Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus

Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus

Foxn1 is involved in thymic epithelial cell (TEC) and CD8+T cell development. Here the authors show this development requires Foxn1 binding proximal to, and inducing transcription of, the gene encoding β5t in cortical TECs.

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Autores principales: Muhammad Myn Uddin, Izumi Ohigashi, Ryo Motosugi, Tomomi Nakayama, Mie Sakata, Jun Hamazaki, Yasumasa Nishito, Immanuel Rode, Keiji Tanaka, Tatsuya Takemoto, Shigeo Murata, Yousuke Takahama
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/da7be85cf2f6425ca21a3d52a9dcec58
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spelling oai:doaj.org-article:da7be85cf2f6425ca21a3d52a9dcec582021-12-02T15:38:36ZFoxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus10.1038/ncomms144192041-1723https://doaj.org/article/da7be85cf2f6425ca21a3d52a9dcec582017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14419https://doaj.org/toc/2041-1723Foxn1 is involved in thymic epithelial cell (TEC) and CD8+T cell development. Here the authors show this development requires Foxn1 binding proximal to, and inducing transcription of, the gene encoding β5t in cortical TECs.Muhammad Myn UddinIzumi OhigashiRyo MotosugiTomomi NakayamaMie SakataJun HamazakiYasumasa NishitoImmanuel RodeKeiji TanakaTatsuya TakemotoShigeo MurataYousuke TakahamaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Muhammad Myn Uddin
Izumi Ohigashi
Ryo Motosugi
Tomomi Nakayama
Mie Sakata
Jun Hamazaki
Yasumasa Nishito
Immanuel Rode
Keiji Tanaka
Tatsuya Takemoto
Shigeo Murata
Yousuke Takahama
Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus
description Foxn1 is involved in thymic epithelial cell (TEC) and CD8+T cell development. Here the authors show this development requires Foxn1 binding proximal to, and inducing transcription of, the gene encoding β5t in cortical TECs.
format article
author Muhammad Myn Uddin
Izumi Ohigashi
Ryo Motosugi
Tomomi Nakayama
Mie Sakata
Jun Hamazaki
Yasumasa Nishito
Immanuel Rode
Keiji Tanaka
Tatsuya Takemoto
Shigeo Murata
Yousuke Takahama
author_facet Muhammad Myn Uddin
Izumi Ohigashi
Ryo Motosugi
Tomomi Nakayama
Mie Sakata
Jun Hamazaki
Yasumasa Nishito
Immanuel Rode
Keiji Tanaka
Tatsuya Takemoto
Shigeo Murata
Yousuke Takahama
author_sort Muhammad Myn Uddin
title Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus
title_short Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus
title_full Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus
title_fullStr Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus
title_full_unstemmed Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus
title_sort foxn1-β5t transcriptional axis controls cd8+ t-cell production in the thymus
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/da7be85cf2f6425ca21a3d52a9dcec58
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