Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK.

Phenotypic plasticity in vascular smooth muscle cells (VSMC) is necessary for vessel maintenance, repair and adaptation to vascular changes associated with aging. De-differentiated VSMC contribute to pathologies including atherosclerosis and intimal hyperplasia. As resveratrol has been reported to h...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Anne Marie Thompson, Kathleen A Martin, Eva M Rzucidlo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/da98a3b60c7a4a28a66acb08033c0dbf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:da98a3b60c7a4a28a66acb08033c0dbf
record_format	dspace
spelling	oai:doaj.org-article:da98a3b60c7a4a28a66acb08033c0dbf2021-11-18T08:38:22ZResveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK.1932-620310.1371/journal.pone.0085495https://doaj.org/article/da98a3b60c7a4a28a66acb08033c0dbf2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24416418/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Phenotypic plasticity in vascular smooth muscle cells (VSMC) is necessary for vessel maintenance, repair and adaptation to vascular changes associated with aging. De-differentiated VSMC contribute to pathologies including atherosclerosis and intimal hyperplasia. As resveratrol has been reported to have cardio- protective effects, we investigated its role in VSMC phenotypic modulation. We demonstrated the novel finding that resveratrol promoted VSMC differentiation as measured by contractile protein expression, contractile morphology and contraction in collagen gels. Resveratrol induced VSMC differentiation through stimulation of SirT1 and AMPK. We made the novel finding that low or high dose resveratrol had an initially different mechanism on induction of differentiation. We found that low dose resveratrol stimulated differentiation through SirT1-mediated activation of AKT, whereas high dose resveratrol stimulated differentiation through AMPK-mediated inhibition of the mTORC1 pathway, allowing activation of AKT. The health effects of resveratrol in cardiovascular diseases, cancer and longevity are an area of active research. We have demonstrated a supplemental avenue where-by resveratrol may promote health by maintaining and enhancing plasticity of the vasculature.Anne Marie ThompsonKathleen A MartinEva M RzucidloPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e85495 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anne Marie Thompson Kathleen A Martin Eva M Rzucidlo Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK.
description	Phenotypic plasticity in vascular smooth muscle cells (VSMC) is necessary for vessel maintenance, repair and adaptation to vascular changes associated with aging. De-differentiated VSMC contribute to pathologies including atherosclerosis and intimal hyperplasia. As resveratrol has been reported to have cardio- protective effects, we investigated its role in VSMC phenotypic modulation. We demonstrated the novel finding that resveratrol promoted VSMC differentiation as measured by contractile protein expression, contractile morphology and contraction in collagen gels. Resveratrol induced VSMC differentiation through stimulation of SirT1 and AMPK. We made the novel finding that low or high dose resveratrol had an initially different mechanism on induction of differentiation. We found that low dose resveratrol stimulated differentiation through SirT1-mediated activation of AKT, whereas high dose resveratrol stimulated differentiation through AMPK-mediated inhibition of the mTORC1 pathway, allowing activation of AKT. The health effects of resveratrol in cardiovascular diseases, cancer and longevity are an area of active research. We have demonstrated a supplemental avenue where-by resveratrol may promote health by maintaining and enhancing plasticity of the vasculature.
format	article
author	Anne Marie Thompson Kathleen A Martin Eva M Rzucidlo
author_facet	Anne Marie Thompson Kathleen A Martin Eva M Rzucidlo
author_sort	Anne Marie Thompson
title	Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK.
title_short	Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK.
title_full	Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK.
title_fullStr	Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK.
title_full_unstemmed	Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK.
title_sort	resveratrol induces vascular smooth muscle cell differentiation through stimulation of sirt1 and ampk.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/da98a3b60c7a4a28a66acb08033c0dbf
work_keys_str_mv	AT annemariethompson resveratrolinducesvascularsmoothmusclecelldifferentiationthroughstimulationofsirt1andampk AT kathleenamartin resveratrolinducesvascularsmoothmusclecelldifferentiationthroughstimulationofsirt1andampk AT evamrzucidlo resveratrolinducesvascularsmoothmusclecelldifferentiationthroughstimulationofsirt1andampk
_version_	1718421530866614272

Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK.

Ejemplares similares