CVD graphene as an electrochemical sensing platform for simultaneous detection of biomolecules
Abstract The development of electrochemical biosensors for the simultaneous detection of ascorbic acid (AA), dopamine (DA), uric acid (UA), tryptophan (Trp), and nitrite ( $${{\rm{NO}}}_{2}^{-}$$ NO 2 − ) in human serum is reported in this work. Free-standing graphene nanosheets were fabricated on T...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/da821df943614428b828023f6072c0ea |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:da821df943614428b828023f6072c0ea |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:da821df943614428b828023f6072c0ea2021-12-02T16:07:48ZCVD graphene as an electrochemical sensing platform for simultaneous detection of biomolecules10.1038/s41598-017-07646-22045-2322https://doaj.org/article/da821df943614428b828023f6072c0ea2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07646-2https://doaj.org/toc/2045-2322Abstract The development of electrochemical biosensors for the simultaneous detection of ascorbic acid (AA), dopamine (DA), uric acid (UA), tryptophan (Trp), and nitrite ( $${{\rm{NO}}}_{2}^{-}$$ NO 2 − ) in human serum is reported in this work. Free-standing graphene nanosheets were fabricated on Ta wire using the chemical vapor deposition (CVD) method. CVD graphene, which here served as a sensing platform, provided a highly sensitive and selective option, with detection limits of AA, DA, UA, Trp, and $${{\rm{NO}}}_{2}^{-}$$ NO 2 − of 1.58, 0.06, 0.09, 0.10, and 6.45 μM (S/N = 3), respectively. The high selectivity of the electrode is here explained by a relationship between the bandgap energy of analyte and the Fermi level of graphene. The high sensitivity in the oxidation current was determined by analyzing the influence of the high surface area and chemical structure of free-standing graphene nanosheets on analyte adsorption capacity. This finding strongly indicates that the CVD graphene electrode can be used as a biosensor to detect five analytes in human serum.Xiaodan WangDelan GaoMingji LiHongji LiCuiping LiXiaoguo WuBaohe YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Xiaodan Wang Delan Gao Mingji Li Hongji Li Cuiping Li Xiaoguo Wu Baohe Yang CVD graphene as an electrochemical sensing platform for simultaneous detection of biomolecules |
| description |
Abstract The development of electrochemical biosensors for the simultaneous detection of ascorbic acid (AA), dopamine (DA), uric acid (UA), tryptophan (Trp), and nitrite ( $${{\rm{NO}}}_{2}^{-}$$ NO 2 − ) in human serum is reported in this work. Free-standing graphene nanosheets were fabricated on Ta wire using the chemical vapor deposition (CVD) method. CVD graphene, which here served as a sensing platform, provided a highly sensitive and selective option, with detection limits of AA, DA, UA, Trp, and $${{\rm{NO}}}_{2}^{-}$$ NO 2 − of 1.58, 0.06, 0.09, 0.10, and 6.45 μM (S/N = 3), respectively. The high selectivity of the electrode is here explained by a relationship between the bandgap energy of analyte and the Fermi level of graphene. The high sensitivity in the oxidation current was determined by analyzing the influence of the high surface area and chemical structure of free-standing graphene nanosheets on analyte adsorption capacity. This finding strongly indicates that the CVD graphene electrode can be used as a biosensor to detect five analytes in human serum. |
| format |
article |
| author |
Xiaodan Wang Delan Gao Mingji Li Hongji Li Cuiping Li Xiaoguo Wu Baohe Yang |
| author_facet |
Xiaodan Wang Delan Gao Mingji Li Hongji Li Cuiping Li Xiaoguo Wu Baohe Yang |
| author_sort |
Xiaodan Wang |
| title |
CVD graphene as an electrochemical sensing platform for simultaneous detection of biomolecules |
| title_short |
CVD graphene as an electrochemical sensing platform for simultaneous detection of biomolecules |
| title_full |
CVD graphene as an electrochemical sensing platform for simultaneous detection of biomolecules |
| title_fullStr |
CVD graphene as an electrochemical sensing platform for simultaneous detection of biomolecules |
| title_full_unstemmed |
CVD graphene as an electrochemical sensing platform for simultaneous detection of biomolecules |
| title_sort |
cvd graphene as an electrochemical sensing platform for simultaneous detection of biomolecules |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/da821df943614428b828023f6072c0ea |
| work_keys_str_mv |
AT xiaodanwang cvdgrapheneasanelectrochemicalsensingplatformforsimultaneousdetectionofbiomolecules AT delangao cvdgrapheneasanelectrochemicalsensingplatformforsimultaneousdetectionofbiomolecules AT mingjili cvdgrapheneasanelectrochemicalsensingplatformforsimultaneousdetectionofbiomolecules AT hongjili cvdgrapheneasanelectrochemicalsensingplatformforsimultaneousdetectionofbiomolecules AT cuipingli cvdgrapheneasanelectrochemicalsensingplatformforsimultaneousdetectionofbiomolecules AT xiaoguowu cvdgrapheneasanelectrochemicalsensingplatformforsimultaneousdetectionofbiomolecules AT baoheyang cvdgrapheneasanelectrochemicalsensingplatformforsimultaneousdetectionofbiomolecules |
| _version_ |
1718384749247987712 |