneytransplantrecipients AT jinwookjeoung nationwideglaucomaincidenceinendstagerenaldiseasepatientsandkidneytransplantrecipients
_version_	1718391456522043392

Nationwide Glaucoma incidence in end stage renal disease patients and kidney transplant recipients

Ejemplares similares