Variation of BMP3 contributes to dog breed skull diversity.
Since the beginnings of domestication, the craniofacial architecture of the domestic dog has morphed and radiated to human whims. By beginning to define the genetic underpinnings of breed skull shapes, we can elucidate mechanisms of morphological diversification while presenting a framework for unde...
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Public Library of Science (PLoS)
2012
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oai:doaj.org-article:da65ca9d6a76427a9ce911d89d9ba5ca2021-11-18T06:18:17ZVariation of BMP3 contributes to dog breed skull diversity.1553-73901553-740410.1371/journal.pgen.1002849https://doaj.org/article/da65ca9d6a76427a9ce911d89d9ba5ca2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22876193/pdf/?tool=EBIhttps://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404Since the beginnings of domestication, the craniofacial architecture of the domestic dog has morphed and radiated to human whims. By beginning to define the genetic underpinnings of breed skull shapes, we can elucidate mechanisms of morphological diversification while presenting a framework for understanding human cephalic disorders. Using intrabreed association mapping with museum specimen measurements, we show that skull shape is regulated by at least five quantitative trait loci (QTLs). Our detailed analysis using whole-genome sequencing uncovers a missense mutation in BMP3. Validation studies in zebrafish show that Bmp3 function in cranial development is ancient. Our study reveals the causal variant for a canine QTL contributing to a major morphologic trait.Jeffrey J SchoenebeckSarah A HutchinsonAlexandra ByersHolly C BealeBlake CarringtonDaniel L FadenMaud RimbaultBrennan DeckerJeffrey M KiddRaman SoodAdam R BoykoJohn W FondonRobert K WayneCarlos D BustamanteBrian CirunaElaine A OstranderPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 8, Iss 8, p e1002849 (2012) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Genetics QH426-470 |
| spellingShingle |
Genetics QH426-470 Jeffrey J Schoenebeck Sarah A Hutchinson Alexandra Byers Holly C Beale Blake Carrington Daniel L Faden Maud Rimbault Brennan Decker Jeffrey M Kidd Raman Sood Adam R Boyko John W Fondon Robert K Wayne Carlos D Bustamante Brian Ciruna Elaine A Ostrander Variation of BMP3 contributes to dog breed skull diversity. |
| description |
Since the beginnings of domestication, the craniofacial architecture of the domestic dog has morphed and radiated to human whims. By beginning to define the genetic underpinnings of breed skull shapes, we can elucidate mechanisms of morphological diversification while presenting a framework for understanding human cephalic disorders. Using intrabreed association mapping with museum specimen measurements, we show that skull shape is regulated by at least five quantitative trait loci (QTLs). Our detailed analysis using whole-genome sequencing uncovers a missense mutation in BMP3. Validation studies in zebrafish show that Bmp3 function in cranial development is ancient. Our study reveals the causal variant for a canine QTL contributing to a major morphologic trait. |
| format |
article |
| author |
Jeffrey J Schoenebeck Sarah A Hutchinson Alexandra Byers Holly C Beale Blake Carrington Daniel L Faden Maud Rimbault Brennan Decker Jeffrey M Kidd Raman Sood Adam R Boyko John W Fondon Robert K Wayne Carlos D Bustamante Brian Ciruna Elaine A Ostrander |
| author_facet |
Jeffrey J Schoenebeck Sarah A Hutchinson Alexandra Byers Holly C Beale Blake Carrington Daniel L Faden Maud Rimbault Brennan Decker Jeffrey M Kidd Raman Sood Adam R Boyko John W Fondon Robert K Wayne Carlos D Bustamante Brian Ciruna Elaine A Ostrander |
| author_sort |
Jeffrey J Schoenebeck |
| title |
Variation of BMP3 contributes to dog breed skull diversity. |
| title_short |
Variation of BMP3 contributes to dog breed skull diversity. |
| title_full |
Variation of BMP3 contributes to dog breed skull diversity. |
| title_fullStr |
Variation of BMP3 contributes to dog breed skull diversity. |
| title_full_unstemmed |
Variation of BMP3 contributes to dog breed skull diversity. |
| title_sort |
variation of bmp3 contributes to dog breed skull diversity. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/da65ca9d6a76427a9ce911d89d9ba5ca |
| work_keys_str_mv |
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| _version_ |
1718424509812310016 |