Growth Hormone Secretagogue Receptor 1A Antagonist JMV2959 Effectively Prevents Morphine Memory Reconsolidation and Relapse

Relapse to drug seeking after prolonged abstinence is a major problem in the clinical treatment of drug addiction. The use of pharmacological interventions to disrupt established drug reward memories is a promising strategy for the treatment of drug addiction. A growth hormone secretagogue receptor...

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Autores principales:	Jing Zhao, Xinyu Du, Mingzhu Chen, Shimin Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	conditioned place preference morphine relapse addiction ghrelin antagonism JMV2959 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/da787d7125e34cd289624a7d8bd2fd1d
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spelling	oai:doaj.org-article:da787d7125e34cd289624a7d8bd2fd1d2021-12-01T12:19:59ZGrowth Hormone Secretagogue Receptor 1A Antagonist JMV2959 Effectively Prevents Morphine Memory Reconsolidation and Relapse1663-981210.3389/fphar.2021.718615https://doaj.org/article/da787d7125e34cd289624a7d8bd2fd1d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.718615/fullhttps://doaj.org/toc/1663-9812Relapse to drug seeking after prolonged abstinence is a major problem in the clinical treatment of drug addiction. The use of pharmacological interventions to disrupt established drug reward memories is a promising strategy for the treatment of drug addiction. A growth hormone secretagogue receptor 1 A antagonist, JMV2959, has been shown to reduce morphine-induced conditioned place preference (CPP) in rats within hours of intervention; thus, JMV2959 is a potential candidate for drug addiction treatment. However, the effect of JMV2959 on reconsolidation to disrupt drug seeking remains unknown. In this study, we assessed the effect of JMV2959 on morphine induced memory reconsolidation to inhibit drug seeking after drug withdrawal. Our results showed that the administration of JMV2959 (6 mg/kg) significantly reduced environmental cue induced CPP, which suggested a preventive effect of JMV2959 on morphine induced memory reconsolidation. Additionally, JMV2959 administration significantly altered the locomotor activity and food and water intake but did not significantly alter the natural reward preference. We concluded that JMV2959 may be an effective candidate to treat drug addiction.Jing ZhaoXinyu DuMingzhu ChenShimin ZhuFrontiers Media S.A.articleconditioned place preferencemorphine relapseaddictionghrelin antagonismJMV2959Therapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	conditioned place preference morphine relapse addiction ghrelin antagonism JMV2959 Therapeutics. Pharmacology RM1-950
spellingShingle	conditioned place preference morphine relapse addiction ghrelin antagonism JMV2959 Therapeutics. Pharmacology RM1-950 Jing Zhao Xinyu Du Mingzhu Chen Shimin Zhu Growth Hormone Secretagogue Receptor 1A Antagonist JMV2959 Effectively Prevents Morphine Memory Reconsolidation and Relapse
description	Relapse to drug seeking after prolonged abstinence is a major problem in the clinical treatment of drug addiction. The use of pharmacological interventions to disrupt established drug reward memories is a promising strategy for the treatment of drug addiction. A growth hormone secretagogue receptor 1 A antagonist, JMV2959, has been shown to reduce morphine-induced conditioned place preference (CPP) in rats within hours of intervention; thus, JMV2959 is a potential candidate for drug addiction treatment. However, the effect of JMV2959 on reconsolidation to disrupt drug seeking remains unknown. In this study, we assessed the effect of JMV2959 on morphine induced memory reconsolidation to inhibit drug seeking after drug withdrawal. Our results showed that the administration of JMV2959 (6 mg/kg) significantly reduced environmental cue induced CPP, which suggested a preventive effect of JMV2959 on morphine induced memory reconsolidation. Additionally, JMV2959 administration significantly altered the locomotor activity and food and water intake but did not significantly alter the natural reward preference. We concluded that JMV2959 may be an effective candidate to treat drug addiction.
format	article
author	Jing Zhao Xinyu Du Mingzhu Chen Shimin Zhu
author_facet	Jing Zhao Xinyu Du Mingzhu Chen Shimin Zhu
author_sort	Jing Zhao
title	Growth Hormone Secretagogue Receptor 1A Antagonist JMV2959 Effectively Prevents Morphine Memory Reconsolidation and Relapse
title_short	Growth Hormone Secretagogue Receptor 1A Antagonist JMV2959 Effectively Prevents Morphine Memory Reconsolidation and Relapse
title_full	Growth Hormone Secretagogue Receptor 1A Antagonist JMV2959 Effectively Prevents Morphine Memory Reconsolidation and Relapse
title_fullStr	Growth Hormone Secretagogue Receptor 1A Antagonist JMV2959 Effectively Prevents Morphine Memory Reconsolidation and Relapse
title_full_unstemmed	Growth Hormone Secretagogue Receptor 1A Antagonist JMV2959 Effectively Prevents Morphine Memory Reconsolidation and Relapse
title_sort	growth hormone secretagogue receptor 1a antagonist jmv2959 effectively prevents morphine memory reconsolidation and relapse
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/da787d7125e34cd289624a7d8bd2fd1d
work_keys_str_mv	AT jingzhao growthhormonesecretagoguereceptor1aantagonistjmv2959effectivelypreventsmorphinememoryreconsolidationandrelapse AT xinyudu growthhormonesecretagoguereceptor1aantagonistjmv2959effectivelypreventsmorphinememoryreconsolidationandrelapse AT mingzhuchen growthhormonesecretagoguereceptor1aantagonistjmv2959effectivelypreventsmorphinememoryreconsolidationandrelapse AT shiminzhu growthhormonesecretagoguereceptor1aantagonistjmv2959effectivelypreventsmorphinememoryreconsolidationandrelapse
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Growth Hormone Secretagogue Receptor 1A Antagonist JMV2959 Effectively Prevents Morphine Memory Reconsolidation and Relapse

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