Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Around 10% of high-grade serous ovarian carcinomas (HGSOC) harbor BRCA1 promoter methylation, but it is uncertain how it predicts response to PARP inhibition. Here, the authors show that homozygous BRCA1 methylation predicts response to rucaparib while heterozygous methylation of BRCA1 predicts resi...

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Autores principales: Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo-Yaw Ho, Maria I. Harrell, Giada V. Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B. Pearson, John J. Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J. Hutt, Scott H. Kaufmann, Kevin K. Lin, Thomas C. Harding, Nadia Traficante, Australian Ovarian Cancer Study (AOCS), Anna deFazio, Iain A. McNeish, David D. Bowtell, Elizabeth M. Swisher, Alexander Dobrovic, Matthew J. Wakefield, Clare L. Scott
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/daa72fc740814394b7993401524f3f72
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spelling oai:doaj.org-article:daa72fc740814394b7993401524f3f722021-12-02T17:32:18ZMethylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma10.1038/s41467-018-05564-z2041-1723https://doaj.org/article/daa72fc740814394b7993401524f3f722018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05564-zhttps://doaj.org/toc/2041-1723Around 10% of high-grade serous ovarian carcinomas (HGSOC) harbor BRCA1 promoter methylation, but it is uncertain how it predicts response to PARP inhibition. Here, the authors show that homozygous BRCA1 methylation predicts response to rucaparib while heterozygous methylation of BRCA1 predicts resistance in HGSOC.Olga KondrashovaMonique ToppKsenija NesicElizabeth LieschkeGwo-Yaw HoMaria I. HarrellGiada V. ZapparoliAlison HadleyRobert HolianEmma BoehmValerie HeongElaine SanijRichard B. PearsonJohn J. KraisNeil JohnsonOrla McNallySumitra AnandaKathryn AlsopKarla J. HuttScott H. KaufmannKevin K. LinThomas C. HardingNadia TraficanteAustralian Ovarian Cancer Study (AOCS)Anna deFazioIain A. McNeishDavid D. BowtellElizabeth M. SwisherAlexander DobrovicMatthew J. WakefieldClare L. ScottNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Olga Kondrashova
Monique Topp
Ksenija Nesic
Elizabeth Lieschke
Gwo-Yaw Ho
Maria I. Harrell
Giada V. Zapparoli
Alison Hadley
Robert Holian
Emma Boehm
Valerie Heong
Elaine Sanij
Richard B. Pearson
John J. Krais
Neil Johnson
Orla McNally
Sumitra Ananda
Kathryn Alsop
Karla J. Hutt
Scott H. Kaufmann
Kevin K. Lin
Thomas C. Harding
Nadia Traficante
Australian Ovarian Cancer Study (AOCS)
Anna deFazio
Iain A. McNeish
David D. Bowtell
Elizabeth M. Swisher
Alexander Dobrovic
Matthew J. Wakefield
Clare L. Scott
Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma
description Around 10% of high-grade serous ovarian carcinomas (HGSOC) harbor BRCA1 promoter methylation, but it is uncertain how it predicts response to PARP inhibition. Here, the authors show that homozygous BRCA1 methylation predicts response to rucaparib while heterozygous methylation of BRCA1 predicts resistance in HGSOC.
format article
author Olga Kondrashova
Monique Topp
Ksenija Nesic
Elizabeth Lieschke
Gwo-Yaw Ho
Maria I. Harrell
Giada V. Zapparoli
Alison Hadley
Robert Holian
Emma Boehm
Valerie Heong
Elaine Sanij
Richard B. Pearson
John J. Krais
Neil Johnson
Orla McNally
Sumitra Ananda
Kathryn Alsop
Karla J. Hutt
Scott H. Kaufmann
Kevin K. Lin
Thomas C. Harding
Nadia Traficante
Australian Ovarian Cancer Study (AOCS)
Anna deFazio
Iain A. McNeish
David D. Bowtell
Elizabeth M. Swisher
Alexander Dobrovic
Matthew J. Wakefield
Clare L. Scott
author_facet Olga Kondrashova
Monique Topp
Ksenija Nesic
Elizabeth Lieschke
Gwo-Yaw Ho
Maria I. Harrell
Giada V. Zapparoli
Alison Hadley
Robert Holian
Emma Boehm
Valerie Heong
Elaine Sanij
Richard B. Pearson
John J. Krais
Neil Johnson
Orla McNally
Sumitra Ananda
Kathryn Alsop
Karla J. Hutt
Scott H. Kaufmann
Kevin K. Lin
Thomas C. Harding
Nadia Traficante
Australian Ovarian Cancer Study (AOCS)
Anna deFazio
Iain A. McNeish
David D. Bowtell
Elizabeth M. Swisher
Alexander Dobrovic
Matthew J. Wakefield
Clare L. Scott
author_sort Olga Kondrashova
title Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma
title_short Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma
title_full Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma
title_fullStr Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma
title_full_unstemmed Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma
title_sort methylation of all brca1 copies predicts response to the parp inhibitor rucaparib in ovarian carcinoma
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/daa72fc740814394b7993401524f3f72
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