Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics

The plasmid-borne mcr-1 gene confers resistance to the antibiotic colistin. Here, MacNair et al. show that mcr-1 positive bacteria are however susceptible to colistin-mediated disruption of the outer membrane, and can be killed in vitro and in vivo by combining colistin with other antibiotics.

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Bibliographic Details
Main Authors:	Craig R. MacNair, Jonathan M. Stokes, Lindsey A. Carfrae, Aline A. Fiebig-Comyn, Brian K. Coombes, Michael R. Mulvey, Eric D. Brown
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/da87016d954b431591b5fc0f923e52e7
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id	oai:doaj.org-article:da87016d954b431591b5fc0f923e52e7
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spelling	oai:doaj.org-article:da87016d954b431591b5fc0f923e52e72021-12-02T17:31:28ZOvercoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics10.1038/s41467-018-02875-z2041-1723https://doaj.org/article/da87016d954b431591b5fc0f923e52e72018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02875-zhttps://doaj.org/toc/2041-1723The plasmid-borne mcr-1 gene confers resistance to the antibiotic colistin. Here, MacNair et al. show that mcr-1 positive bacteria are however susceptible to colistin-mediated disruption of the outer membrane, and can be killed in vitro and in vivo by combining colistin with other antibiotics.Craig R. MacNairJonathan M. StokesLindsey A. CarfraeAline A. Fiebig-ComynBrian K. CoombesMichael R. MulveyEric D. BrownNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Craig R. MacNair Jonathan M. Stokes Lindsey A. Carfrae Aline A. Fiebig-Comyn Brian K. Coombes Michael R. Mulvey Eric D. Brown Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics
description	The plasmid-borne mcr-1 gene confers resistance to the antibiotic colistin. Here, MacNair et al. show that mcr-1 positive bacteria are however susceptible to colistin-mediated disruption of the outer membrane, and can be killed in vitro and in vivo by combining colistin with other antibiotics.
format	article
author	Craig R. MacNair Jonathan M. Stokes Lindsey A. Carfrae Aline A. Fiebig-Comyn Brian K. Coombes Michael R. Mulvey Eric D. Brown
author_facet	Craig R. MacNair Jonathan M. Stokes Lindsey A. Carfrae Aline A. Fiebig-Comyn Brian K. Coombes Michael R. Mulvey Eric D. Brown
author_sort	Craig R. MacNair
title	Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics
title_short	Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics
title_full	Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics
title_fullStr	Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics
title_full_unstemmed	Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics
title_sort	overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/da87016d954b431591b5fc0f923e52e7
work_keys_str_mv	AT craigrmacnair overcomingmcr1mediatedcolistinresistancewithcolistinincombinationwithotherantibiotics AT jonathanmstokes overcomingmcr1mediatedcolistinresistancewithcolistinincombinationwithotherantibiotics AT lindseyacarfrae overcomingmcr1mediatedcolistinresistancewithcolistinincombinationwithotherantibiotics AT alineafiebigcomyn overcomingmcr1mediatedcolistinresistancewithcolistinincombinationwithotherantibiotics AT briankcoombes overcomingmcr1mediatedcolistinresistancewithcolistinincombinationwithotherantibiotics AT michaelrmulvey overcomingmcr1mediatedcolistinresistancewithcolistinincombinationwithotherantibiotics AT ericdbrown overcomingmcr1mediatedcolistinresistancewithcolistinincombinationwithotherantibiotics
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Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics

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