CFTR trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates

Cystic fibrosis (CF) is a lethal genetic disease that is primarily caused by misfolding of the cystic fibrosis transmembrane conductance regulator (CFTR). Here authors show that disease-causing mutations located within the first nucleotide binding domain of CFTR have distinct effects on nascent poly...

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Autores principales:	Hideki Shishido, Jae Seok Yoon, Zhongying Yang, William R. Skach
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/da97e209777a41fe8119566b8058db29
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spelling	oai:doaj.org-article:da97e209777a41fe8119566b8058db292021-12-02T19:02:36ZCFTR trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates10.1038/s41467-020-18101-82041-1723https://doaj.org/article/da97e209777a41fe8119566b8058db292020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18101-8https://doaj.org/toc/2041-1723Cystic fibrosis (CF) is a lethal genetic disease that is primarily caused by misfolding of the cystic fibrosis transmembrane conductance regulator (CFTR). Here authors show that disease-causing mutations located within the first nucleotide binding domain of CFTR have distinct effects on nascent polypeptides.Hideki ShishidoJae Seok YoonZhongying YangWilliam R. SkachNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hideki Shishido Jae Seok Yoon Zhongying Yang William R. Skach CFTR trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates
description	Cystic fibrosis (CF) is a lethal genetic disease that is primarily caused by misfolding of the cystic fibrosis transmembrane conductance regulator (CFTR). Here authors show that disease-causing mutations located within the first nucleotide binding domain of CFTR have distinct effects on nascent polypeptides.
format	article
author	Hideki Shishido Jae Seok Yoon Zhongying Yang William R. Skach
author_facet	Hideki Shishido Jae Seok Yoon Zhongying Yang William R. Skach
author_sort	Hideki Shishido
title	CFTR trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates
title_short	CFTR trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates
title_full	CFTR trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates
title_fullStr	CFTR trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates
title_full_unstemmed	CFTR trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates
title_sort	cftr trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/da97e209777a41fe8119566b8058db29
work_keys_str_mv	AT hidekishishido cftrtraffickingmutationsdisruptcotranslationalproteinfoldingbytargetingbiosyntheticintermediates AT jaeseokyoon cftrtraffickingmutationsdisruptcotranslationalproteinfoldingbytargetingbiosyntheticintermediates AT zhongyingyang cftrtraffickingmutationsdisruptcotranslationalproteinfoldingbytargetingbiosyntheticintermediates AT williamrskach cftrtraffickingmutationsdisruptcotranslationalproteinfoldingbytargetingbiosyntheticintermediates
_version_	1718377240328142848

CFTR trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates

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