Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis

Caspases are most closely associated with cell death, but many have other cellular functions. Here, Das et al. find that upon metabolic stress, caspase-10 cleaves ACLY to regulate metabolic homeostasis and epigenetic reprogramming by altering Acetyl-CoA levels.

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Main Authors:	Rajni Kumari, Ruhi S. Deshmukh, Sanjeev Das
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/da7fe8cd0b86475f9a5a54a875ed8c64
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spelling	oai:doaj.org-article:da7fe8cd0b86475f9a5a54a875ed8c642021-12-02T15:36:04ZCaspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis10.1038/s41467-019-12194-62041-1723https://doaj.org/article/da7fe8cd0b86475f9a5a54a875ed8c642019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12194-6https://doaj.org/toc/2041-1723Caspases are most closely associated with cell death, but many have other cellular functions. Here, Das et al. find that upon metabolic stress, caspase-10 cleaves ACLY to regulate metabolic homeostasis and epigenetic reprogramming by altering Acetyl-CoA levels.Rajni KumariRuhi S. DeshmukhSanjeev DasNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rajni Kumari Ruhi S. Deshmukh Sanjeev Das Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis
description	Caspases are most closely associated with cell death, but many have other cellular functions. Here, Das et al. find that upon metabolic stress, caspase-10 cleaves ACLY to regulate metabolic homeostasis and epigenetic reprogramming by altering Acetyl-CoA levels.
format	article
author	Rajni Kumari Ruhi S. Deshmukh Sanjeev Das
author_facet	Rajni Kumari Ruhi S. Deshmukh Sanjeev Das
author_sort	Rajni Kumari
title	Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis
title_short	Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis
title_full	Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis
title_fullStr	Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis
title_full_unstemmed	Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis
title_sort	caspase-10 inhibits atp-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/da7fe8cd0b86475f9a5a54a875ed8c64
work_keys_str_mv	AT rajnikumari caspase10inhibitsatpcitratelyasemediatedmetabolicandepigeneticreprogrammingtosuppresstumorigenesis AT ruhisdeshmukh caspase10inhibitsatpcitratelyasemediatedmetabolicandepigeneticreprogrammingtosuppresstumorigenesis AT sanjeevdas caspase10inhibitsatpcitratelyasemediatedmetabolicandepigeneticreprogrammingtosuppresstumorigenesis
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Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis

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