THE CELLULAR AND HUMORAL IMMUNITY STATE DEPENDING ON THE OUTCOME OF A WIDESPREAD PURULENT PERITONITIS

The aim of the study was to examine the state of cellular and humoral immunity in patients with widespread purulent peritonitis (WPP) in depending on the disease outcome. The study involved 50 patients with community-acquired and hospital origin WPP. The testing of blood lymphocyte phenotype was per...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. A. Savchenko, A. G. Borisov, D. E. Zdzitoveckij, I. V. Kudryavtsev
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2015
Materias:	immune system peritonitis t-lymphocyte b-lymphocyte cytokines Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/da8979f9bb4249a8a03845f0a1cde624
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:da8979f9bb4249a8a03845f0a1cde624
record_format	dspace
spelling	oai:doaj.org-article:da8979f9bb4249a8a03845f0a1cde6242021-11-22T07:09:47ZTHE CELLULAR AND HUMORAL IMMUNITY STATE DEPENDING ON THE OUTCOME OF A WIDESPREAD PURULENT PERITONITIS2220-76192313-739810.15789/2220-7619-2015-1-63-70https://doaj.org/article/da8979f9bb4249a8a03845f0a1cde6242015-04-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/275https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398The aim of the study was to examine the state of cellular and humoral immunity in patients with widespread purulent peritonitis (WPP) in depending on the disease outcome. The study involved 50 patients with community-acquired and hospital origin WPP. The testing of blood lymphocyte phenotype was performed by flow cytometry. The concentration of immunoglobulins and cytokines were measured by ELISA. It was established that the immune system state by WPP is characterized by leukocytosis, relative lymphopenia, increasing concentrations of pro-inflammatory cytokines, as well as decrease of the cytotoxic and activated T-lymphocytes content. The state of the cellular immunity in case of unfavorable outcome of the WPP is characterized by decreased of the γδT-lymphocytes and NKT-cells levels with increasing amounts of the B1-cells. The immune system state in case of a favorable outcome of the WPP is characterized by a decrease in the number of NK-cells in peripheral blood and increased levels of Th2-lymphocytes. Increasing of the Th2-cells number determines the increase in stimulating effects of T-cell on the humoral immunity, that is manifested in increasing concentrations of IL-4 and IgA, which is an important factor in the immunopathogenesis of the WPP determining its favorable outcome.A. A. SavchenkoA. G. BorisovD. E. ZdzitoveckijI. V. KudryavtsevSankt-Peterburg : NIIÈM imeni Pasteraarticleimmune systemperitonitist-lymphocyteb-lymphocytecytokinesInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 5, Iss 1, Pp 63-70 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	immune system peritonitis t-lymphocyte b-lymphocyte cytokines Infectious and parasitic diseases RC109-216
spellingShingle	immune system peritonitis t-lymphocyte b-lymphocyte cytokines Infectious and parasitic diseases RC109-216 A. A. Savchenko A. G. Borisov D. E. Zdzitoveckij I. V. Kudryavtsev THE CELLULAR AND HUMORAL IMMUNITY STATE DEPENDING ON THE OUTCOME OF A WIDESPREAD PURULENT PERITONITIS
description	The aim of the study was to examine the state of cellular and humoral immunity in patients with widespread purulent peritonitis (WPP) in depending on the disease outcome. The study involved 50 patients with community-acquired and hospital origin WPP. The testing of blood lymphocyte phenotype was performed by flow cytometry. The concentration of immunoglobulins and cytokines were measured by ELISA. It was established that the immune system state by WPP is characterized by leukocytosis, relative lymphopenia, increasing concentrations of pro-inflammatory cytokines, as well as decrease of the cytotoxic and activated T-lymphocytes content. The state of the cellular immunity in case of unfavorable outcome of the WPP is characterized by decreased of the γδT-lymphocytes and NKT-cells levels with increasing amounts of the B1-cells. The immune system state in case of a favorable outcome of the WPP is characterized by a decrease in the number of NK-cells in peripheral blood and increased levels of Th2-lymphocytes. Increasing of the Th2-cells number determines the increase in stimulating effects of T-cell on the humoral immunity, that is manifested in increasing concentrations of IL-4 and IgA, which is an important factor in the immunopathogenesis of the WPP determining its favorable outcome.
format	article
author	A. A. Savchenko A. G. Borisov D. E. Zdzitoveckij I. V. Kudryavtsev
author_facet	A. A. Savchenko A. G. Borisov D. E. Zdzitoveckij I. V. Kudryavtsev
author_sort	A. A. Savchenko
title	THE CELLULAR AND HUMORAL IMMUNITY STATE DEPENDING ON THE OUTCOME OF A WIDESPREAD PURULENT PERITONITIS
title_short	THE CELLULAR AND HUMORAL IMMUNITY STATE DEPENDING ON THE OUTCOME OF A WIDESPREAD PURULENT PERITONITIS
title_full	THE CELLULAR AND HUMORAL IMMUNITY STATE DEPENDING ON THE OUTCOME OF A WIDESPREAD PURULENT PERITONITIS
title_fullStr	THE CELLULAR AND HUMORAL IMMUNITY STATE DEPENDING ON THE OUTCOME OF A WIDESPREAD PURULENT PERITONITIS
title_full_unstemmed	THE CELLULAR AND HUMORAL IMMUNITY STATE DEPENDING ON THE OUTCOME OF A WIDESPREAD PURULENT PERITONITIS
title_sort	cellular and humoral immunity state depending on the outcome of a widespread purulent peritonitis
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2015
url	https://doaj.org/article/da8979f9bb4249a8a03845f0a1cde624
work_keys_str_mv	AT aasavchenko thecellularandhumoralimmunitystatedependingontheoutcomeofawidespreadpurulentperitonitis AT agborisov thecellularandhumoralimmunitystatedependingontheoutcomeofawidespreadpurulentperitonitis AT dezdzitoveckij thecellularandhumoralimmunitystatedependingontheoutcomeofawidespreadpurulentperitonitis AT ivkudryavtsev thecellularandhumoralimmunitystatedependingontheoutcomeofawidespreadpurulentperitonitis AT aasavchenko cellularandhumoralimmunitystatedependingontheoutcomeofawidespreadpurulentperitonitis AT agborisov cellularandhumoralimmunitystatedependingontheoutcomeofawidespreadpurulentperitonitis AT dezdzitoveckij cellularandhumoralimmunitystatedependingontheoutcomeofawidespreadpurulentperitonitis AT ivkudryavtsev cellularandhumoralimmunitystatedependingontheoutcomeofawidespreadpurulentperitonitis
_version_	1718418073643384832

THE CELLULAR AND HUMORAL IMMUNITY STATE DEPENDING ON THE OUTCOME OF A WIDESPREAD PURULENT PERITONITIS

Ejemplares similares