Numerical Simulation: Fluctuation in Background Synaptic Activity Regulates Synaptic Plasticity

Synaptic plasticity is vital for learning and memory in the brain. It consists of long-term potentiation (LTP) and long-term depression (LTD). Spike frequency is one of the major components of synaptic plasticity in the brain, a noisy environment. Recently, we mathematically analyzed the frequency-d...

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Autores principales:	Yuto Takeda, Katsuhiko Hata, Tokio Yamazaki, Masaki Kaneko, Osamu Yokoi, Chengta Tsai, Kazuo Umemura, Tetsuro Nikuni
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	frequency-dependent synaptic plasticity background synaptic activity fluctuation calcium-based model neural noise Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/da73ef2b7e35457fae87f482f74df71d
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spelling	oai:doaj.org-article:da73ef2b7e35457fae87f482f74df71d2021-11-22T07:11:35ZNumerical Simulation: Fluctuation in Background Synaptic Activity Regulates Synaptic Plasticity1662-513710.3389/fnsys.2021.771661https://doaj.org/article/da73ef2b7e35457fae87f482f74df71d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnsys.2021.771661/fullhttps://doaj.org/toc/1662-5137Synaptic plasticity is vital for learning and memory in the brain. It consists of long-term potentiation (LTP) and long-term depression (LTD). Spike frequency is one of the major components of synaptic plasticity in the brain, a noisy environment. Recently, we mathematically analyzed the frequency-dependent synaptic plasticity (FDP) in vivo and found that LTP is more likely to occur with an increase in the frequency of background synaptic activity. Meanwhile, previous studies suggest statistical fluctuation in the amplitude of background synaptic activity. Little is understood, however, about its contribution to synaptic plasticity. To address this issue, we performed numerical simulations of a calcium-based synapse model. Then, we found attenuation of the tendency to become LTD due to an increase in the fluctuation of background synaptic activity, leading to an enhancement of synaptic weight. Our result suggests that the fluctuation affects synaptic plasticity in the brain.Yuto TakedaKatsuhiko HataKatsuhiko HataKatsuhiko HataKatsuhiko HataTokio YamazakiMasaki KanekoMasaki KanekoOsamu YokoiChengta TsaiChengta TsaiKazuo UmemuraTetsuro NikuniFrontiers Media S.A.articlefrequency-dependent synaptic plasticitybackground synaptic activityfluctuationcalcium-based modelneural noiseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Systems Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	frequency-dependent synaptic plasticity background synaptic activity fluctuation calcium-based model neural noise Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	frequency-dependent synaptic plasticity background synaptic activity fluctuation calcium-based model neural noise Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Yuto Takeda Katsuhiko Hata Katsuhiko Hata Katsuhiko Hata Katsuhiko Hata Tokio Yamazaki Masaki Kaneko Masaki Kaneko Osamu Yokoi Chengta Tsai Chengta Tsai Kazuo Umemura Tetsuro Nikuni Numerical Simulation: Fluctuation in Background Synaptic Activity Regulates Synaptic Plasticity
description	Synaptic plasticity is vital for learning and memory in the brain. It consists of long-term potentiation (LTP) and long-term depression (LTD). Spike frequency is one of the major components of synaptic plasticity in the brain, a noisy environment. Recently, we mathematically analyzed the frequency-dependent synaptic plasticity (FDP) in vivo and found that LTP is more likely to occur with an increase in the frequency of background synaptic activity. Meanwhile, previous studies suggest statistical fluctuation in the amplitude of background synaptic activity. Little is understood, however, about its contribution to synaptic plasticity. To address this issue, we performed numerical simulations of a calcium-based synapse model. Then, we found attenuation of the tendency to become LTD due to an increase in the fluctuation of background synaptic activity, leading to an enhancement of synaptic weight. Our result suggests that the fluctuation affects synaptic plasticity in the brain.
format	article
author	Yuto Takeda Katsuhiko Hata Katsuhiko Hata Katsuhiko Hata Katsuhiko Hata Tokio Yamazaki Masaki Kaneko Masaki Kaneko Osamu Yokoi Chengta Tsai Chengta Tsai Kazuo Umemura Tetsuro Nikuni
author_facet	Yuto Takeda Katsuhiko Hata Katsuhiko Hata Katsuhiko Hata Katsuhiko Hata Tokio Yamazaki Masaki Kaneko Masaki Kaneko Osamu Yokoi Chengta Tsai Chengta Tsai Kazuo Umemura Tetsuro Nikuni
author_sort	Yuto Takeda
title	Numerical Simulation: Fluctuation in Background Synaptic Activity Regulates Synaptic Plasticity
title_short	Numerical Simulation: Fluctuation in Background Synaptic Activity Regulates Synaptic Plasticity
title_full	Numerical Simulation: Fluctuation in Background Synaptic Activity Regulates Synaptic Plasticity
title_fullStr	Numerical Simulation: Fluctuation in Background Synaptic Activity Regulates Synaptic Plasticity
title_full_unstemmed	Numerical Simulation: Fluctuation in Background Synaptic Activity Regulates Synaptic Plasticity
title_sort	numerical simulation: fluctuation in background synaptic activity regulates synaptic plasticity
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/da73ef2b7e35457fae87f482f74df71d
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Numerical Simulation: Fluctuation in Background Synaptic Activity Regulates Synaptic Plasticity

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