$Bisphosphonate use and hip fracture epidemiology: ecologic proof from the contrary$
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Bisphosphonate use and hip fracture epidemiology: ecologic proof from the contrary

Alex Fisher1, Jodie Martin2, Wichat Srikusalanukul2, Michael Davis11Department of Geriatric Medicine, The Canberra Hospital, Canberra, ACT, Australia; 2Australian National University Medical School, Canberra, ACT, AustraliaAim: The objective of this article is to evaluate the relationship between th...

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Autores principales:	Alex Fisher, Jodie Martin, Wichat Srikusalanukul, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Bisphosphonate use hip fracture epidemiology Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/da9decfd353345a48fe1bda4fc9cd7d8
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spelling	oai:doaj.org-article:da9decfd353345a48fe1bda4fc9cd7d82021-12-02T08:37:08ZBisphosphonate use and hip fracture epidemiology: ecologic proof from the contrary1178-1998https://doaj.org/article/da9decfd353345a48fe1bda4fc9cd7d82010-11-01T00:00:00Zhttps://www.dovepress.com/bisphosphonate-use-and-hip-fracture-epidemiology-ecologic-proof-from-t-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Alex Fisher1, Jodie Martin2, Wichat Srikusalanukul2, Michael Davis11Department of Geriatric Medicine, The Canberra Hospital, Canberra, ACT, Australia; 2Australian National University Medical School, Canberra, ACT, AustraliaAim: The objective of this article is to evaluate the relationship between the changes in prescriptions of antiosteoporotic drugs (mainly the rapid fall in the use of bisphosphonates [BPs]) and standardized hip fracture (HF) rates over the period 2005–2008 in the Australian Capital Territory (ACT).Methods: Annual sex- and age-specific HF rates (per 100,000 population) were determined and standardized using the Australian 2006 population census. Data on the annual prescriptions of BPs (mainly alendronate and risedronate), strontium ranelate, and hormone replacement therapy were obtained from the Australian Pharmaceutical Benefits Scheme (PBS) and Repatriation Australian Pharmaceutical Benefits Scheme (RPBS) databases.Results: In the ACT, the peak annual number of prescriptions for BPs was observed in 2006. Following reports linking osteonecrosis of the jaw with BP use, the number of BP prescriptions dropped by 14% in 2007–2008 compared with 2005, when the lowest HF rates were recorded. The reduction in BP prescriptions coincided with increased HF rates in females in 2007 (+22.6%) and in 2008 (+25.2%) compared with 2005; in males, HF incidence declined by 6.6% and 16.7%, respectively. The proportion of filled prescriptions for strontium ranelate, risedronate, and alendronate in 2007–2008 was 1:8.4:15.5, indicating that BPs were the dominant antiosteoporotic drugs. There was an inverse statistically significant relationship between the total annual number of BP prescriptions and standardized HF incidence rates for the 10-year period 1999–2008.Conclusion: Although currently there is no clear understanding of factors contributing to changing HF epidemiology, the available evidence suggests that much of the decline in HF rates is due to the use of BPs. The fall in the use of BPs is associated with an increase in HF rates in females, indicating that BPs should still be considered the first-line medications for the prevention and treatment of osteoporosis. Our results need to be confirmed in other populations and countries.Keywords: bisphosphonate use, hip fracture, epidemiologyAlex FisherJodie MartinWichat Srikusalanukulet alDove Medical PressarticleBisphosphonate usehip fractureepidemiologyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 5, Pp 355-362 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bisphosphonate use hip fracture epidemiology Geriatrics RC952-954.6
spellingShingle	Bisphosphonate use hip fracture epidemiology Geriatrics RC952-954.6 Alex Fisher Jodie Martin Wichat Srikusalanukul et al Bisphosphonate use and hip fracture epidemiology: ecologic proof from the contrary
description	Alex Fisher1, Jodie Martin2, Wichat Srikusalanukul2, Michael Davis11Department of Geriatric Medicine, The Canberra Hospital, Canberra, ACT, Australia; 2Australian National University Medical School, Canberra, ACT, AustraliaAim: The objective of this article is to evaluate the relationship between the changes in prescriptions of antiosteoporotic drugs (mainly the rapid fall in the use of bisphosphonates [BPs]) and standardized hip fracture (HF) rates over the period 2005–2008 in the Australian Capital Territory (ACT).Methods: Annual sex- and age-specific HF rates (per 100,000 population) were determined and standardized using the Australian 2006 population census. Data on the annual prescriptions of BPs (mainly alendronate and risedronate), strontium ranelate, and hormone replacement therapy were obtained from the Australian Pharmaceutical Benefits Scheme (PBS) and Repatriation Australian Pharmaceutical Benefits Scheme (RPBS) databases.Results: In the ACT, the peak annual number of prescriptions for BPs was observed in 2006. Following reports linking osteonecrosis of the jaw with BP use, the number of BP prescriptions dropped by 14% in 2007–2008 compared with 2005, when the lowest HF rates were recorded. The reduction in BP prescriptions coincided with increased HF rates in females in 2007 (+22.6%) and in 2008 (+25.2%) compared with 2005; in males, HF incidence declined by 6.6% and 16.7%, respectively. The proportion of filled prescriptions for strontium ranelate, risedronate, and alendronate in 2007–2008 was 1:8.4:15.5, indicating that BPs were the dominant antiosteoporotic drugs. There was an inverse statistically significant relationship between the total annual number of BP prescriptions and standardized HF incidence rates for the 10-year period 1999–2008.Conclusion: Although currently there is no clear understanding of factors contributing to changing HF epidemiology, the available evidence suggests that much of the decline in HF rates is due to the use of BPs. The fall in the use of BPs is associated with an increase in HF rates in females, indicating that BPs should still be considered the first-line medications for the prevention and treatment of osteoporosis. Our results need to be confirmed in other populations and countries.Keywords: bisphosphonate use, hip fracture, epidemiology
format	article
author	Alex Fisher Jodie Martin Wichat Srikusalanukul et al
author_facet	Alex Fisher Jodie Martin Wichat Srikusalanukul et al
author_sort	Alex Fisher
title	Bisphosphonate use and hip fracture epidemiology: ecologic proof from the contrary
title_short	Bisphosphonate use and hip fracture epidemiology: ecologic proof from the contrary
title_full	Bisphosphonate use and hip fracture epidemiology: ecologic proof from the contrary
title_fullStr	Bisphosphonate use and hip fracture epidemiology: ecologic proof from the contrary
title_full_unstemmed	Bisphosphonate use and hip fracture epidemiology: ecologic proof from the contrary
title_sort	bisphosphonate use and hip fracture epidemiology: ecologic proof from the contrary
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/da9decfd353345a48fe1bda4fc9cd7d8
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Bisphosphonate use and hip fracture epidemiology: ecologic proof from the contrary

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