Changes in Brain Structure, Function, and Network Properties in Patients With First-Episode Schizophrenia Treated With Antipsychotics

Purpose: Comprehensive and longitudinal brain analysis is of great significance for understanding the pathological changes of antipsychotic drug treatment in patients with schizophrenia. This study aimed to investigate the changes of structure, function, and network properties in patients with first...

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Autores principales:	Ping Yin, Chao Zhao, Yang Li, Xiaoyi Liu, Lei Chen, Nan Hong
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	schizophrenia first-episode antipsychotics neuroimaging functional magnetic resonance imaging Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/daae0975f468420da57a6fadca6f1e10
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spelling	oai:doaj.org-article:daae0975f468420da57a6fadca6f1e102021-12-01T15:13:35ZChanges in Brain Structure, Function, and Network Properties in Patients With First-Episode Schizophrenia Treated With Antipsychotics1664-064010.3389/fpsyt.2021.735623https://doaj.org/article/daae0975f468420da57a6fadca6f1e102021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.735623/fullhttps://doaj.org/toc/1664-0640Purpose: Comprehensive and longitudinal brain analysis is of great significance for understanding the pathological changes of antipsychotic drug treatment in patients with schizophrenia. This study aimed to investigate the changes of structure, function, and network properties in patients with first-episode schizophrenia (FES) after antipsychotic therapy and their relationship with clinical symptoms.Materials and Methods: A total of 30 patients diagnosed with FES and 30 healthy subjects matched for sex and age were enrolled in our study. Patients at baseline were labeled as antipsychotic-naive first-episode schizophrenia (AN-FES), and patients after antipsychotic treatment were labeled as antipsychotic treatment first-episode schizophrenia (AT-FES). The severity of illness was measured by using the PANSS and CGI score. Structural and functional MRI data were also performed. Differences in GMV, ALFF, and ReHo between the FES group and healthy control group were tested using a voxel-wise two-sample t-test, and the comparison of AN-FES group and AT-FES group was evaluated by paired-sample t-test.Results: After the 1-year follow-up, the FES patients showed increased GMV in the right cerebellum, right inferior temporal gyrus, left middle frontal gyrus, parahippocampal gyrus, bilateral inferior parietal lobule, and reduced GMV in the left occipital lobe, gyrus rectus, right orbital frontal cortex. The patients also showed increased ALFF in the medial superior frontal gyrus and right precentral gyrus. For network properties, the patients showed reduced characteristic path length and increased global efficiency. The GMV of the right inferior parietal lobule was negatively correlated with the clinical symptoms.Conclusions: Our study showed that the antipsychotic treatment contributed to the structural alteration and functional improvement, and the GMV alteration may be associated with the improvement of clinical symptoms.Ping YinChao ZhaoYang LiXiaoyi LiuLei ChenNan HongFrontiers Media S.A.articleschizophreniafirst-episodeantipsychoticsneuroimagingfunctional magnetic resonance imagingPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	schizophrenia first-episode antipsychotics neuroimaging functional magnetic resonance imaging Psychiatry RC435-571
spellingShingle	schizophrenia first-episode antipsychotics neuroimaging functional magnetic resonance imaging Psychiatry RC435-571 Ping Yin Chao Zhao Yang Li Xiaoyi Liu Lei Chen Nan Hong Changes in Brain Structure, Function, and Network Properties in Patients With First-Episode Schizophrenia Treated With Antipsychotics
description	Purpose: Comprehensive and longitudinal brain analysis is of great significance for understanding the pathological changes of antipsychotic drug treatment in patients with schizophrenia. This study aimed to investigate the changes of structure, function, and network properties in patients with first-episode schizophrenia (FES) after antipsychotic therapy and their relationship with clinical symptoms.Materials and Methods: A total of 30 patients diagnosed with FES and 30 healthy subjects matched for sex and age were enrolled in our study. Patients at baseline were labeled as antipsychotic-naive first-episode schizophrenia (AN-FES), and patients after antipsychotic treatment were labeled as antipsychotic treatment first-episode schizophrenia (AT-FES). The severity of illness was measured by using the PANSS and CGI score. Structural and functional MRI data were also performed. Differences in GMV, ALFF, and ReHo between the FES group and healthy control group were tested using a voxel-wise two-sample t-test, and the comparison of AN-FES group and AT-FES group was evaluated by paired-sample t-test.Results: After the 1-year follow-up, the FES patients showed increased GMV in the right cerebellum, right inferior temporal gyrus, left middle frontal gyrus, parahippocampal gyrus, bilateral inferior parietal lobule, and reduced GMV in the left occipital lobe, gyrus rectus, right orbital frontal cortex. The patients also showed increased ALFF in the medial superior frontal gyrus and right precentral gyrus. For network properties, the patients showed reduced characteristic path length and increased global efficiency. The GMV of the right inferior parietal lobule was negatively correlated with the clinical symptoms.Conclusions: Our study showed that the antipsychotic treatment contributed to the structural alteration and functional improvement, and the GMV alteration may be associated with the improvement of clinical symptoms.
format	article
author	Ping Yin Chao Zhao Yang Li Xiaoyi Liu Lei Chen Nan Hong
author_facet	Ping Yin Chao Zhao Yang Li Xiaoyi Liu Lei Chen Nan Hong
author_sort	Ping Yin
title	Changes in Brain Structure, Function, and Network Properties in Patients With First-Episode Schizophrenia Treated With Antipsychotics
title_short	Changes in Brain Structure, Function, and Network Properties in Patients With First-Episode Schizophrenia Treated With Antipsychotics
title_full	Changes in Brain Structure, Function, and Network Properties in Patients With First-Episode Schizophrenia Treated With Antipsychotics
title_fullStr	Changes in Brain Structure, Function, and Network Properties in Patients With First-Episode Schizophrenia Treated With Antipsychotics
title_full_unstemmed	Changes in Brain Structure, Function, and Network Properties in Patients With First-Episode Schizophrenia Treated With Antipsychotics
title_sort	changes in brain structure, function, and network properties in patients with first-episode schizophrenia treated with antipsychotics
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/daae0975f468420da57a6fadca6f1e10
work_keys_str_mv	AT pingyin changesinbrainstructurefunctionandnetworkpropertiesinpatientswithfirstepisodeschizophreniatreatedwithantipsychotics AT chaozhao changesinbrainstructurefunctionandnetworkpropertiesinpatientswithfirstepisodeschizophreniatreatedwithantipsychotics AT yangli changesinbrainstructurefunctionandnetworkpropertiesinpatientswithfirstepisodeschizophreniatreatedwithantipsychotics AT xiaoyiliu changesinbrainstructurefunctionandnetworkpropertiesinpatientswithfirstepisodeschizophreniatreatedwithantipsychotics AT leichen changesinbrainstructurefunctionandnetworkpropertiesinpatientswithfirstepisodeschizophreniatreatedwithantipsychotics AT nanhong changesinbrainstructurefunctionandnetworkpropertiesinpatientswithfirstepisodeschizophreniatreatedwithantipsychotics
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Changes in Brain Structure, Function, and Network Properties in Patients With First-Episode Schizophrenia Treated With Antipsychotics

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