New insights in the expression of stromal caveolin 1 in breast cancer spread to axillary lymph nodes

Abstract Recent evidence suggests that a loss of expression of caveolin in the stromal compartment (sCav-1) of human invasive breast carcinoma (IBC) may be a predictor of disease recurrence, metastasis and poor outcome. At present, there is little knowledge regarding the expression of sCav-1 at the...

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Autores principales:	Cristian Scatena, Giovanni Fanelli, Giuseppe Nicolò Fanelli, Michele Menicagli, Paolo Aretini, Valerio Ortenzi, Sara Piera Civitelli, Lorenzo Innocenti, Federica Sotgia, Michael P. Lisanti, Antonio Giuseppe Naccarato
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/daa8355ce42840c988783df105fba6a4
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spelling	oai:doaj.org-article:daa8355ce42840c988783df105fba6a42021-12-02T14:06:31ZNew insights in the expression of stromal caveolin 1 in breast cancer spread to axillary lymph nodes10.1038/s41598-021-82405-y2045-2322https://doaj.org/article/daa8355ce42840c988783df105fba6a42021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82405-yhttps://doaj.org/toc/2045-2322Abstract Recent evidence suggests that a loss of expression of caveolin in the stromal compartment (sCav-1) of human invasive breast carcinoma (IBC) may be a predictor of disease recurrence, metastasis and poor outcome. At present, there is little knowledge regarding the expression of sCav-1 at the metastatic sites. We therefore studied sCav-1 expression in IBCs and in their axillary lymph nodes to seek a correlation with cancer metastasis. 189 consecutive invasive IBCs (53 with axillary lymph node metastases and 136 without) were studied by immunohistochemistry, using a rabbit polyclonal anti-Cav-1 antibody. In IBCs sCav-1 was evaluated in fibroblasts scattered in the tumor stroma whereas in lymph nodes sCav-1 was assessed in fibroblast-like stromal cells. For the first time, we observed a statistically significant progressive loss of sCav-1 from normal/reactive axillary lymph nodes of tumors limited to the breast to metastatic axillary lymph nodes, through normal/reactive axillary lymph nodes of tumors with axillary metastatic spread. These data indicate that Cav-1 expressed by the stromal compartment of lymph nodes, somehow, may possibly contribute to metastatic spread in IBC.Cristian ScatenaGiovanni FanelliGiuseppe Nicolò FanelliMichele MenicagliPaolo AretiniValerio OrtenziSara Piera CivitelliLorenzo InnocentiFederica SotgiaMichael P. LisantiAntonio Giuseppe NaccaratoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cristian Scatena Giovanni Fanelli Giuseppe Nicolò Fanelli Michele Menicagli Paolo Aretini Valerio Ortenzi Sara Piera Civitelli Lorenzo Innocenti Federica Sotgia Michael P. Lisanti Antonio Giuseppe Naccarato New insights in the expression of stromal caveolin 1 in breast cancer spread to axillary lymph nodes
description	Abstract Recent evidence suggests that a loss of expression of caveolin in the stromal compartment (sCav-1) of human invasive breast carcinoma (IBC) may be a predictor of disease recurrence, metastasis and poor outcome. At present, there is little knowledge regarding the expression of sCav-1 at the metastatic sites. We therefore studied sCav-1 expression in IBCs and in their axillary lymph nodes to seek a correlation with cancer metastasis. 189 consecutive invasive IBCs (53 with axillary lymph node metastases and 136 without) were studied by immunohistochemistry, using a rabbit polyclonal anti-Cav-1 antibody. In IBCs sCav-1 was evaluated in fibroblasts scattered in the tumor stroma whereas in lymph nodes sCav-1 was assessed in fibroblast-like stromal cells. For the first time, we observed a statistically significant progressive loss of sCav-1 from normal/reactive axillary lymph nodes of tumors limited to the breast to metastatic axillary lymph nodes, through normal/reactive axillary lymph nodes of tumors with axillary metastatic spread. These data indicate that Cav-1 expressed by the stromal compartment of lymph nodes, somehow, may possibly contribute to metastatic spread in IBC.
format	article
author	Cristian Scatena Giovanni Fanelli Giuseppe Nicolò Fanelli Michele Menicagli Paolo Aretini Valerio Ortenzi Sara Piera Civitelli Lorenzo Innocenti Federica Sotgia Michael P. Lisanti Antonio Giuseppe Naccarato
author_facet	Cristian Scatena Giovanni Fanelli Giuseppe Nicolò Fanelli Michele Menicagli Paolo Aretini Valerio Ortenzi Sara Piera Civitelli Lorenzo Innocenti Federica Sotgia Michael P. Lisanti Antonio Giuseppe Naccarato
author_sort	Cristian Scatena
title	New insights in the expression of stromal caveolin 1 in breast cancer spread to axillary lymph nodes
title_short	New insights in the expression of stromal caveolin 1 in breast cancer spread to axillary lymph nodes
title_full	New insights in the expression of stromal caveolin 1 in breast cancer spread to axillary lymph nodes
title_fullStr	New insights in the expression of stromal caveolin 1 in breast cancer spread to axillary lymph nodes
title_full_unstemmed	New insights in the expression of stromal caveolin 1 in breast cancer spread to axillary lymph nodes
title_sort	new insights in the expression of stromal caveolin 1 in breast cancer spread to axillary lymph nodes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/daa8355ce42840c988783df105fba6a4
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New insights in the expression of stromal caveolin 1 in breast cancer spread to axillary lymph nodes

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