Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease
Bruno Fonseca-Santos, Maria Palmira Daflon Gremião, Marlus ChorilliDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, BrazilAbstract: Alzheimer’s disease is a neurological disorde...
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Dove Medical Press
2015
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oai:doaj.org-article:daad045ca03a4fada451c03ac3b94af32021-12-02T05:40:37ZNanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease1178-2013https://doaj.org/article/daad045ca03a4fada451c03ac3b94af32015-08-01T00:00:00Zhttp://www.dovepress.com/nanotechnology-based-drug-delivery-systems-for-the-treatment-of-alzhei-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Bruno Fonseca-Santos, Maria Palmira Daflon Gremião, Marlus ChorilliDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, BrazilAbstract: Alzheimer’s disease is a neurological disorder that results in cognitive and behavioral impairment. Conventional treatment strategies, such as acetylcholinesterase inhibitor drugs, often fail due to their poor solubility, lower bioavailability, and ineffective ability to cross the blood–brain barrier. Nanotechnological treatment methods, which involve the design, characterization, production, and application of nanoscale drug delivery systems, have been employed to optimize therapeutics. These nanotechnologies include polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, microemulsion, nanoemulsion, and liquid crystals. Each of these are promising tools for the delivery of therapeutic devices to the brain via various routes of administration, particularly the intranasal route. The objective of this study is to present a systematic review of nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease.Keywords: Alzheimer’s disease, polymeric nanoparticles, solid lipid nanocarriers, microemulsions, liquid crystals, targeted delivery, nose-to-brainFonseca-Santos BGremião MPChorilli MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 4981-5003 (2015) |
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DOAJ |
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DOAJ |
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EN |
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Medicine (General) R5-920 |
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Medicine (General) R5-920 Fonseca-Santos B Gremião MP Chorilli M Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease |
| description |
Bruno Fonseca-Santos, Maria Palmira Daflon Gremião, Marlus ChorilliDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, BrazilAbstract: Alzheimer’s disease is a neurological disorder that results in cognitive and behavioral impairment. Conventional treatment strategies, such as acetylcholinesterase inhibitor drugs, often fail due to their poor solubility, lower bioavailability, and ineffective ability to cross the blood–brain barrier. Nanotechnological treatment methods, which involve the design, characterization, production, and application of nanoscale drug delivery systems, have been employed to optimize therapeutics. These nanotechnologies include polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, microemulsion, nanoemulsion, and liquid crystals. Each of these are promising tools for the delivery of therapeutic devices to the brain via various routes of administration, particularly the intranasal route. The objective of this study is to present a systematic review of nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease.Keywords: Alzheimer’s disease, polymeric nanoparticles, solid lipid nanocarriers, microemulsions, liquid crystals, targeted delivery, nose-to-brain |
| format |
article |
| author |
Fonseca-Santos B Gremião MP Chorilli M |
| author_facet |
Fonseca-Santos B Gremião MP Chorilli M |
| author_sort |
Fonseca-Santos B |
| title |
Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease |
| title_short |
Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease |
| title_full |
Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease |
| title_fullStr |
Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease |
| title_full_unstemmed |
Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease |
| title_sort |
nanotechnology-based drug delivery systems for the treatment of alzheimer’s disease |
| publisher |
Dove Medical Press |
| publishDate |
2015 |
| url |
https://doaj.org/article/daad045ca03a4fada451c03ac3b94af3 |
| work_keys_str_mv |
AT fonsecasantosb nanotechnologybaseddrugdeliverysystemsforthetreatmentofalzheimerrsquosdisease AT gremiatildeomp nanotechnologybaseddrugdeliverysystemsforthetreatmentofalzheimerrsquosdisease AT chorillim nanotechnologybaseddrugdeliverysystemsforthetreatmentofalzheimerrsquosdisease |
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1718400324680548352 |