Bismuth oxide aqueous colloidal nanoparticles inhibit Candida albicans growth and biofilm formation

Rene Hernandez-Delgadillo,1 Donaji Velasco-Arias,3 Juan Jose Martinez-Sanmiguel,2 David Diaz,3 Inti Zumeta-Dube,3 Katiushka Arevalo-Niño,1 Claudio Cabral-Romero2 1Facultad de Ciencias Biológicas, Instituto de Biotecnologia, Universidad Autonoma de Nuevo Leon, UANL, Monterrey, M...

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Autores principales:	Hernandez-Delgadillo R, Velasco-Arias D, Martinez-Sanmiguel JJ, Diaz D, Zumeta-Dube I, Arevalo-Ni&ntilde;o K, Cabral-Romero C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/da666ecfce884f8d9c038d25880831f2
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spelling	oai:doaj.org-article:da666ecfce884f8d9c038d25880831f22021-12-02T02:10:26ZBismuth oxide aqueous colloidal nanoparticles inhibit Candida albicans growth and biofilm formation1176-91141178-2013https://doaj.org/article/da666ecfce884f8d9c038d25880831f22013-04-01T00:00:00Zhttp://www.dovepress.com/bismuth-oxide-aqueous-colloidal-nanoparticles-inhibit-candida-albicans-a12863https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Rene Hernandez-Delgadillo,1 Donaji Velasco-Arias,3 Juan Jose Martinez-Sanmiguel,2 David Diaz,3 Inti Zumeta-Dube,3 Katiushka Arevalo-Niño,1 Claudio Cabral-Romero2 1Facultad de Ciencias Biológicas, Instituto de Biotecnologia, Universidad Autonoma de Nuevo Leon, UANL, Monterrey, Mexico; 2Facultad de Odontología, Universidad Autonoma de Nuevo Leon, UANL, Monterrey, México; 3Facultad de Quimica, Universidad Nacional Autonoma de Mexico, UNAM, Distrito Federal, México Abstract: Multiresistance among microorganisms to common antimicrobials has become one of the most significant concerns in modern medicine. Nanomaterials are a new alternative to successfully treat the multiresistant microorganisms. Nanostructured materials are used in many fields, including biological sciences and medicine. Recently, it was demonstrated that the bactericidal activity of zero-valent bismuth colloidal nanoparticles inhibited the growth of Streptococcus mutans; however the antimycotic potential of bismuth nanostructured derivatives has not yet been studied. The main objective of this investigation was to analyze the fungicidal activity of bismuth oxide nanoparticles against Candida albicans, and their antibiofilm capabilities. Our results showed that aqueous colloidal bismuth oxide nanoparticles displayed antimicrobial activity against C. albicans growth (reducing colony size by 85%) and a complete inhibition of biofilm formation. These results are better than those obtained with chlorhexidine, nystatin, and terbinafine, the most effective oral antiseptic and commercial antifungal agents. In this work, we also compared the antimycotic activities of bulk bismuth oxide and bismuth nitrate, the precursor metallic salt. These results suggest that bismuth oxide colloidal nanoparticles could be a very interesting candidate as a fungicidal agent to be incorporated into an oral antiseptic. Additionally, we determined the minimum inhibitory concentration for the synthesized aqueous colloidal Bi2O3 nanoparticles. Keywords: antimycotic agent, antifungal, cytotoxicityHernandez-Delgadillo RVelasco-Arias DMartinez-Sanmiguel JJDiaz DZumeta-Dube IArevalo-Ni&ntilde;o KCabral-Romero CDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 1645-1652 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Hernandez-Delgadillo R Velasco-Arias D Martinez-Sanmiguel JJ Diaz D Zumeta-Dube I Arevalo-Ni&ntilde;o K Cabral-Romero C Bismuth oxide aqueous colloidal nanoparticles inhibit Candida albicans growth and biofilm formation
description	Rene Hernandez-Delgadillo,1 Donaji Velasco-Arias,3 Juan Jose Martinez-Sanmiguel,2 David Diaz,3 Inti Zumeta-Dube,3 Katiushka Arevalo-Niño,1 Claudio Cabral-Romero2 1Facultad de Ciencias Biológicas, Instituto de Biotecnologia, Universidad Autonoma de Nuevo Leon, UANL, Monterrey, Mexico; 2Facultad de Odontología, Universidad Autonoma de Nuevo Leon, UANL, Monterrey, México; 3Facultad de Quimica, Universidad Nacional Autonoma de Mexico, UNAM, Distrito Federal, México Abstract: Multiresistance among microorganisms to common antimicrobials has become one of the most significant concerns in modern medicine. Nanomaterials are a new alternative to successfully treat the multiresistant microorganisms. Nanostructured materials are used in many fields, including biological sciences and medicine. Recently, it was demonstrated that the bactericidal activity of zero-valent bismuth colloidal nanoparticles inhibited the growth of Streptococcus mutans; however the antimycotic potential of bismuth nanostructured derivatives has not yet been studied. The main objective of this investigation was to analyze the fungicidal activity of bismuth oxide nanoparticles against Candida albicans, and their antibiofilm capabilities. Our results showed that aqueous colloidal bismuth oxide nanoparticles displayed antimicrobial activity against C. albicans growth (reducing colony size by 85%) and a complete inhibition of biofilm formation. These results are better than those obtained with chlorhexidine, nystatin, and terbinafine, the most effective oral antiseptic and commercial antifungal agents. In this work, we also compared the antimycotic activities of bulk bismuth oxide and bismuth nitrate, the precursor metallic salt. These results suggest that bismuth oxide colloidal nanoparticles could be a very interesting candidate as a fungicidal agent to be incorporated into an oral antiseptic. Additionally, we determined the minimum inhibitory concentration for the synthesized aqueous colloidal Bi2O3 nanoparticles. Keywords: antimycotic agent, antifungal, cytotoxicity
format	article
author	Hernandez-Delgadillo R Velasco-Arias D Martinez-Sanmiguel JJ Diaz D Zumeta-Dube I Arevalo-Ni&ntilde;o K Cabral-Romero C
author_facet	Hernandez-Delgadillo R Velasco-Arias D Martinez-Sanmiguel JJ Diaz D Zumeta-Dube I Arevalo-Ni&ntilde;o K Cabral-Romero C
author_sort	Hernandez-Delgadillo R
title	Bismuth oxide aqueous colloidal nanoparticles inhibit Candida albicans growth and biofilm formation
title_short	Bismuth oxide aqueous colloidal nanoparticles inhibit Candida albicans growth and biofilm formation
title_full	Bismuth oxide aqueous colloidal nanoparticles inhibit Candida albicans growth and biofilm formation
title_fullStr	Bismuth oxide aqueous colloidal nanoparticles inhibit Candida albicans growth and biofilm formation
title_full_unstemmed	Bismuth oxide aqueous colloidal nanoparticles inhibit Candida albicans growth and biofilm formation
title_sort	bismuth oxide aqueous colloidal nanoparticles inhibit candida albicans growth and biofilm formation
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/da666ecfce884f8d9c038d25880831f2
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Bismuth oxide aqueous colloidal nanoparticles inhibit Candida albicans growth and biofilm formation

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