ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homeostasis of the tumour microenvironment. Here the authors show that all-trans retinoic acid reduces retinoic acid receptor beta dependent-actomyosin contractility and restores mechanical quiescence in PSCs.

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Autores principales:	Antonios Chronopoulos, Benjamin Robinson, Muge Sarper, Ernesto Cortes, Vera Auernheimer, Dariusz Lachowski, Simon Attwood, Rebeca García, Saba Ghassemi, Ben Fabry, Armando del Río Hernández
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/da659059009b42a39f200eed69fb8d38
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spelling	oai:doaj.org-article:da659059009b42a39f200eed69fb8d382021-12-02T14:39:12ZATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion10.1038/ncomms126302041-1723https://doaj.org/article/da659059009b42a39f200eed69fb8d382016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12630https://doaj.org/toc/2041-1723Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homeostasis of the tumour microenvironment. Here the authors show that all-trans retinoic acid reduces retinoic acid receptor beta dependent-actomyosin contractility and restores mechanical quiescence in PSCs.Antonios ChronopoulosBenjamin RobinsonMuge SarperErnesto CortesVera AuernheimerDariusz LachowskiSimon AttwoodRebeca GarcíaSaba GhassemiBen FabryArmando del Río HernándezNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Antonios Chronopoulos Benjamin Robinson Muge Sarper Ernesto Cortes Vera Auernheimer Dariusz Lachowski Simon Attwood Rebeca García Saba Ghassemi Ben Fabry Armando del Río Hernández ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
description	Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homeostasis of the tumour microenvironment. Here the authors show that all-trans retinoic acid reduces retinoic acid receptor beta dependent-actomyosin contractility and restores mechanical quiescence in PSCs.
format	article
author	Antonios Chronopoulos Benjamin Robinson Muge Sarper Ernesto Cortes Vera Auernheimer Dariusz Lachowski Simon Attwood Rebeca García Saba Ghassemi Ben Fabry Armando del Río Hernández
author_facet	Antonios Chronopoulos Benjamin Robinson Muge Sarper Ernesto Cortes Vera Auernheimer Dariusz Lachowski Simon Attwood Rebeca García Saba Ghassemi Ben Fabry Armando del Río Hernández
author_sort	Antonios Chronopoulos
title	ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
title_short	ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
title_full	ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
title_fullStr	ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
title_full_unstemmed	ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
title_sort	atra mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/da659059009b42a39f200eed69fb8d38
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ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

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