Efficacy of combined treatment of distal polyneuropathy in patients with type 2 diabetes mellitus and concomitant primaryhypothyroidism

Aim. To study changes of metabolic parameters and neurologic manifestations in patients with type 2 diabetes mellitus and concomitant primaryhypothyroidism under effect of combined therapy. Materials and methods. 62 patients with distal neuropathy (DN) including 16 with DM2 and primary hypothyroid...

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Autores principales:	Inessa Ivanovna Dubinina, Tatiana Vladimirovna Karapysh, Nina Fedorovna Nosova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2011
Materias:	distal neuropathy type 2 diabetes primary hypothyroidism Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/da611e6ea4b34e2e9b3a1d92d63851a7
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spelling	oai:doaj.org-article:da611e6ea4b34e2e9b3a1d92d63851a72021-11-14T09:00:16ZEfficacy of combined treatment of distal polyneuropathy in patients with type 2 diabetes mellitus and concomitant primaryhypothyroidism2072-03512072-037810.14341/2072-0351-6228https://doaj.org/article/da611e6ea4b34e2e9b3a1d92d63851a72011-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6228https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To study changes of metabolic parameters and neurologic manifestations in patients with type 2 diabetes mellitus and concomitant primaryhypothyroidism under effect of combined therapy. Materials and methods. 62 patients with distal neuropathy (DN) including 16 with DM2 and primary hypothyroidism (PHT) (group 1), 32 DM2patients without thyroid pathology (group 2), and 15 patients with PHT without DM (group 3). The patients were matched for age and durationof all above diseases. They were treated by alpha lipoic acid-based drugs: thioctacid, thiogamma, berlithion, octolipen (600 U/d i/v), vitamins B:milgamma, combilipen (2 ml/d i/m) for 12 weeks. All measurements were made at admittance, 21 days and 12 weeks after it. The efficacy of therapywas estimated from changes in HbA1c levels, fasting and postprandial glycemia, lipid metabolism. DN was diagnosed using NSS, TSS, NDS, NDSm,and NIS-LL scales. Results. Combined therapy of patients with DM2 and PHT resulted in a decrease of HbA1c levels within 12 weeks, fasting and postprandialglycemia within 21 and 12 weeks respectively. Compensation of PHT led to a decrease of total cholesterol and triglyceride levels within 12 weeks.Subcompensation of carbohydrate metabolism (postprandial glycemia) improved neurologic symptoms within 21 weeks in all patients (NSS and TSSscales). The same effect was documented within 12 weeks in patients without thyroid pathology (NSS, TSS, NDS, NDSm, and NIS-LL scales). Inthose with PHT beneficial effect was revealed only using the NIS-LL scale. The worst outcome of therapy estimated from NSS, TSS, NDS, NDSm,and NIS-LL scales was documented in patients with DM2+PHT probably due to additional effect of thyroid pathology on the severity of DN. Conclusion. The use of NSS, TSS, NDS, NDSm, and NIS-LL scales makes it possible to reveal changes in the severity of sensorimotor disturbancesin DN patients depending on metabolic parameters modified by pathogenetic therapy.Inessa Ivanovna DubininaTatiana Vladimirovna KarapyshNina Fedorovna NosovaEndocrinology Research Centrearticledistal neuropathytype 2 diabetesprimary hypothyroidismNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 14, Iss 3, Pp 76-79 (2011)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	distal neuropathy type 2 diabetes primary hypothyroidism Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	distal neuropathy type 2 diabetes primary hypothyroidism Nutritional diseases. Deficiency diseases RC620-627 Inessa Ivanovna Dubinina Tatiana Vladimirovna Karapysh Nina Fedorovna Nosova Efficacy of combined treatment of distal polyneuropathy in patients with type 2 diabetes mellitus and concomitant primaryhypothyroidism
description	Aim. To study changes of metabolic parameters and neurologic manifestations in patients with type 2 diabetes mellitus and concomitant primaryhypothyroidism under effect of combined therapy. Materials and methods. 62 patients with distal neuropathy (DN) including 16 with DM2 and primary hypothyroidism (PHT) (group 1), 32 DM2patients without thyroid pathology (group 2), and 15 patients with PHT without DM (group 3). The patients were matched for age and durationof all above diseases. They were treated by alpha lipoic acid-based drugs: thioctacid, thiogamma, berlithion, octolipen (600 U/d i/v), vitamins B:milgamma, combilipen (2 ml/d i/m) for 12 weeks. All measurements were made at admittance, 21 days and 12 weeks after it. The efficacy of therapywas estimated from changes in HbA1c levels, fasting and postprandial glycemia, lipid metabolism. DN was diagnosed using NSS, TSS, NDS, NDSm,and NIS-LL scales. Results. Combined therapy of patients with DM2 and PHT resulted in a decrease of HbA1c levels within 12 weeks, fasting and postprandialglycemia within 21 and 12 weeks respectively. Compensation of PHT led to a decrease of total cholesterol and triglyceride levels within 12 weeks.Subcompensation of carbohydrate metabolism (postprandial glycemia) improved neurologic symptoms within 21 weeks in all patients (NSS and TSSscales). The same effect was documented within 12 weeks in patients without thyroid pathology (NSS, TSS, NDS, NDSm, and NIS-LL scales). Inthose with PHT beneficial effect was revealed only using the NIS-LL scale. The worst outcome of therapy estimated from NSS, TSS, NDS, NDSm,and NIS-LL scales was documented in patients with DM2+PHT probably due to additional effect of thyroid pathology on the severity of DN. Conclusion. The use of NSS, TSS, NDS, NDSm, and NIS-LL scales makes it possible to reveal changes in the severity of sensorimotor disturbancesin DN patients depending on metabolic parameters modified by pathogenetic therapy.
format	article
author	Inessa Ivanovna Dubinina Tatiana Vladimirovna Karapysh Nina Fedorovna Nosova
author_facet	Inessa Ivanovna Dubinina Tatiana Vladimirovna Karapysh Nina Fedorovna Nosova
author_sort	Inessa Ivanovna Dubinina
title	Efficacy of combined treatment of distal polyneuropathy in patients with type 2 diabetes mellitus and concomitant primaryhypothyroidism
title_short	Efficacy of combined treatment of distal polyneuropathy in patients with type 2 diabetes mellitus and concomitant primaryhypothyroidism
title_full	Efficacy of combined treatment of distal polyneuropathy in patients with type 2 diabetes mellitus and concomitant primaryhypothyroidism
title_fullStr	Efficacy of combined treatment of distal polyneuropathy in patients with type 2 diabetes mellitus and concomitant primaryhypothyroidism
title_full_unstemmed	Efficacy of combined treatment of distal polyneuropathy in patients with type 2 diabetes mellitus and concomitant primaryhypothyroidism
title_sort	efficacy of combined treatment of distal polyneuropathy in patients with type 2 diabetes mellitus and concomitant primaryhypothyroidism
publisher	Endocrinology Research Centre
publishDate	2011
url	https://doaj.org/article/da611e6ea4b34e2e9b3a1d92d63851a7
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Efficacy of combined treatment of distal polyneuropathy in patients with type 2 diabetes mellitus and concomitant primaryhypothyroidism

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