Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK.
Phenotypic plasticity in vascular smooth muscle cells (VSMC) is necessary for vessel maintenance, repair and adaptation to vascular changes associated with aging. De-differentiated VSMC contribute to pathologies including atherosclerosis and intimal hyperplasia. As resveratrol has been reported to h...
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Autores principales: | Anne Marie Thompson, Kathleen A Martin, Eva M Rzucidlo |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2014
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Materias: | |
Acceso en línea: | https://doaj.org/article/da98a3b60c7a4a28a66acb08033c0dbf |
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