Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity

Gut microbiome alterations have been linked to inflammatory bowel disease (IBD) and obesity. Here, the authors characterize the metagenomes of four large human cohorts and perform co-abundance network analysis showing that dysbiosis in disease is marked by the altered co-abundance relationships, sug...

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Autores principales:	Lianmin Chen, Valerie Collij, Martin Jaeger, Inge C. L. van den Munckhof, Arnau Vich Vila, Alexander Kurilshikov, Ranko Gacesa, Trishla Sinha, Marije Oosting, Leo A. B. Joosten, Joost H. W. Rutten, Niels P. Riksen, Ramnik J. Xavier, Folkert Kuipers, Cisca Wijmenga, Alexandra Zhernakova, Mihai G. Netea, Rinse K. Weersma, Jingyuan Fu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/da603f99168743a3ba6b2f114c36782d
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spelling	oai:doaj.org-article:da603f99168743a3ba6b2f114c36782d2021-12-02T15:08:41ZGut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity10.1038/s41467-020-17840-y2041-1723https://doaj.org/article/da603f99168743a3ba6b2f114c36782d2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17840-yhttps://doaj.org/toc/2041-1723Gut microbiome alterations have been linked to inflammatory bowel disease (IBD) and obesity. Here, the authors characterize the metagenomes of four large human cohorts and perform co-abundance network analysis showing that dysbiosis in disease is marked by the altered co-abundance relationships, suggesting that pathway coabundance networks are more heterogeneous than species network.Lianmin ChenValerie CollijMartin JaegerInge C. L. van den MunckhofArnau Vich VilaAlexander KurilshikovRanko GacesaTrishla SinhaMarije OostingLeo A. B. JoostenJoost H. W. RuttenNiels P. RiksenRamnik J. XavierFolkert KuipersCisca WijmengaAlexandra ZhernakovaMihai G. NeteaRinse K. WeersmaJingyuan FuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lianmin Chen Valerie Collij Martin Jaeger Inge C. L. van den Munckhof Arnau Vich Vila Alexander Kurilshikov Ranko Gacesa Trishla Sinha Marije Oosting Leo A. B. Joosten Joost H. W. Rutten Niels P. Riksen Ramnik J. Xavier Folkert Kuipers Cisca Wijmenga Alexandra Zhernakova Mihai G. Netea Rinse K. Weersma Jingyuan Fu Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity
description	Gut microbiome alterations have been linked to inflammatory bowel disease (IBD) and obesity. Here, the authors characterize the metagenomes of four large human cohorts and perform co-abundance network analysis showing that dysbiosis in disease is marked by the altered co-abundance relationships, suggesting that pathway coabundance networks are more heterogeneous than species network.
format	article
author	Lianmin Chen Valerie Collij Martin Jaeger Inge C. L. van den Munckhof Arnau Vich Vila Alexander Kurilshikov Ranko Gacesa Trishla Sinha Marije Oosting Leo A. B. Joosten Joost H. W. Rutten Niels P. Riksen Ramnik J. Xavier Folkert Kuipers Cisca Wijmenga Alexandra Zhernakova Mihai G. Netea Rinse K. Weersma Jingyuan Fu
author_facet	Lianmin Chen Valerie Collij Martin Jaeger Inge C. L. van den Munckhof Arnau Vich Vila Alexander Kurilshikov Ranko Gacesa Trishla Sinha Marije Oosting Leo A. B. Joosten Joost H. W. Rutten Niels P. Riksen Ramnik J. Xavier Folkert Kuipers Cisca Wijmenga Alexandra Zhernakova Mihai G. Netea Rinse K. Weersma Jingyuan Fu
author_sort	Lianmin Chen
title	Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity
title_short	Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity
title_full	Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity
title_fullStr	Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity
title_full_unstemmed	Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity
title_sort	gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/da603f99168743a3ba6b2f114c36782d
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Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity

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