A First in Human Trial Implanting Microalgae Shows Safety of Photosynthetic Therapy for the Effective Treatment of Full Thickness Skin Wounds
Insufficient oxygen supply represents a relevant issue in several fields of human physiology and medicine. It has been suggested that the implantation of photosynthetic cells can provide oxygen to tissues in the absence of a vascular supply. This approach has been demonstrated to be successful in se...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:da7ed95f3aad4c8389713aa53bccfc3c2021-12-01T15:49:33ZA First in Human Trial Implanting Microalgae Shows Safety of Photosynthetic Therapy for the Effective Treatment of Full Thickness Skin Wounds2296-858X10.3389/fmed.2021.772324https://doaj.org/article/da7ed95f3aad4c8389713aa53bccfc3c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.772324/fullhttps://doaj.org/toc/2296-858XInsufficient oxygen supply represents a relevant issue in several fields of human physiology and medicine. It has been suggested that the implantation of photosynthetic cells can provide oxygen to tissues in the absence of a vascular supply. This approach has been demonstrated to be successful in several in vitro and in vivo models; however, no data is available about their safety in human patients. Here, an early phase-1 clinical trial (ClinicalTrials.gov identifier: NCT03960164, https://clinicaltrials.gov/ct2/show/NCT03960164) is presented to evaluate the safety and feasibility of implanting photosynthetic scaffolds for dermal regeneration in eight patients with full-thickness skin wounds. Overall, this trial shows that the presence of the photosynthetic microalgae Chlamydomonas reinhardtii in the implanted scaffolds did not trigger any deleterious local or systemic immune responses in a 90 days follow-up, allowing full tissue regeneration in humans. The results presented here represent the first attempt to treat patients with photosynthetic cells, supporting the translation of photosynthetic therapies into clinics.Clinical Trial Registration:www.clinicaltrials.gov/ct2/show/NCT03960164, identifier: NCT03960164.Miguel Luis ObaídJuan Pablo CamachoMarianne BrenetRocío Corrales-OrovioRocío Corrales-OrovioFelipe CarvajalXimena MartorellConsuelo WernerValeska SimónJuan VarasWilfredo CalderónWilfredo CalderónChristian Dani GuzmánMaría Rosa BonoSebastián San MartínAntonio Eblen-ZajjurAntonio Eblen-ZajjurJosé Tomás EgañaFrontiers Media S.A.articlehuman photosynthesisclinical trialskin regenerationmicroalgaephotosynthetic biomaterialskin woundsMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
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human photosynthesis clinical trial skin regeneration microalgae photosynthetic biomaterial skin wounds Medicine (General) R5-920 |
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human photosynthesis clinical trial skin regeneration microalgae photosynthetic biomaterial skin wounds Medicine (General) R5-920 Miguel Luis Obaíd Juan Pablo Camacho Marianne Brenet Rocío Corrales-Orovio Rocío Corrales-Orovio Felipe Carvajal Ximena Martorell Consuelo Werner Valeska Simón Juan Varas Wilfredo Calderón Wilfredo Calderón Christian Dani Guzmán María Rosa Bono Sebastián San Martín Antonio Eblen-Zajjur Antonio Eblen-Zajjur José Tomás Egaña A First in Human Trial Implanting Microalgae Shows Safety of Photosynthetic Therapy for the Effective Treatment of Full Thickness Skin Wounds |
| description |
Insufficient oxygen supply represents a relevant issue in several fields of human physiology and medicine. It has been suggested that the implantation of photosynthetic cells can provide oxygen to tissues in the absence of a vascular supply. This approach has been demonstrated to be successful in several in vitro and in vivo models; however, no data is available about their safety in human patients. Here, an early phase-1 clinical trial (ClinicalTrials.gov identifier: NCT03960164, https://clinicaltrials.gov/ct2/show/NCT03960164) is presented to evaluate the safety and feasibility of implanting photosynthetic scaffolds for dermal regeneration in eight patients with full-thickness skin wounds. Overall, this trial shows that the presence of the photosynthetic microalgae Chlamydomonas reinhardtii in the implanted scaffolds did not trigger any deleterious local or systemic immune responses in a 90 days follow-up, allowing full tissue regeneration in humans. The results presented here represent the first attempt to treat patients with photosynthetic cells, supporting the translation of photosynthetic therapies into clinics.Clinical Trial Registration:www.clinicaltrials.gov/ct2/show/NCT03960164, identifier: NCT03960164. |
| format |
article |
| author |
Miguel Luis Obaíd Juan Pablo Camacho Marianne Brenet Rocío Corrales-Orovio Rocío Corrales-Orovio Felipe Carvajal Ximena Martorell Consuelo Werner Valeska Simón Juan Varas Wilfredo Calderón Wilfredo Calderón Christian Dani Guzmán María Rosa Bono Sebastián San Martín Antonio Eblen-Zajjur Antonio Eblen-Zajjur José Tomás Egaña |
| author_facet |
Miguel Luis Obaíd Juan Pablo Camacho Marianne Brenet Rocío Corrales-Orovio Rocío Corrales-Orovio Felipe Carvajal Ximena Martorell Consuelo Werner Valeska Simón Juan Varas Wilfredo Calderón Wilfredo Calderón Christian Dani Guzmán María Rosa Bono Sebastián San Martín Antonio Eblen-Zajjur Antonio Eblen-Zajjur José Tomás Egaña |
| author_sort |
Miguel Luis Obaíd |
| title |
A First in Human Trial Implanting Microalgae Shows Safety of Photosynthetic Therapy for the Effective Treatment of Full Thickness Skin Wounds |
| title_short |
A First in Human Trial Implanting Microalgae Shows Safety of Photosynthetic Therapy for the Effective Treatment of Full Thickness Skin Wounds |
| title_full |
A First in Human Trial Implanting Microalgae Shows Safety of Photosynthetic Therapy for the Effective Treatment of Full Thickness Skin Wounds |
| title_fullStr |
A First in Human Trial Implanting Microalgae Shows Safety of Photosynthetic Therapy for the Effective Treatment of Full Thickness Skin Wounds |
| title_full_unstemmed |
A First in Human Trial Implanting Microalgae Shows Safety of Photosynthetic Therapy for the Effective Treatment of Full Thickness Skin Wounds |
| title_sort |
first in human trial implanting microalgae shows safety of photosynthetic therapy for the effective treatment of full thickness skin wounds |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/da7ed95f3aad4c8389713aa53bccfc3c |
| work_keys_str_mv |
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