Lack of relationship between cigarette smoking and alcohol use with dysplasia grade in ocular surface squamous neoplasia

Alison D Early, Sarah Adelson, Craig J Miller, Thomas F Mauger Department of Ophthalmology, The Ohio State University Havener Eye Institute, Columbus, OH, USA Objective: To evaluate smoking and alcohol use as risk factors for higher-grade dysplasia in a population of patients with histopathologica...

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Autores principales:	Early AD, Adelson S, Miller CJ, Mauger TF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Ocular surface squamous neoplasia corneal dysplasia conjunctival dysplasia carcinoma in situ squamous cell carcinoma ocular surface tumors. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/da6839e6dfda4ef9b45cadfd648c8b79
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spelling	oai:doaj.org-article:da6839e6dfda4ef9b45cadfd648c8b792021-12-02T04:23:29ZLack of relationship between cigarette smoking and alcohol use with dysplasia grade in ocular surface squamous neoplasia1177-5483https://doaj.org/article/da6839e6dfda4ef9b45cadfd648c8b792018-10-01T00:00:00Zhttps://www.dovepress.com/lack-of-relationship-between-cigarette-smoking-and-alcohol-use-with-dy-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Alison D Early, Sarah Adelson, Craig J Miller, Thomas F Mauger Department of Ophthalmology, The Ohio State University Havener Eye Institute, Columbus, OH, USA Objective: To evaluate smoking and alcohol use as risk factors for higher-grade dysplasia in a population of patients with histopathologically proven ocular surface squamous neoplasia. Materials and methods: This is a retrospective chart review of data extracted from a database comprising demographic information and medical diagnosis information based on International Classification of Disease codes. Outcome measures were analyzed using the Wilcoxon two-sided test, a non-parametric t-test. Results: Database review yielded 35 patients with ocular surface squamous neoplasia lesions proven by histopathologic analysis. The mean age was 64.51 years with SD 17.54 years. Patients were 28.57% female and 71.43% male. Nearly all patients were White (88.57%), and 5.71% were African American, 2.86% Hispanic, and 2.86% Other. There was no significant difference in dysplasia grade between smokers and non-smokers (P=0.7044), those who used alcohol vs did not use alcohol (P=0.2470), those who used tobacco and alcohol vs those who did not (P=0.5117), and those who used either tobacco or alcohol vs those who did not (P=0.8259). Conclusion: No statistically significant relationship was found between high-grade dysplasia and cigarette smoking, alcohol use, or both cigarette smoking and alcohol use. Keywords: ocular surface squamous neoplasia, corneal dysplasia, conjunctival dysplasia, carcinoma in situ, squamous cell carcinoma, ocular surface tumorsEarly ADAdelson SMiller CJMauger TFDove Medical PressarticleOcular surface squamous neoplasiacorneal dysplasiaconjunctival dysplasiacarcinoma in situsquamous cell carcinomaocular surface tumors.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 1901-1904 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ocular surface squamous neoplasia corneal dysplasia conjunctival dysplasia carcinoma in situ squamous cell carcinoma ocular surface tumors. Ophthalmology RE1-994
spellingShingle	Ocular surface squamous neoplasia corneal dysplasia conjunctival dysplasia carcinoma in situ squamous cell carcinoma ocular surface tumors. Ophthalmology RE1-994 Early AD Adelson S Miller CJ Mauger TF Lack of relationship between cigarette smoking and alcohol use with dysplasia grade in ocular surface squamous neoplasia
description	Alison D Early, Sarah Adelson, Craig J Miller, Thomas F Mauger Department of Ophthalmology, The Ohio State University Havener Eye Institute, Columbus, OH, USA Objective: To evaluate smoking and alcohol use as risk factors for higher-grade dysplasia in a population of patients with histopathologically proven ocular surface squamous neoplasia. Materials and methods: This is a retrospective chart review of data extracted from a database comprising demographic information and medical diagnosis information based on International Classification of Disease codes. Outcome measures were analyzed using the Wilcoxon two-sided test, a non-parametric t-test. Results: Database review yielded 35 patients with ocular surface squamous neoplasia lesions proven by histopathologic analysis. The mean age was 64.51 years with SD 17.54 years. Patients were 28.57% female and 71.43% male. Nearly all patients were White (88.57%), and 5.71% were African American, 2.86% Hispanic, and 2.86% Other. There was no significant difference in dysplasia grade between smokers and non-smokers (P=0.7044), those who used alcohol vs did not use alcohol (P=0.2470), those who used tobacco and alcohol vs those who did not (P=0.5117), and those who used either tobacco or alcohol vs those who did not (P=0.8259). Conclusion: No statistically significant relationship was found between high-grade dysplasia and cigarette smoking, alcohol use, or both cigarette smoking and alcohol use. Keywords: ocular surface squamous neoplasia, corneal dysplasia, conjunctival dysplasia, carcinoma in situ, squamous cell carcinoma, ocular surface tumors
format	article
author	Early AD Adelson S Miller CJ Mauger TF
author_facet	Early AD Adelson S Miller CJ Mauger TF
author_sort	Early AD
title	Lack of relationship between cigarette smoking and alcohol use with dysplasia grade in ocular surface squamous neoplasia
title_short	Lack of relationship between cigarette smoking and alcohol use with dysplasia grade in ocular surface squamous neoplasia
title_full	Lack of relationship between cigarette smoking and alcohol use with dysplasia grade in ocular surface squamous neoplasia
title_fullStr	Lack of relationship between cigarette smoking and alcohol use with dysplasia grade in ocular surface squamous neoplasia
title_full_unstemmed	Lack of relationship between cigarette smoking and alcohol use with dysplasia grade in ocular surface squamous neoplasia
title_sort	lack of relationship between cigarette smoking and alcohol use with dysplasia grade in ocular surface squamous neoplasia
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/da6839e6dfda4ef9b45cadfd648c8b79
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_version_	1718401277239492608

Lack of relationship between cigarette smoking and alcohol use with dysplasia grade in ocular surface squamous neoplasia

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