Host Sex Steroids Interact With Virus Infection: New Insights Into Sex Disparity in Infectious Diseases

Sex hormones are steroid hormones synthesized from the gonads of animals and tissues such as the placenta and adrenocortical reticular zone. The physiological functions of sex hormones are complex. Sex hormones are not only pathologically correlated with many diseases of the reproductive system, but...

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Autores principales:	Jinfeng Wu, Lei Zhang, Xing Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	human viruses virus infection male predominance androgen receptor transmembrane protease/serine subfamily member 2 Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/da627c099ee64a15b2a2187bbe8d7cd0
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spelling	oai:doaj.org-article:da627c099ee64a15b2a2187bbe8d7cd02021-11-04T09:15:26ZHost Sex Steroids Interact With Virus Infection: New Insights Into Sex Disparity in Infectious Diseases1664-302X10.3389/fmicb.2021.747347https://doaj.org/article/da627c099ee64a15b2a2187bbe8d7cd02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.747347/fullhttps://doaj.org/toc/1664-302XSex hormones are steroid hormones synthesized from the gonads of animals and tissues such as the placenta and adrenocortical reticular zone. The physiological functions of sex hormones are complex. Sex hormones are not only pathologically correlated with many diseases of the reproductive system, but are etiological factors in some viral infectious diseases, including disease caused by infections of coronaviruses, herpesviruses, hepatitis viruses, and other kinds of human viruses, which either exhibit a male propensity in clinical practice, or crosstalk with androgen receptor (AR)-related pathways in viral pathogenesis. Due to the global pandemic of coronavirus disease 2019 (COVID-19), the role of androgen/AR in viral infectious disease is highlighted again, majorly representing by the recent advances of AR-responsive gene of transmembrane protease/serine subfamily member 2 (TMPRSS2), which proteolytically activates the receptor-mediated virus entry by many coronaviruses and influenza virus, along with the role of androgen-mediated signaling for the transcription of hepatitis B virus (HBV), and the role of sex hormone responsive genes during Zika virus (ZIKV) pathogenesis, et al. Collectively, we propose to provide a comprehensive overview of the role of male sex hormones during multiple phases in the life cycle of different human viruses, which may be partly responsible for the sex-specific prevalence, severity and mortality of some diseases, therefore, may provide clues to develop more efficient prevention and treatment strategies for high-risk populations.Jinfeng WuLei ZhangXing WangFrontiers Media S.A.articlehuman virusesvirus infectionmale predominanceandrogen receptortransmembrane protease/serine subfamily member 2MicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	human viruses virus infection male predominance androgen receptor transmembrane protease/serine subfamily member 2 Microbiology QR1-502
spellingShingle	human viruses virus infection male predominance androgen receptor transmembrane protease/serine subfamily member 2 Microbiology QR1-502 Jinfeng Wu Lei Zhang Xing Wang Host Sex Steroids Interact With Virus Infection: New Insights Into Sex Disparity in Infectious Diseases
description	Sex hormones are steroid hormones synthesized from the gonads of animals and tissues such as the placenta and adrenocortical reticular zone. The physiological functions of sex hormones are complex. Sex hormones are not only pathologically correlated with many diseases of the reproductive system, but are etiological factors in some viral infectious diseases, including disease caused by infections of coronaviruses, herpesviruses, hepatitis viruses, and other kinds of human viruses, which either exhibit a male propensity in clinical practice, or crosstalk with androgen receptor (AR)-related pathways in viral pathogenesis. Due to the global pandemic of coronavirus disease 2019 (COVID-19), the role of androgen/AR in viral infectious disease is highlighted again, majorly representing by the recent advances of AR-responsive gene of transmembrane protease/serine subfamily member 2 (TMPRSS2), which proteolytically activates the receptor-mediated virus entry by many coronaviruses and influenza virus, along with the role of androgen-mediated signaling for the transcription of hepatitis B virus (HBV), and the role of sex hormone responsive genes during Zika virus (ZIKV) pathogenesis, et al. Collectively, we propose to provide a comprehensive overview of the role of male sex hormones during multiple phases in the life cycle of different human viruses, which may be partly responsible for the sex-specific prevalence, severity and mortality of some diseases, therefore, may provide clues to develop more efficient prevention and treatment strategies for high-risk populations.
format	article
author	Jinfeng Wu Lei Zhang Xing Wang
author_facet	Jinfeng Wu Lei Zhang Xing Wang
author_sort	Jinfeng Wu
title	Host Sex Steroids Interact With Virus Infection: New Insights Into Sex Disparity in Infectious Diseases
title_short	Host Sex Steroids Interact With Virus Infection: New Insights Into Sex Disparity in Infectious Diseases
title_full	Host Sex Steroids Interact With Virus Infection: New Insights Into Sex Disparity in Infectious Diseases
title_fullStr	Host Sex Steroids Interact With Virus Infection: New Insights Into Sex Disparity in Infectious Diseases
title_full_unstemmed	Host Sex Steroids Interact With Virus Infection: New Insights Into Sex Disparity in Infectious Diseases
title_sort	host sex steroids interact with virus infection: new insights into sex disparity in infectious diseases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/da627c099ee64a15b2a2187bbe8d7cd0
work_keys_str_mv	AT jinfengwu hostsexsteroidsinteractwithvirusinfectionnewinsightsintosexdisparityininfectiousdiseases AT leizhang hostsexsteroidsinteractwithvirusinfectionnewinsightsintosexdisparityininfectiousdiseases AT xingwang hostsexsteroidsinteractwithvirusinfectionnewinsightsintosexdisparityininfectiousdiseases
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Host Sex Steroids Interact With Virus Infection: New Insights Into Sex Disparity in Infectious Diseases

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