Identifying molecular pathways and candidate genes associated with knob traits by transcriptome analysis in the goose (Anser cygnoides)

Abstract Anser cygnoides has a spherical crest on the beak roof, which is described as knob. However, the mechanisms affecting knob morphology are unclear. Here, we investigated the phenotypic characteristics and molecular basis of knob-size differences in Yangzhou geese. Anatomically, the knob was...

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Autores principales:	Wangyang Ji, li E Hou, Xiaoya Yuan, Tiantian Gu, ZhuoYu Chen, Yu Zhang, Yang Zhang, Guohong Chen, Qi Xu, Wenming Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/daad06f5794c4c28a876bcd323cf7c1e
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spelling	oai:doaj.org-article:daad06f5794c4c28a876bcd323cf7c1e2021-12-02T17:52:42ZIdentifying molecular pathways and candidate genes associated with knob traits by transcriptome analysis in the goose (Anser cygnoides)10.1038/s41598-021-91269-12045-2322https://doaj.org/article/daad06f5794c4c28a876bcd323cf7c1e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91269-1https://doaj.org/toc/2045-2322Abstract Anser cygnoides has a spherical crest on the beak roof, which is described as knob. However, the mechanisms affecting knob morphology are unclear. Here, we investigated the phenotypic characteristics and molecular basis of knob-size differences in Yangzhou geese. Anatomically, the knob was identified as frontal hump in the frontal area of the skull, rather than hump of upper beak. Although the frontal hump length, and height varied greatly in geese with different knob phenotypes, little was changed in the width. Histologically, knob skin in large-size knobs geese have a greater length in the stratum corneum, stratum spinosum, and stratum reticular than that in small-size knobs geese. Moveover, the 415 differentially expressed genes were found between the large knobs and small ones through transcriptome profiling. In addition, GO enrichment and KEGG pathway analysis revealed 455 significant GO terms and 210 KEGG pathways were enriched, respectively. Among these, TGF-β signaling and thyroid hormone synthesis-signaling pathways were identified to determine knob-size phenotype. Furthermore, BMP5, DCN, TSHR and ADCY3 were recognized to involve in the growth and development of knob. Our data provide comprehensive molecular determinants of knob size phenotype, which can potentially promote the genetic improvement of goose knobs.Wangyang Jili E HouXiaoya YuanTiantian GuZhuoYu ChenYu ZhangYang ZhangGuohong ChenQi XuWenming ZhaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wangyang Ji li E Hou Xiaoya Yuan Tiantian Gu ZhuoYu Chen Yu Zhang Yang Zhang Guohong Chen Qi Xu Wenming Zhao Identifying molecular pathways and candidate genes associated with knob traits by transcriptome analysis in the goose (Anser cygnoides)
description	Abstract Anser cygnoides has a spherical crest on the beak roof, which is described as knob. However, the mechanisms affecting knob morphology are unclear. Here, we investigated the phenotypic characteristics and molecular basis of knob-size differences in Yangzhou geese. Anatomically, the knob was identified as frontal hump in the frontal area of the skull, rather than hump of upper beak. Although the frontal hump length, and height varied greatly in geese with different knob phenotypes, little was changed in the width. Histologically, knob skin in large-size knobs geese have a greater length in the stratum corneum, stratum spinosum, and stratum reticular than that in small-size knobs geese. Moveover, the 415 differentially expressed genes were found between the large knobs and small ones through transcriptome profiling. In addition, GO enrichment and KEGG pathway analysis revealed 455 significant GO terms and 210 KEGG pathways were enriched, respectively. Among these, TGF-β signaling and thyroid hormone synthesis-signaling pathways were identified to determine knob-size phenotype. Furthermore, BMP5, DCN, TSHR and ADCY3 were recognized to involve in the growth and development of knob. Our data provide comprehensive molecular determinants of knob size phenotype, which can potentially promote the genetic improvement of goose knobs.
format	article
author	Wangyang Ji li E Hou Xiaoya Yuan Tiantian Gu ZhuoYu Chen Yu Zhang Yang Zhang Guohong Chen Qi Xu Wenming Zhao
author_facet	Wangyang Ji li E Hou Xiaoya Yuan Tiantian Gu ZhuoYu Chen Yu Zhang Yang Zhang Guohong Chen Qi Xu Wenming Zhao
author_sort	Wangyang Ji
title	Identifying molecular pathways and candidate genes associated with knob traits by transcriptome analysis in the goose (Anser cygnoides)
title_short	Identifying molecular pathways and candidate genes associated with knob traits by transcriptome analysis in the goose (Anser cygnoides)
title_full	Identifying molecular pathways and candidate genes associated with knob traits by transcriptome analysis in the goose (Anser cygnoides)
title_fullStr	Identifying molecular pathways and candidate genes associated with knob traits by transcriptome analysis in the goose (Anser cygnoides)
title_full_unstemmed	Identifying molecular pathways and candidate genes associated with knob traits by transcriptome analysis in the goose (Anser cygnoides)
title_sort	identifying molecular pathways and candidate genes associated with knob traits by transcriptome analysis in the goose (anser cygnoides)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/daad06f5794c4c28a876bcd323cf7c1e
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Identifying molecular pathways and candidate genes associated with knob traits by transcriptome analysis in the goose (Anser cygnoides)

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