Feasibility of a surveillance programme based on gargle samples and pool testing to prevent SARS-CoV-2 outbreaks in schools

Abstract School closures have a negative impact on physical and mental well-being, and education, of children and adolescents. A surveillance programme to detect asymptomatic SARS-CoV-2 infection could allow schools to remain open, while protecting the vulnerable. We assessed the feasibility of a pr...

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Autores principales:	Catherine M. Sweeney-Reed, Doreen Wolff, Sarah Hörnschemeyer, Henriette Faßhauer, Antonia Haase, Dirk Schomburg, Jakob Niggel, Michael Kabesch, Christian Apfelbacher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/da7e3325620b4f3b8e0028f94d5cd360
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spelling	oai:doaj.org-article:da7e3325620b4f3b8e0028f94d5cd3602021-12-02T19:16:59ZFeasibility of a surveillance programme based on gargle samples and pool testing to prevent SARS-CoV-2 outbreaks in schools10.1038/s41598-021-98849-12045-2322https://doaj.org/article/da7e3325620b4f3b8e0028f94d5cd3602021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98849-1https://doaj.org/toc/2045-2322Abstract School closures have a negative impact on physical and mental well-being, and education, of children and adolescents. A surveillance programme to detect asymptomatic SARS-CoV-2 infection could allow schools to remain open, while protecting the vulnerable. We assessed the feasibility of a programme employing gargle samples and pool testing of individually extracted RNA using rRT-qPCR in a primary and a secondary school in Germany, based on programme logistics and acceptance. Twice a week, five participants per class were selected to provide samples, using an algorithm weighted by a risk-based priority score to increase likelihood of case detection. The positive response rate was 54.8% (550 of 1003 pupils). Logistics evaluation revealed the rate-limiting steps: completing the regular pre-test questionnaire and handing in the samples. Acceptance questionnaire responses indicated strong support for research into developing a surveillance programme and a positive evaluation of gargle tests. Participation was voluntary. As not all pupils participated, individual reminders could lead to participant identification. School-wide implementation of the programme for infection monitoring purposes would enable reminders to be given to all school pupils to address these steps, without compromising participant anonymity. Such a programme would provide a feasible means to monitor asymptomatic respiratory tract infection in schools.Catherine M. Sweeney-ReedDoreen WolffSarah HörnschemeyerHenriette FaßhauerAntonia HaaseDirk SchomburgJakob NiggelMichael KabeschChristian ApfelbacherNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Catherine M. Sweeney-Reed Doreen Wolff Sarah Hörnschemeyer Henriette Faßhauer Antonia Haase Dirk Schomburg Jakob Niggel Michael Kabesch Christian Apfelbacher Feasibility of a surveillance programme based on gargle samples and pool testing to prevent SARS-CoV-2 outbreaks in schools
description	Abstract School closures have a negative impact on physical and mental well-being, and education, of children and adolescents. A surveillance programme to detect asymptomatic SARS-CoV-2 infection could allow schools to remain open, while protecting the vulnerable. We assessed the feasibility of a programme employing gargle samples and pool testing of individually extracted RNA using rRT-qPCR in a primary and a secondary school in Germany, based on programme logistics and acceptance. Twice a week, five participants per class were selected to provide samples, using an algorithm weighted by a risk-based priority score to increase likelihood of case detection. The positive response rate was 54.8% (550 of 1003 pupils). Logistics evaluation revealed the rate-limiting steps: completing the regular pre-test questionnaire and handing in the samples. Acceptance questionnaire responses indicated strong support for research into developing a surveillance programme and a positive evaluation of gargle tests. Participation was voluntary. As not all pupils participated, individual reminders could lead to participant identification. School-wide implementation of the programme for infection monitoring purposes would enable reminders to be given to all school pupils to address these steps, without compromising participant anonymity. Such a programme would provide a feasible means to monitor asymptomatic respiratory tract infection in schools.
format	article
author	Catherine M. Sweeney-Reed Doreen Wolff Sarah Hörnschemeyer Henriette Faßhauer Antonia Haase Dirk Schomburg Jakob Niggel Michael Kabesch Christian Apfelbacher
author_facet	Catherine M. Sweeney-Reed Doreen Wolff Sarah Hörnschemeyer Henriette Faßhauer Antonia Haase Dirk Schomburg Jakob Niggel Michael Kabesch Christian Apfelbacher
author_sort	Catherine M. Sweeney-Reed
title	Feasibility of a surveillance programme based on gargle samples and pool testing to prevent SARS-CoV-2 outbreaks in schools
title_short	Feasibility of a surveillance programme based on gargle samples and pool testing to prevent SARS-CoV-2 outbreaks in schools
title_full	Feasibility of a surveillance programme based on gargle samples and pool testing to prevent SARS-CoV-2 outbreaks in schools
title_fullStr	Feasibility of a surveillance programme based on gargle samples and pool testing to prevent SARS-CoV-2 outbreaks in schools
title_full_unstemmed	Feasibility of a surveillance programme based on gargle samples and pool testing to prevent SARS-CoV-2 outbreaks in schools
title_sort	feasibility of a surveillance programme based on gargle samples and pool testing to prevent sars-cov-2 outbreaks in schools
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/da7e3325620b4f3b8e0028f94d5cd360
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Feasibility of a surveillance programme based on gargle samples and pool testing to prevent SARS-CoV-2 outbreaks in schools

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