Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex

Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex

Lipid antigens have been added to the antigenic repertoire in recent years. Here, the authors have identified Mamu-B*098 as a lipopeptide antigen presenting molecule and using structural and biochemical analysis have shown that it has a different antigen binding pocket to previously analysed protein...

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Bibliographic Details
Main Authors: Daisuke Morita, Yukie Yamamoto, Tatsuaki Mizutani, Takeshi Ishikawa, Juri Suzuki, Tatsuhiko Igarashi, Naoki Mori, Takashi Shiina, Hidetoshi Inoko, Hiroaki Fujita, Kazuhiro Iwai, Yoshimasa Tanaka, Bunzo Mikami, Masahiko Sugita
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
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Online Access:https://doaj.org/article/daa53f15e3cb4a25a747098318e53ec1
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Summary:Lipid antigens have been added to the antigenic repertoire in recent years. Here, the authors have identified Mamu-B*098 as a lipopeptide antigen presenting molecule and using structural and biochemical analysis have shown that it has a different antigen binding pocket to previously analysed proteins.

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