Endothelial progenitor cells in diabetes complications

Patients with diabetes mellitus (DM) have a 2- to 4-times higher risk of developing cardiovascular complications compared with non-diabetic controls. Hyperglycemia activates pathophysiological mechanisms that damage the endothelium. According to the current views, circulating progenitor cells derive...

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Autores principales:	Marina Cergeevna Michurova, Victor Yur'evich Kalashnikov, Olga Michailovna Smirnova, Irina Vladimirovna Kononenko, Olga Nikolaevna Ivanova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2015
Materias:	diabetes mellitus endothelial progenitor cells diabetic complications cardiovascular disease Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/da6566d9df30417895429f3bcbceb1e0
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spelling	oai:doaj.org-article:da6566d9df30417895429f3bcbceb1e02021-11-14T09:00:19ZEndothelial progenitor cells in diabetes complications2072-03512072-037810.14341/DM2015124-32https://doaj.org/article/da6566d9df30417895429f3bcbceb1e02015-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6771https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Patients with diabetes mellitus (DM) have a 2- to 4-times higher risk of developing cardiovascular complications compared with non-diabetic controls. Hyperglycemia activates pathophysiological mechanisms that damage the endothelium. According to the current views, circulating progenitor cells derived from bone marrow repair the damage. These cells, known as endothelial progenitor cells (EPCs), maintain endothelial homeostasis and contribute to the formation of new vessels. Many clinical studies have reported that EPC population is dysfunctional and declines in numbers in patients with type 1 and type 2 DM. In addition, bone marrow doesn?t respond adequately to mobilizing stimuli in DM. Therefore, EPC alterations might have a pathogenic role in the complications of DM. In this review, EPC alterations will be examined in the context of macrovascular and microvascular complications of DM, highlighting their roles and functions in the progression of the disease.Marina Cergeevna MichurovaVictor Yur'evich KalashnikovOlga Michailovna SmirnovaIrina Vladimirovna KononenkoOlga Nikolaevna IvanovaEndocrinology Research Centrearticlediabetes mellitusendothelial progenitor cellsdiabetic complicationscardiovascular diseaseNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 1, Pp 24-32 (2015)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus endothelial progenitor cells diabetic complications cardiovascular disease Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus endothelial progenitor cells diabetic complications cardiovascular disease Nutritional diseases. Deficiency diseases RC620-627 Marina Cergeevna Michurova Victor Yur'evich Kalashnikov Olga Michailovna Smirnova Irina Vladimirovna Kononenko Olga Nikolaevna Ivanova Endothelial progenitor cells in diabetes complications
description	Patients with diabetes mellitus (DM) have a 2- to 4-times higher risk of developing cardiovascular complications compared with non-diabetic controls. Hyperglycemia activates pathophysiological mechanisms that damage the endothelium. According to the current views, circulating progenitor cells derived from bone marrow repair the damage. These cells, known as endothelial progenitor cells (EPCs), maintain endothelial homeostasis and contribute to the formation of new vessels. Many clinical studies have reported that EPC population is dysfunctional and declines in numbers in patients with type 1 and type 2 DM. In addition, bone marrow doesn?t respond adequately to mobilizing stimuli in DM. Therefore, EPC alterations might have a pathogenic role in the complications of DM. In this review, EPC alterations will be examined in the context of macrovascular and microvascular complications of DM, highlighting their roles and functions in the progression of the disease.
format	article
author	Marina Cergeevna Michurova Victor Yur'evich Kalashnikov Olga Michailovna Smirnova Irina Vladimirovna Kononenko Olga Nikolaevna Ivanova
author_facet	Marina Cergeevna Michurova Victor Yur'evich Kalashnikov Olga Michailovna Smirnova Irina Vladimirovna Kononenko Olga Nikolaevna Ivanova
author_sort	Marina Cergeevna Michurova
title	Endothelial progenitor cells in diabetes complications
title_short	Endothelial progenitor cells in diabetes complications
title_full	Endothelial progenitor cells in diabetes complications
title_fullStr	Endothelial progenitor cells in diabetes complications
title_full_unstemmed	Endothelial progenitor cells in diabetes complications
title_sort	endothelial progenitor cells in diabetes complications
publisher	Endocrinology Research Centre
publishDate	2015
url	https://doaj.org/article/da6566d9df30417895429f3bcbceb1e0
work_keys_str_mv	AT marinacergeevnamichurova endothelialprogenitorcellsindiabetescomplications AT victoryurevichkalashnikov endothelialprogenitorcellsindiabetescomplications AT olgamichailovnasmirnova endothelialprogenitorcellsindiabetescomplications AT irinavladimirovnakononenko endothelialprogenitorcellsindiabetescomplications AT olganikolaevnaivanova endothelialprogenitorcellsindiabetescomplications
_version_	1718429558850453504

Endothelial progenitor cells in diabetes complications

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