Morphologic characteristics of nevi associated with melanoma: a clinical, dermatoscopic and histopathologic analysis

Background: The aim of this retrospective study was to determine the frequency of nevus-associated melanomas and to better characterize the preexisting nevus from a histopathologic, clinical and dermatoscopic point of view. Methods: We reviewed the histopathologic slides of a consecutive series...

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Autores principales:	Temeida Alendar, Harald Kittler
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2018
Materias:	nevus melanoma dermatopathology dermatoscopy Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/da9714dee48543c8a539df76adb49d97
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spelling	oai:doaj.org-article:da9714dee48543c8a539df76adb49d972021-11-17T08:30:10ZMorphologic characteristics of nevi associated with melanoma: a clinical, dermatoscopic and histopathologic analysis2160-9381https://doaj.org/article/da9714dee48543c8a539df76adb49d972018-04-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/459https://doaj.org/toc/2160-9381 Background: The aim of this retrospective study was to determine the frequency of nevus-associated melanomas and to better characterize the preexisting nevus from a histopathologic, clinical and dermatoscopic point of view. Methods: We reviewed the histopathologic slides of a consecutive series of 357 melanomas and corresponding clinical and dermatoscopic images, if available. Results: We found that 31 (8.7%) melanomas were associated with a preexisting nevus, 284 (79.5%) melanomas developed de novo, and in 42 (11.8%) a preexisting nevus could not be excluded, although the alternative explanation that the entire lesion represented a melanoma was also possible. The preexisting nevus was a “superficial” or “superficial and deep” congenital nevus in 27 cases (87%) and a Clark nevus in 4 cases (13%). Clinical or dermatoscopic images were available in 149 (41.7%) cases. The preexisting nevus, if visible, looked inconspicuous clinically or dermatoscopically. The median invasion thickness of nevus-associated melanoma was not significantly different from “de novo” melanomas but the frequency of in situ melanomas was higher in the “de novo“ group (40.1% versus 16.1%). Patients with melanoma in association with a nevus were significantly younger (mean age=55 years, SD: 16 years) than patients with “de novo” melanomas (mean age=68 years SD: 15 years, p<0.001). When controlled for age and invasion thickness overall, survival did not differ significantly between patients with nevus-associated melanomas and patients with de novo melanomas. Conclusions: From a histomorphologic point of view, the majority of melanomas arise de novo. If melanomas develop in a preexisting nevus, they usually occur in association with a “superficial” or “superficial and deep” congenital nevus. Temeida AlendarHarald KittlerMattioli1885articlenevusmelanomadermatopathologydermatoscopyDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 8, Iss 1 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	nevus melanoma dermatopathology dermatoscopy Dermatology RL1-803
spellingShingle	nevus melanoma dermatopathology dermatoscopy Dermatology RL1-803 Temeida Alendar Harald Kittler Morphologic characteristics of nevi associated with melanoma: a clinical, dermatoscopic and histopathologic analysis
description	Background: The aim of this retrospective study was to determine the frequency of nevus-associated melanomas and to better characterize the preexisting nevus from a histopathologic, clinical and dermatoscopic point of view. Methods: We reviewed the histopathologic slides of a consecutive series of 357 melanomas and corresponding clinical and dermatoscopic images, if available. Results: We found that 31 (8.7%) melanomas were associated with a preexisting nevus, 284 (79.5%) melanomas developed de novo, and in 42 (11.8%) a preexisting nevus could not be excluded, although the alternative explanation that the entire lesion represented a melanoma was also possible. The preexisting nevus was a “superficial” or “superficial and deep” congenital nevus in 27 cases (87%) and a Clark nevus in 4 cases (13%). Clinical or dermatoscopic images were available in 149 (41.7%) cases. The preexisting nevus, if visible, looked inconspicuous clinically or dermatoscopically. The median invasion thickness of nevus-associated melanoma was not significantly different from “de novo” melanomas but the frequency of in situ melanomas was higher in the “de novo“ group (40.1% versus 16.1%). Patients with melanoma in association with a nevus were significantly younger (mean age=55 years, SD: 16 years) than patients with “de novo” melanomas (mean age=68 years SD: 15 years, p<0.001). When controlled for age and invasion thickness overall, survival did not differ significantly between patients with nevus-associated melanomas and patients with de novo melanomas. Conclusions: From a histomorphologic point of view, the majority of melanomas arise de novo. If melanomas develop in a preexisting nevus, they usually occur in association with a “superficial” or “superficial and deep” congenital nevus.
format	article
author	Temeida Alendar Harald Kittler
author_facet	Temeida Alendar Harald Kittler
author_sort	Temeida Alendar
title	Morphologic characteristics of nevi associated with melanoma: a clinical, dermatoscopic and histopathologic analysis
title_short	Morphologic characteristics of nevi associated with melanoma: a clinical, dermatoscopic and histopathologic analysis
title_full	Morphologic characteristics of nevi associated with melanoma: a clinical, dermatoscopic and histopathologic analysis
title_fullStr	Morphologic characteristics of nevi associated with melanoma: a clinical, dermatoscopic and histopathologic analysis
title_full_unstemmed	Morphologic characteristics of nevi associated with melanoma: a clinical, dermatoscopic and histopathologic analysis
title_sort	morphologic characteristics of nevi associated with melanoma: a clinical, dermatoscopic and histopathologic analysis
publisher	Mattioli1885
publishDate	2018
url	https://doaj.org/article/da9714dee48543c8a539df76adb49d97
work_keys_str_mv	AT temeidaalendar morphologiccharacteristicsofneviassociatedwithmelanomaaclinicaldermatoscopicandhistopathologicanalysis AT haraldkittler morphologiccharacteristicsofneviassociatedwithmelanomaaclinicaldermatoscopicandhistopathologicanalysis
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Morphologic characteristics of nevi associated with melanoma: a clinical, dermatoscopic and histopathologic analysis

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